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The aim of this study was to evaluate whether 2\u2009weeks of ethanol, combined with intermediate noise exposure, can affect different behaviors, using an animal model. In addition, enriched environment housing was used as a neuroprotective strategy. Adolescent Wistar rats of both sexes were subjected to a 6\u2010session voluntary two\u2010bottle choice ethanol paradigm. A subgroup was exposed to noise for 2\u2009h after Session 3, and some rats were housed in enriched cages. Open field, elevated plus maze, and inhibitory avoidance tasks were used to assess hippocampal\u2010related behaviors. Present results show sex\u2010 and housing\u2010dependent changes in ethanol intake, showing an overall decrease in consumption, with females increasing preference in the last sessions. Exposure to both agents impaired associative memory in both sexes. In contrast, whereas ethanol had anxiolytic effects in females, together with increased novelty\u2010seeking and exploratory behavior, opposite changes were found in males. Noise exposure increased anxiety\u2010like behavior in both sexes, but males and females displayed opposing alterations in other behavioral measures. Combined exposure resulted in effects equal to or less pronounced than those elicited by noise alone. Most behavioral changes were prevented, at least partially, by enriched environment housing. These findings suggest that this animal model may provide insights into the behavioral alterations observed in adolescents exposed to alcohol and noise in leisure settings. Additionally, an enriched environment proved to be a partially effective neuroprotective strategy in both sexes.<\/jats:p>","DOI":"10.1111\/ejn.70279","type":"journal-article","created":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T05:44:56Z","timestamp":1761025496000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of Enriched Environment on Hippocampal\u2010Related Behavioral Changes Induced by Extended Voluntary Ethanol Intake and Noise Exposure in Male and Female Adolescent Wistar Rats"],"prefix":"10.1111","volume":"62","author":[{"given":"G.\u00a0E.","family":"Buj\u00e1n","sequence":"first","affiliation":[{"name":"Facultad de Medicina, Departamento de Toxicolog\u00eda y Farmacolog\u00eda, 1\u00aa C\u00e1tedra de Farmacolog\u00eda Universidad de Buenos Aires  Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"D'Alessio","sequence":"additional","affiliation":[{"name":"Facultad de Medicina, Departamento de Toxicolog\u00eda y Farmacolog\u00eda, 1\u00aa C\u00e1tedra de Farmacolog\u00eda Universidad de Buenos Aires  Buenos Aires Argentina"},{"name":"CONICET\u2014Universidad de Buenos Aires, Instituto de Biolog\u00eda Celular y Neurociencias (IBCN)  Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.\u00a0A.","family":"Serra","sequence":"additional","affiliation":[{"name":"Facultad de Medicina, Departamento de Toxicolog\u00eda y Farmacolog\u00eda, 1\u00aa C\u00e1tedra de Farmacolog\u00eda Universidad de Buenos Aires  Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.\u00a0N.","family":"Corsi","sequence":"additional","affiliation":[{"name":"CONICET\u2014Universidad de Buenos Aires, Centro de Estudios Farmacol\u00f3gicos y Bot\u00e1nicos (CEFyBO)  Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.\u00a0J.","family":"Molina","sequence":"additional","affiliation":[{"name":"Facultad de Medicina, Departamento de Toxicolog\u00eda y Farmacolog\u00eda, 1\u00aa C\u00e1tedra de Farmacolog\u00eda Universidad de Buenos Aires  Buenos Aires Argentina"},{"name":"CONICET\u2014Universidad de Buenos Aires, Centro de Estudios Farmacol\u00f3gicos y Bot\u00e1nicos (CEFyBO)  Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5251-3006","authenticated-orcid":false,"given":"L.\u00a0R.","family":"Guelman","sequence":"additional","affiliation":[{"name":"Facultad de Medicina, Departamento de Toxicolog\u00eda y Farmacolog\u00eda, 1\u00aa C\u00e1tedra de Farmacolog\u00eda Universidad de Buenos Aires  Buenos Aires Argentina"},{"name":"CONICET\u2014Universidad de Buenos Aires, Centro de Estudios Farmacol\u00f3gicos y Bot\u00e1nicos (CEFyBO)  Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,10,20]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnsys.2012.00054"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2016.08.011"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph20010591"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22020807"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2022.884197"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2006.05.001"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(13)61613\u2010X"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.alcohol.2021.03.006"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1260\/0957456001497535"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2018.01.020"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12640\u2010024\u201000707\u20101"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.15657"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/10253890290027895"},{"key":"e_1_2_12_15_1","first-page":"23","article-title":"Noise\u2010Induced Hearing Loss in Rats","volume":"3","author":"Cappaert N. 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