{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:44:02Z","timestamp":1772160242677,"version":"3.50.1"},"reference-count":46,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T00:00:00Z","timestamp":1761609600000},"content-version":"vor","delay-in-days":27,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J of Neuroscience"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The abnormalities in cerebellar circuit function within the Crus I\/II lobules in autism spectrum disorder (ASD) are widely recognized as critical contributors to impairments in motor behavior and social interaction. We here investigated the impact of prenatal valproic acid (VPA) exposure on facial stimulation\u2010evoked synaptic plasticity at cerebellar mossy fiber\u2010granule cell (MF\u2010GC) synapses in urethane\u2010anesthetized offspring mice in\u00a0vivo. When the GABAA receptor was blocked, 20\u2009Hz facial stimulation induced MF\u2010GC LTP in control mice, whereas the same stimulation paradigm triggered MF\u2010GC LTD in VPA\u2010treated offspring. Blockade of\n                    <jats:italic>N<\/jats:italic>\n                    \u2010methyl\u2010D\u2010aspartate receptors abolished LTP in control mice while unmasking LTD in VPA\u2010treated offspring. Notably, the facial stimulation\u2010induced LTD observed in VPA\u2010treated offspring was abolished by blocking group I metabotropic glutamate receptors, but not by the selective blockade of either mGluR1 or mGluR5 alone. Blockade of cannabinoid receptor 1 (CB1) or inhibition of diacylglycerol lipase (DGL) prevented the induction of LTD. Pharmacologically activating mGluR1\/5 or CB1 produced MF\u2010GC LTD and overwhelmed the facial stimulation\u2010induced LTD in VPA\u2010treated offspring mice. Conversely, mGluR1\/5 activation failed to induce LTD in control mice. Moreover, 20\u2009Hz facial stimulation induced MF\u2010GC LTP in the absence of mGluR1\/5 or CB1 receptor activity in VPA\u2010treated offspring mice. Immunohistochemical analyses revealed that the expression levels of mGluR1\/5 were significantly higher in the cerebellar GCs of VPA\u2010treated offspring compared to those of control mice. These results indicate that 20\u2009Hz facial stimulation induces MF\u2010GC LTD by enhancing the mGluR1\/5\u2010DGL\u2010CB1 receptor signaling cascade, thereby resulting in impairment of MF\u2010GC LTP in VPA\u2010treated offspring mice.\n                  <\/jats:p>","DOI":"10.1111\/ejn.70290","type":"journal-article","created":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T05:52:49Z","timestamp":1761717169000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Gestational VPA Exposure Impairs the Facial Stimulation\u2010Induced Cerebellar MF\u2010GC LTP by Enhancing mGluR1\/5\u2010CB1 Receptor Cascade in Offspring Mice"],"prefix":"10.1111","volume":"62","author":[{"given":"Yi\u2010Dan","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Physiology and Pathophysiology, College of Medicine Yanbian University  Yanji City Jilin Province China"},{"name":"Institute of Brain Science Jilin Medical University  Jilin City Jilin Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying\u2010Han","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pathophysiology, College of Medicine Yanbian University  Yanji City Jilin Province China"},{"name":"Institute of Brain Science Jilin Medical University  Jilin City Jilin Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming\u2010Ze","family":"Sun","sequence":"additional","affiliation":[{"name":"Institute of Brain Science Jilin Medical University  Jilin City Jilin Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute of Brain Science Jilin Medical University  Jilin City Jilin Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong\u2010Xue","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Affiliated Hospital of Yanbian University  Yanji City Jilin Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xu\u2010Dong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pathophysiology, College of Medicine Yanbian University  Yanji City Jilin Province China"},{"name":"Institute of Brain Science Jilin Medical University  Jilin City Jilin Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao\u2010Yue","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Brain Science Jilin Medical University  Jilin City Jilin Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun\u2010Tao","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Physiology, College of Basic Medicine Jilin Medical University  Jilin City Jilin Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen\u2010Cai","family":"Weng","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pathophysiology, College of Medicine Yanbian University  Yanji City Jilin Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun\u2010Ping","family":"Chu","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pathophysiology, College of Medicine Yanbian University  Yanji City Jilin Province China"},{"name":"Institute of Brain Science Jilin Medical University  Jilin City Jilin Province China"},{"name":"Department of Physiology, College of Basic Medicine Jilin Medical University  Jilin City Jilin Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan\u2010Hua","family":"Bing","sequence":"additional","affiliation":[{"name":"Functional Experiment 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