{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:44:04Z","timestamp":1772160244567,"version":"3.50.1"},"reference-count":67,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T00:00:00Z","timestamp":1763942400000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001677","name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J of Neuroscience"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Mounting evidence challenges the view that antibodies reach the brain solely via vascular leaks. Neurons, astrocytes and microglia appear able to assemble restricted and context\u2010dependent immunoglobulin repertoires via cryptic V(D)J recombination, splice\u2010and\u2010link RNA editing and retroelement\u2010assisted rearrangements. These endogenous antibodies have been associated with complement\u2010mediated pruning, receptor trafficking and astrocyte\u2013neuron metabolic coupling and may change after injury. However, causal evidence from in\u00a0vivo, cell\u2010type\u2013specific gain\u2010 or loss\u2010of\u2010function models remains sparse. Accordingly, we synthesise current evidence and outline testable, conservative hypotheses about when and how neural immunoglobulins might influence CNS function and disease.<\/jats:p>","DOI":"10.1111\/ejn.70330","type":"journal-article","created":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T23:10:24Z","timestamp":1764025824000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Neural Immunoglobulins Shape Brain Circuits"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4318-0817","authenticated-orcid":false,"given":"Michel","family":"Salzet","sequence":"first","affiliation":[{"name":"Univ. Lille, Inserm, CHU Lille, U1192\u2014Prot\u00e9omique R\u00e9ponse Inflammatoire Spectrom\u00e9trie de Masse\u2014PRISM  Lille France"},{"name":"Institut Universitaire de France, Minist\u00e8re de l'Enseignement sup\u00e9rieur, de la Recherche et de l'Innovation  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,24]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03892-7"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1734-20.2020"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8249(200006)47:6<694::AID-ANA2>3.0.CO;2-W"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2009.09.002"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0186842"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0502323102"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1326-5-42"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.882830"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-023-06037-y"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-023-05737-9"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(91)90220-S"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1708712"},{"key":"e_1_2_14_14_1","doi-asserted-by":"crossref","unstructured":"Dalmau J.&Rosenfeld M.R.(2020)Paraneoplastic Neurologic Syndromes Abeloff's Clinical Oncology.Elsevier 676\u2013687.","DOI":"10.1016\/B978-0-323-47674-4.00044-X"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/5.6.494"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2017.10.007"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199210000-00015"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2012.09.002"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2202-6-46"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2025.01.015"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/14737159.2017.1262260"},{"key":"e_1_2_14_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.1994.tb00313.x"},{"key":"e_1_2_14_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3915"},{"key":"e_1_2_14_24_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aad8373"},{"key":"e_1_2_14_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2007.12.004"},{"key":"e_1_2_14_26_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0167-10.2010"},{"key":"e_1_2_14_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/gene.1019"},{"key":"e_1_2_14_28_1","doi-asserted-by":"publisher","DOI":"10.3389\/neuro.05.016.2009"},{"key":"e_1_2_14_29_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1084152"},{"key":"e_1_2_14_30_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-neuro-060909-153244"},{"key":"e_1_2_14_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2006.07.008"},{"key":"e_1_2_14_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2020.577319"},{"key":"e_1_2_14_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/cns.12333"},{"key":"e_1_2_14_34_1","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.RA119.001604"},{"key":"e_1_2_14_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/mas.21719"},{"key":"e_1_2_14_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-025-02286-9"},{"key":"e_1_2_14_37_1","doi-asserted-by":"publisher","DOI":"10.1101\/2024.09.19.609743"},{"key":"e_1_2_14_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2011.02.054"},{"key":"e_1_2_14_39_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0810796106"},{"key":"e_1_2_14_40_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-025-03457-9"},{"key":"e_1_2_14_41_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.2.330"},{"key":"e_1_2_14_42_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-017-0894-6"},{"key":"e_1_2_14_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2010.12.012"},{"key":"e_1_2_14_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-010-0572-7"},{"key":"e_1_2_14_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12017-009-8099-5"},{"key":"e_1_2_14_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-021-03338-6"},{"key":"e_1_2_14_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2009.08.013"},{"key":"e_1_2_14_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.24369"},{"key":"e_1_2_14_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(90)90043-A"},{"key":"e_1_2_14_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2012.03.026"},{"key":"e_1_2_14_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2941"},{"key":"e_1_2_14_52_1","doi-asserted-by":"publisher","DOI":"10.26508\/lsa.202101154"},{"key":"e_1_2_14_53_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2002.00840.x"},{"key":"e_1_2_14_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature16549"},{"key":"e_1_2_14_55_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-017-1050-z"},{"key":"e_1_2_14_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2024.08.007"},{"key":"e_1_2_14_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.10.036"},{"key":"e_1_2_14_58_1","first-page":"161","article-title":"Expression of RAG\u20101 in Brain During Mouse Development","volume":"36","author":"Sun J.\u2010G.","year":"2007","journal-title":"Zhejiang Da Xue Xue Bao Yi Xue Ban\u2009=\u2009Journal of Zhejiang University (Medical Sciences)"},{"key":"e_1_2_14_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-022-00684-6"},{"key":"e_1_2_14_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(17)30470-2"},{"key":"e_1_2_14_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(94)90340-9"},{"key":"e_1_2_14_62_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.1994.tb00615.x"},{"key":"e_1_2_14_63_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41594-024-01387-3"},{"key":"e_1_2_14_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2022.12.019"},{"key":"e_1_2_14_65_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-016-0611-x"},{"key":"e_1_2_14_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2022.06.023"},{"key":"e_1_2_14_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(02)03479-0"},{"key":"e_1_2_14_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2013.06.005"}],"container-title":["European Journal of Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ejn.70330","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T01:52:36Z","timestamp":1765504356000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ejn.70330"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":67,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1111\/ejn.70330"],"URL":"https:\/\/doi.org\/10.1111\/ejn.70330","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/EJN.70330\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.70330\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.70330\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.70330\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.70330\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.70330\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.70330\/v2\/decision1","asserted-by":"object"}]},"ISSN":["0953-816X","1460-9568"],"issn-type":[{"value":"0953-816X","type":"print"},{"value":"1460-9568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"2025-09-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70330"}}