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Depression, a prevalent comorbidity of chronic visceral pain, has been implicated as a potential risk factor of visceral hyperalgesia in previous clinical studies. However, animal studies that quantitatively and objectively investigated the impact of depression on visceral pain are scarce. In this study, a mice CP model was established via repeated administration of cerulein combined with ethanol, whereas a depressive phenotype was induced through chronic restraint stress (CRS). The concurrent manifestation of depression and CP was achieved by integrating CP modeling and CRS procedure in the same mice. Evaluations using conventional visceral pain metrics demonstrated that depression exacerbated visceral nociception in mice with CP. Through a three\u2010dimensional (3D) video\u2010based analysis of spontaneous behaviors and automated clustering, the CPCRS group exhibited significantly more pronounced visceral pain\u2010related behavioral alterations than the CP group. Furthermore, specific behavioral motifs associated with visceral pain were identified;\n                    <jats:italic>Grooming<\/jats:italic>\n                    and\n                    <jats:italic>Hunching<\/jats:italic>\n                    were intensified by visceral pain, whereas\n                    <jats:italic>step<\/jats:italic>\n                    ,\n                    <jats:italic>running<\/jats:italic>\n                    , and\n                    <jats:italic>left\u2010turn<\/jats:italic>\n                    were hindered by CP\u2010induced visceral pain. Overall, this study not only verified the role of depression in visceral pain hypersensitivity in mice but also revealed some previously unreported behavioral patterns linked to visceral pain.\n                  <\/jats:p>","DOI":"10.1111\/ejn.70308","type":"journal-article","created":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T00:10:09Z","timestamp":1764029409000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Depression Enhances Visceral Pain and Alters Behavioral Patterns in Chronic Pancreatitis Mice: An Objective Evaluation"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-1464-2178","authenticated-orcid":false,"given":"Zhijie","family":"Wang","sequence":"first","affiliation":[{"name":"CAS Key Laboratory of Brain Connectome and Manipulation, the Brain Cognition and Brain Disease Institute, Shenzhen Institute of Advanced Technology Chinese Academy of Sciences  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Shenzhen Neher Neural Plasticity Laboratory, Shenzhen\u2010Hong Kong Institute of Brain Science, the Brain Cognition and Brain Disease Institute, Shenzhen Institute of Advanced Technology Chinese Academy of Sciences  Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunming","family":"Tao","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Third Affiliated Hospital of Second Military Medical University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianwen","family":"Huang","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Brain Connectome and Manipulation, the Brain Cognition and Brain Disease Institute, Shenzhen Institute of Advanced Technology Chinese Academy of Sciences  Shenzhen Guangdong China"},{"name":"Shenzhen Key Laboratory of Drug Addiction, Shenzhen Neher Neural Plasticity Laboratory, Shenzhen\u2010Hong Kong Institute of Brain Science, the Brain Cognition 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