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Exposure to air pollution\u2014in particular to peaks of particulate matter (PM)\u2014has been associated with an increase in hospital admissions for MS onset and relapses and exacerbated neuroinflammation in MS patients. Here, in the MOG\n                    <jats:sub>35\u201355<\/jats:sub>\n                    \u2010induced experimental autoimmune encephalomyelitis (EAE) mouse model of MS, we tested the hypothesis that exposure to PM\n                    <jats:sub>10<\/jats:sub>\n                    might influence the disease course and severity in individuals with a predisposing background. Short\u2010term PM\n                    <jats:sub>10<\/jats:sub>\n                    exposures\u2014occurring either before immunization or during the presymptomatic phase\u2014did not modify disease manifestation in EAE mice, as assessed by clinical and neuropathological analyses. Yet, presymptomatic EAE\u2014but not healthy\u2014mice selectively showed increased disinhibited, risk\u2010taking, and novelty\u2010seeking behaviors early after being exposed to PM\n                    <jats:sub>10<\/jats:sub>\n                    . These data show a selective vulnerability of immunologically primed mice toward the effects of PM\n                    <jats:sub>10<\/jats:sub>\n                    , occurring before the emergence of overt motor impairment and presenting as specific behavioral alterations.\n                  <\/jats:p>","DOI":"10.1111\/ejn.70304","type":"journal-article","created":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T15:30:10Z","timestamp":1763566210000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Acute Particulate Matter (PM\n                    <sub>10<\/sub>\n                    ) Exposure Selectively Triggers Behavioral Alterations in the Presymptomatic Experimental Autoimmune Encephalomyelitis (EAE) Mouse Model of Multiple Sclerosis"],"prefix":"10.1111","volume":"62","author":[{"given":"Martino","family":"Bonato","sequence":"first","affiliation":[{"name":"Neuroscience Institute Cavalieri Ottolenghi (NICO)  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