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Its disruption involves mechanisms such as abnormal \u03b1\u2010synuclein transport, tight junction breakdown, inflammatory activation, and vascular remodeling, all of which significantly disturb the neural microenvironment. Imaging technologies are playing an increasingly pivotal role in unraveling these complex processes. Based on current clinical and experimental evidence, this review outlines the major mechanisms of BBB disruption in PD and focuses on recent advances in multiscale imaging techniques for BBB research. It covers super\u2010resolution microscopy, two\u2010photon imaging, MRI, and PET, emphasizing their critical value in mechanistic investigation, functional assessment, and target localization. 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