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It is believed that the medial entorhinal cortex (MEC) mainly captures distal visual cues, while the lateral entorhinal cortex (LEC) apprehends most proximal visual cues, both of which cooperatively construct a coordinate system to encode spatial information. However, it remains unclear how entorhinal\u2013hippocampal circuit jointly generate spatial representation from distal and proximal visual cues and further guide navigational decision\u2010making. To fill these gaps, we developed a model based on the two\u2010dimensional continuous attractor network. In the model, allocentric velocity inputs drive grid\u2010cell attractor dynamics anchored to distal cues in the MEC, while LEC populations encode the positions of proximal cues. Their convergence in hippocampal place cells gives rise to a population code of self\u2010location and object location, enabling a simple vector\u2010subtraction mechanism that supports memory\u2010based, goal\u2010directed navigation. To verify the model, we implemented it on a robotics platform. Through systematic biorobotics experiments, the model successfully replicated key findings from biological studies, including distal cue\u2013controlled rotation of grid\u2013place representations, object\u2010related and proximal cue\u2013coherent responses in the LEC pathway and both coherent and irregular remapping patterns at the hippocampal level. Furthermore, it demonstrated a plausible navigation strategy. Overall, these results offer a mechanistic, population\u2010level explanation of how distal and proximal cues can be integrated to maintain stable allocentric representations and support flexible navigation. The biorobotics implementation further demonstrates the value of embodied approaches for testing computational hypotheses of spatial cognition.<\/jats:p>","DOI":"10.1111\/ejn.70344","type":"journal-article","created":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T04:39:21Z","timestamp":1767674361000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Mechanistic Integration of Distal and Proximal Cues in the Rodent Entorhinal\u2013Hippocampal Circuit: Insights From a Biorobotics Model"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8527-733X","authenticated-orcid":false,"given":"Yani","family":"Chen","sequence":"first","affiliation":[{"name":"School of Mathematics and Information Science Guangzhou University  Guangzhou China"},{"name":"Machine Life and Intelligence Research Center Guangzhou University  Guangzhou China"},{"name":"School of Computing and Mathematical Sciences University of Leicester  Leicester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mu","family":"Hua","sequence":"additional","affiliation":[{"name":"Machine Life and Intelligence Research Center Guangzhou University  Guangzhou China"},{"name":"School of Computing and Mathematical Sciences University of Leicester  Leicester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyan","family":"Qin","sequence":"additional","affiliation":[{"name":"School of Mathematics and Information Science Guangzhou University  Guangzhou China"},{"name":"Machine Life and Intelligence Research Center Guangzhou University  Guangzhou China"},{"name":"School of Computing and Mathematical Sciences University of Leicester  Leicester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigang","family":"Yue","sequence":"additional","affiliation":[{"name":"School of Computing and Mathematical Sciences University of Leicester  Leicester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuelong","family":"Sun","sequence":"additional","affiliation":[{"name":"School of Mathematics and Information Science Guangzhou University  Guangzhou China"},{"name":"Machine Life and Intelligence Research Center Guangzhou University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jigen","family":"Peng","sequence":"additional","affiliation":[{"name":"School of Mathematics and Information Science Guangzhou University  Guangzhou China"},{"name":"Machine Life and Intelligence Research Center Guangzhou University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,5]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.23506"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2012.0526"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1201652"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1000291"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.22547"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2016.06.043"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4657"},{"key":"e_1_2_10_9_1","first-page":"127","volume-title":"Spatial and Nonspatial Representations in the Lateral Entorhinal Cortex, in Space, Time and Memory in the Hippocampal Formation","author":"Deshmukh S. 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