{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T16:40:32Z","timestamp":1790095232682,"version":"4.0.1"},"reference-count":50,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T00:00:00Z","timestamp":1762732800000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81560281"],"award-info":[{"award-number":["81560281"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82260340"],"award-info":[{"award-number":["82260340"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81871333"],"award-info":[{"award-number":["81871333"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J of Neuroscience"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The glymphatic system (GS) serves as the brain's waste clearance pathway, with dysfunction implicated in neurodegenerative disorders\u2014particularly cerebral small vessel disease (CSVD). As hypertension is a modifiable risk factor strongly linked to CSVD progression, we compared magnetic resonance imaging\u2010derived (MRI\u2010derived) GS metrics between hypertensive and normotensive CSVD patients. So, in this study, we retrospectively analyzed 72 clinically diagnosed CSVD patients (37 hypertensive [CSVD_HT\n                    <jats:sup>+<\/jats:sup>\n                    ], 35 normotensive [CSVD_HT\n                    <jats:sup>\u2212<\/jats:sup>\n                    ]), and 40 age\u2010matched healthy controls (HCs). Key MRI\u2010derived GS indices included: perivascular space volume fraction (PVS\u2010VF), diffusivity along perivascular spaces (ALPS index), free water in white matter (FW\u2010WM), and choroid plexus volume (Chp). CSVD patients exhibited abnormal MRI\u2010derived indices, Compared to CSVD_HT\n                    <jats:sup>\u2212<\/jats:sup>\n                    individuals, CSVD_HT\n                    <jats:sup>+<\/jats:sup>\n                    were characterized by lower ALPS index, higher FW\u2010WM and hypertrophy of Chp. Random systolic blood pressure (SBP) negatively correlated with ALPS index (\n                    <jats:italic>r<\/jats:italic>\n                    \u2009=\u2009\u22120.220,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.055), while positively correlating with FW\u2010WM (\n                    <jats:italic>r<\/jats:italic>\n                    \u2009=\u20090.460,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001), and Chp volume (\n                    <jats:italic>r<\/jats:italic>\n                    \u2009=\u20090.310,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.006). Cognitive assessments revealed associations between ALPS index and memory scores (\n                    <jats:italic>r<\/jats:italic>\n                    \u2009=\u20090.280,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.020). These findings suggest that elevated SBP exacerbates GS impairment in CSVD, underscoring the critical role of blood pressure management. Longitudinal studies are needed to confirm these observations.\n                  <\/jats:p>","DOI":"10.1111\/ejn.70305","type":"journal-article","created":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T05:38:22Z","timestamp":1762839502000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["MRI Evaluation of Glymphatic Dysfunction in Cerebral Small Vessel Disease: Hypertensive vs. Normotensive Patients"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3616-7825","authenticated-orcid":false,"given":"Mingming","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Radiology Affiliated Hospital of Guizhou Medical University  Guiyang China"},{"name":"Key Laboratory of Brain Imaging Guizhou Medical University  Guiyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyue","family":"lyu","sequence":"additional","affiliation":[{"name":"Department of Radiology Affiliated Hospital of Guizhou Medical University  Guiyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Radiology Affiliated Hospital of Guizhou Medical University  Guiyang China"},{"name":"Key Laboratory of Brain Imaging Guizhou Medical University  Guiyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Radiology Affiliated Hospital of Guizhou Medical University  Guiyang China"},{"name":"Key Laboratory of Brain Imaging Guizhou Medical University  Guiyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,10]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature14432"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.212400"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000013077"},{"key":"e_1_2_13_5_1","article-title":"Dipy, a Library for the Analysis of Diffusion MRI Data","volume":"8","author":"Eleftherios G.","year":"2014","journal-title":"Frontiers in Neuroinformatics"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.28473"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000201349"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-48910-x"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2022.119329"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2022.1042824"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000209306"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2023.04.004"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/pcn.13557"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-024-01407-w"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-07318-3"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3003748"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12987-024-00525-9"},{"key":"e_1_2_13_18_1","article-title":"A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid \u03b2","volume":"4","author":"Jeffrey J. 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