{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:44:02Z","timestamp":1772160242836,"version":"3.50.1"},"reference-count":134,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T00:00:00Z","timestamp":1764374400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J of Neuroscience"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Parkinson's disease (PD) is a neurodegenerative disorder with rapidly increasing prevalence, characterized by dopaminergic neuronal loss and \u03b1\u2010synuclein aggregation. Current therapies provide only symptomatic benefit and do not alter the disease course. MicroRNAs (miRNAs), small noncoding RNAs that regulate gene expression, are increasingly recognized as key modulators of PD pathogenesis, influencing oxidative stress, mitochondrial dysfunction, neuroinflammation, and proteostasis. Therapeutic modulation of miRNAs in PD has centered on two complementary approaches: miRNA inhibitors (antagomiRs), which silence pathogenic miRNAs, and miRNA mimics (agomiRs), which restore the activity of protective ones. This review integrates current insights into miRNA dysregulation in PD and evaluates the hurdles limiting therapeutic translation. Specific miRNAs such as miR\u20107, miR\u2010153, and miR\u201034b\/c directly regulate SNCA expression, whereas others influence clearance pathways and stress responses. Although miRNA\u2010based therapeutics offer considerable promise, their clinical utility remains constrained by challenges of delivery, specificity, and standardization. This review highlights strategies to harness miRNA modulation as a targeted therapeutic avenue in PD.<\/jats:p>","DOI":"10.1111\/ejn.70343","type":"journal-article","created":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T05:46:13Z","timestamp":1764481573000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Expanding Therapeutic Horizons in Parkinson's Disease Through MicroRNA\u2010Based Interventions: A Comprehensive Review"],"prefix":"10.1111","volume":"62","author":[{"given":"Utkarsh\u00a0U.","family":"Bhamare","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Shobhaben Pratapbhai Patel School of Pharmacy &amp; Technology Management SVKM's NMIMS University  Mumbai Maharashtra India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anishka","family":"Talpade","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Shobhaben Pratapbhai Patel School of Pharmacy &amp; Technology Management SVKM's NMIMS University  Mumbai Maharashtra India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ravindra\u00a0Babu","family":"Pingili","sequence":"additional","affiliation":[{"name":"Department of Pharmacology SVKM's NMIMS University School of Pharmacy and Technology Management  Dist\u2010Dhule Maharashtra India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7486-5275","authenticated-orcid":false,"given":"Mahesh\u00a0B.","family":"Palkar","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Shobhaben Pratapbhai Patel School of Pharmacy &amp; Technology Management SVKM's NMIMS University  Mumbai Maharashtra India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,29]]},"reference":[{"key":"e_1_2_17_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-04298-0_4"},{"key":"e_1_2_17_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/07315724.2019.1683379"},{"key":"e_1_2_17_4_1","doi-asserted-by":"publisher","DOI":"10.4103\/sja.sja_529_23"},{"key":"e_1_2_17_5_1","doi-asserted-by":"publisher","DOI":"10.48048\/tis.2025.9422"},{"key":"e_1_2_17_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2013.73"},{"key":"e_1_2_17_7_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/683920"},{"key":"e_1_2_17_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-024-04261-x"},{"key":"e_1_2_17_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2016.12.004"},{"key":"e_1_2_17_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(04)00045-5"},{"key":"e_1_2_17_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2012.04.014"},{"key":"e_1_2_17_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/NRL.0b013e31823d7abb"},{"key":"e_1_2_17_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2024.1386608"},{"key":"e_1_2_17_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/15476286.2023.2288741"},{"key":"e_1_2_17_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/scipharm87010006"},{"key":"e_1_2_17_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-023-06826-5"},{"key":"e_1_2_17_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ensci.2018.09.002"},{"key":"e_1_2_17_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-023-05672-9"},{"key":"e_1_2_17_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2017.00232"},{"key":"e_1_2_17_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb.2230"},{"key":"e_1_2_17_21_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1020736131907"},{"key":"e_1_2_17_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom15050658"},{"key":"e_1_2_17_23_1","doi-asserted-by":"publisher","DOI":"10.3233\/JPD-130230"},{"key":"e_1_2_17_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkad1142"},{"key":"e_1_2_17_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-020-03166-0"},{"key":"e_1_2_17_26_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.086827"},{"key":"e_1_2_17_27_1","doi-asserted-by":"publisher","DOI":"10.4061\/2011\/247467"},{"key":"e_1_2_17_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/9783527803781.ch6"},{"key":"e_1_2_17_29_1","doi-asserted-by":"publisher","DOI":"10.4061\/2011\/708404"},{"key":"e_1_2_17_30_1","doi-asserted-by":"publisher","DOI":"10.1080\/14728222.2025.2507034"},{"key":"e_1_2_17_31_1","doi-asserted-by":"publisher","DOI":"10.1586\/14737175.2014.920235"},{"key":"e_1_2_17_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12017-014-8294-x"},{"key":"e_1_2_17_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2019.118449"},{"key":"e_1_2_17_34_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.00356"},{"key":"e_1_2_17_35_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24021256"},{"key":"e_1_2_17_36_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2021.4736"},{"key":"e_1_2_17_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb.1552"},{"key":"e_1_2_17_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2009.10.025"},{"key":"e_1_2_17_39_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1732-12.2012"},{"key":"e_1_2_17_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-019-1809-5"},{"key":"e_1_2_17_41_1","doi-asserted-by":"publisher","DOI":"10.14336\/AD.2021.0517"},{"key":"e_1_2_17_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/cns.14763"},{"key":"e_1_2_17_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2009.06404.x"},{"key":"e_1_2_17_44_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells13121063"},{"key":"e_1_2_17_45_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells12071012"},{"key":"e_1_2_17_46_1","doi-asserted-by":"publisher","DOI":"10.2174\/1566524023666220817145638"},{"key":"e_1_2_17_47_1","doi-asserted-by":"publisher","DOI":"10.3390\/toxins17040204"},{"key":"e_1_2_17_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-025-02145-7"},{"key":"e_1_2_17_49_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0906277106"},{"key":"e_1_2_17_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2014.12.014"},{"key":"e_1_2_17_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-024-02283-x"},{"key":"e_1_2_17_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2010.10.003"},{"key":"e_1_2_17_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-025-03338-y"},{"key":"e_1_2_17_54_1","doi-asserted-by":"crossref","unstructured":"Kaurani L. J.Zhou R.Pradhan et\u00a0al.2024. \u201cInhibition of MicroRNA\u2010129\u20105p Promotes Neuroinflammation and Cognitive Impairment.\u201d","DOI":"10.21203\/rs.3.rs-3870232\/v1"},{"key":"e_1_2_17_55_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-016-0121-4"},{"key":"e_1_2_17_56_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20236055"},{"key":"e_1_2_17_57_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-025-00797-1"},{"key":"e_1_2_17_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/mtna.2015.23"},{"key":"e_1_2_17_59_1","doi-asserted-by":"publisher","DOI":"10.2217\/pgs-2019-0089"},{"key":"e_1_2_17_60_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18122698"},{"key":"e_1_2_17_61_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21197282"},{"key":"e_1_2_17_62_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms150915845"},{"key":"e_1_2_17_63_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2021.744942"},{"key":"e_1_2_17_64_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10495-025-02117-w"},{"key":"e_1_2_17_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2011.10.017"},{"key":"e_1_2_17_66_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells11050851"},{"key":"e_1_2_17_67_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.719807"},{"key":"e_1_2_17_68_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom15030376"},{"key":"e_1_2_17_69_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.15299"},{"key":"e_1_2_17_70_1","first-page":"189","volume-title":"Complications in Neurosurgery","author":"Magown P.","year":"2018"},{"key":"e_1_2_17_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2017.08.017"},{"key":"e_1_2_17_72_1","doi-asserted-by":"publisher","DOI":"10.1002\/smtd.202402058"},{"key":"e_1_2_17_73_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddr210"},{"issue":"7","key":"e_1_2_17_74_1","article-title":"Navigating Challenges and Opportunities in Multi\u2010Omics Integration for Personalized Healthcare","volume":"12","author":"Mohr A. E.","year":"2024","journal-title":"Biomedicine"},{"key":"e_1_2_17_75_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41559-016-0027"},{"key":"e_1_2_17_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cnr.2006.09.006"},{"key":"e_1_2_17_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2016.07.010"},{"key":"e_1_2_17_78_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-019-00714-7"},{"key":"e_1_2_17_79_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10495-010-0476-x"},{"key":"e_1_2_17_80_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0051111"},{"key":"e_1_2_17_81_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2018.00402"},{"key":"e_1_2_17_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2021.101374"},{"key":"e_1_2_17_83_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox12020517"},{"key":"e_1_2_17_84_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24119547"},{"key":"e_1_2_17_85_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms13051000"},{"key":"e_1_2_17_86_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26073399"},{"key":"e_1_2_17_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2014.11.019"},{"key":"e_1_2_17_88_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.144337"},{"key":"e_1_2_17_89_1","doi-asserted-by":"publisher","DOI":"10.3934\/Neuroscience.2023017"},{"key":"e_1_2_17_90_1","doi-asserted-by":"publisher","DOI":"10.1097\/nen.0b013e31802d6da9"},{"key":"e_1_2_17_91_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2023.1226413"},{"key":"e_1_2_17_92_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2016.00128"},{"key":"e_1_2_17_93_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2915"},{"key":"e_1_2_17_94_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.0030235"},{"key":"e_1_2_17_95_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17060904"},{"key":"e_1_2_17_96_1","doi-asserted-by":"publisher","DOI":"10.1111\/nan.12864"},{"key":"e_1_2_17_97_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2022.995997"},{"key":"e_1_2_17_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0072-9752(07)83013-2"},{"key":"e_1_2_17_99_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41531-024-00791-2"},{"key":"e_1_2_17_100_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-15-0263-7_8"},{"key":"e_1_2_17_101_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1496304"},{"key":"e_1_2_17_102_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40263-013-0053-2"},{"key":"e_1_2_17_103_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.736978"},{"key":"e_1_2_17_104_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.1034072"},{"key":"e_1_2_17_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2020.113394"},{"key":"e_1_2_17_106_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19123824"},{"key":"e_1_2_17_107_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3900-15.2016"},{"key":"e_1_2_17_108_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23071825"},{"key":"e_1_2_17_109_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells9040841"},{"key":"e_1_2_17_110_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-024-07092-7"},{"key":"e_1_2_17_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ncrna.2025.05.002"},{"key":"e_1_2_17_112_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1789.2007.00803.x"},{"key":"e_1_2_17_113_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-025-04737-4"},{"key":"e_1_2_17_114_1","doi-asserted-by":"crossref","unstructured":"Wang H. H.Zhou K.Chai et\u00a0al.2025. \u201cThe Burden and Impact of Intervention Strategies for Heart Failure in China (2025\u20102035): A Health\u2010Augmented Macroeconomic Modeling Study.\u201d medRxiv.https:\/\/doi.org\/10.1101\/2025.04.04.25325219.","DOI":"10.2139\/ssrn.5194341"},{"key":"e_1_2_17_115_1","doi-asserted-by":"publisher","DOI":"10.1111\/gtc.12764"},{"key":"e_1_2_17_116_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2015.08.025"},{"key":"e_1_2_17_117_1","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2014.112"},{"key":"e_1_2_17_118_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4269"},{"key":"e_1_2_17_119_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-812433-8.00009-5"},{"key":"e_1_2_17_120_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.8b00683"},{"key":"e_1_2_17_121_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2016.00298"},{"key":"e_1_2_17_122_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2013.09.027"},{"key":"e_1_2_17_123_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26052304"},{"key":"e_1_2_17_124_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-018-1053-4"},{"key":"e_1_2_17_125_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201900363R"},{"key":"e_1_2_17_126_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12033-007-9013-8"},{"key":"e_1_2_17_127_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2019.04.004"},{"key":"e_1_2_17_128_1","doi-asserted-by":"crossref","unstructured":"Zhang H. X.Fu X.Ren et\u00a0al.2024. \u201cThe Diagnostic Value of Blood miR\u2010132\u20103p Level in Patients With Alzheimer's Disease.\u201d","DOI":"10.21203\/rs.3.rs-4449291\/v1"},{"key":"e_1_2_17_129_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2021.644507"},{"key":"e_1_2_17_130_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/938348"},{"key":"e_1_2_17_131_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNR.0000000000001494"},{"key":"e_1_2_17_132_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/1743183"},{"key":"e_1_2_17_133_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-016-0094-3"},{"key":"e_1_2_17_134_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-016-0094-3"},{"key":"e_1_2_17_135_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2021.646072"}],"container-title":["European Journal of Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ejn.70343","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T06:26:22Z","timestamp":1766730382000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ejn.70343"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,29]]},"references-count":134,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1111\/ejn.70343"],"URL":"https:\/\/doi.org\/10.1111\/ejn.70343","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/EJN.70343\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.70343\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.70343\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.70343\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.70343\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.70343\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.70343\/v1\/review3","asserted-by":"object"}]},"ISSN":["0953-816X","1460-9568"],"issn-type":[{"value":"0953-816X","type":"print"},{"value":"1460-9568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,29]]},"assertion":[{"value":"2025-06-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70343"}}