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Optimized focal muscle vibration (o\u2010fmv) paradigms can enhance motor control of goal\u2010directed movements, potentially influencing the proprioceptive contribution needed for visual\u2013proprioceptive integration during planning and execution stages of motion. We examined whether o\u2010fmv affects goal\u2010directed movements when visual information is available in real time or when it needs to be memorized. We applied the o\u2010fmv to the shoulder muscles in healthy participants to affect their proprioception. Then, we assessed immediate and 1\u2010week\u2010later effects on upper limb aiming toward visual targets. Movements were prepared with vision and executed either with real\u2010time or memorized visual information. O\u2010fmv improved mean speed, smoothness, and accuracy primarily when movements were performed with real\u2010time visual information. These improvements began immediately and continued to increase after 1\u2009week. Minimal effects were observed when movements relied on memorized visual information. Therefore, o\u2010fmv produces lasting improvements in motor control of goal\u2010directed movements supported by real\u2010time visual information. Our findings suggest that o\u2010fmv may enhance the brain's processing of proprioceptive information used during motion planning and execution, potentially leading to long\u2010term changes. These effects might involve stream pathways that coordinate goal\u2010directed actions by integrating real\u2010time visual information with proprioceptive inputs.<\/jats:p>","DOI":"10.1111\/ejn.70335","type":"journal-article","created":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T14:45:49Z","timestamp":1763563549000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Optimized Sensorimotor Activation Enhances the Control of Goal\u2010Directed Aiming Mediated by Real\u2010Time Visuomotor Transformations"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9081-8513","authenticated-orcid":false,"given":"Roberto","family":"Panichi","sequence":"first","affiliation":[{"name":"Department of Medicine and Surgery, Section of Human Physiology and Biochemistry University of Perugia  Perugia 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