{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T21:22:39Z","timestamp":1786828959206,"version":"build-2736575974"},"reference-count":235,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T00:00:00Z","timestamp":1766966400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T00:00:00Z","timestamp":1766966400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J of Neuroscience"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Type 3 diabetes, a term that underscores the pathological connection between Type 2 diabetes mellitus (T2DM) and Alzheimer's disease (\n                    <jats:sc>AD<\/jats:sc>\n                    ), emphasizes the role of cerebral insulin resistance and metabolic dysfunction in neuron degeneration. Cerebral insulin resistance impairs Akt signaling, leading to the suppression of GSK\u20103\u03b2 activity, enhancement of tau hyperphosphorylation and neurofibrillary tangle formation. Concurrent impaired GLUT\u20103\/4 translocation, mitochondrial function, and amyloid\u2010\u03b2 clearance exacerbate oxidative stress and plaque deposition. Collectively, these disruptions compromise synaptic plasticity and cognition, accelerating AD progression. Moreover, activation of AGE\u2013RAGE\u2013NF\u2010\u03baB signaling amplifies neuroinflammation, further aggravating tau and A\u03b2 pathology. This interaction activates downstream MAPK, ERK1\/2, and JNK\/STAT pathways, which in turn stimulate transcription factors such as NF\u2010\u03baB, TGF\u2010\u03b2, HIF\u20101\u03b1, and AP\u20101. The resulting cascade promotes oxidative stress, neuroinflammation, and PI3K\/Akt\/IRS\u20101 signaling impairment. Together, these interconnected pathways accelerate neuronal loss and cognitive decline. Emerging evidence indicates that natural bioactive compounds offer therapeutic benefits in\n                    <jats:sc>AD<\/jats:sc>\n                    by attenuating AGE\u2013RAGE\u2013mediated oxidative stress, neuroinflammation, and cerebral insulin resistance, thereby reducing amyloid\u2010\u03b2 accumulation and tau hyperphosphorylation. This review highlights the AGE\u2013RAGE axis as a critical molecular mediator connecting T2DM and\n                    <jats:sc>AD<\/jats:sc>\n                    , orchestrating neuroinflammation, mitochondrial dysfunction, and tau hyperphosphorylation. Therapeutic strategies aimed at inhibiting AGE formation or blocking RAGE activation represent promising approaches to attenuate cognitive decline associated with Type 3 diabetes.\n                  <\/jats:p>","DOI":"10.1111\/ejn.70364","type":"journal-article","created":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T11:41:55Z","timestamp":1767008515000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Type 3 Diabetes: A Molecular Link Between Cerebral Insulin Resistance and Neurodegeneration via AGE\u2013RAGE Signaling"],"prefix":"10.1111","volume":"63","author":[{"given":"Ankit","family":"Verma","sequence":"first","affiliation":[{"name":"Department of Pharmacology, School of Pharmaceutical Education and Research Jamia Hamdard  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4013-6626","authenticated-orcid":false,"given":"Manju","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Pharmaceutical Education and Research Jamia Hamdard  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ozair","family":"Alam","sequence":"additional","affiliation":[{"name":"Medicinal Chemistry and Molecular Modelling Lab, Department of Pharmaceutical Chemistry, School of Pharmaceutical Education and Research Jamia Hamdard, Hamdard Nagar  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarique","family":"Anwer","sequence":"additional","affiliation":[{"name":"Department of Public Health, College of Applied Medical Sciences University of Bisha  Bisha Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,29]]},"reference":[{"key":"e_1_2_15_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102125.2010.03830.x"},{"key":"e_1_2_15_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2015.05.004"},{"key":"e_1_2_15_4_1","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S367229"},{"key":"e_1_2_15_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28020502"},{"key":"e_1_2_15_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2021.101899"},{"key":"e_1_2_15_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12328"},{"key":"e_1_2_15_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2022.110206"},{"key":"e_1_2_15_9_1","doi-asserted-by":"publisher","DOI":"10.1257\/pandp.20241061"},{"key":"e_1_2_15_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12964\u2010023\u201001048\u2010w"},{"key":"e_1_2_15_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2017.185"},{"key":"e_1_2_15_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fbio.2025.106165"},{"key":"e_1_2_15_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23031582"},{"key":"e_1_2_15_14_1","doi-asserted-by":"publisher","DOI":"10.5114\/aoms.2015.56342"},{"key":"e_1_2_15_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11050936"},{"key":"e_1_2_15_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2019.01.002"},{"key":"e_1_2_15_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2020.560375"},{"key":"e_1_2_15_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2023.1155175"},{"key":"e_1_2_15_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpls.2021.720867"},{"key":"e_1_2_15_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox14091044"},{"key":"e_1_2_15_21_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc17\u20101962"},{"key":"e_1_2_15_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.7b00058"},{"key":"e_1_2_15_23_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a009191"},{"key":"e_1_2_15_24_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523\u20101755.2002.00115.x"},{"key":"e_1_2_15_25_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00060.2010"},{"key":"e_1_2_15_26_1","doi-asserted-by":"publisher","DOI":"10.14283\/jpad.2018.18"},{"key":"e_1_2_15_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10571\u2010015\u20100233\u20103"},{"key":"e_1_2_15_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu14071425"},{"key":"e_1_2_15_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.115298"},{"key":"e_1_2_15_30_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26146693"},{"key":"e_1_2_15_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/cns.12503"},{"key":"e_1_2_15_32_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2018.00383"},{"key":"e_1_2_15_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.22620"},{"key":"e_1_2_15_34_1","doi-asserted-by":"publisher","DOI":"10.30773\/pi.2022.0287"},{"key":"e_1_2_15_35_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u20102007\u201012208"},{"key":"e_1_2_15_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2019.01.030"},{"key":"e_1_2_15_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13659\u2010014\u20100044\u20100"},{"key":"e_1_2_15_38_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu9090984"},{"key":"e_1_2_15_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2019.152643"},{"key":"e_1_2_15_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/emm.2013.147"},{"key":"e_1_2_15_41_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22105347"},{"key":"e_1_2_15_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.14647"},{"key":"e_1_2_15_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002\u20109440(10)64354\u20104"},{"key":"e_1_2_15_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125\u2010010\u20101971\u2010x"},{"key":"e_1_2_15_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2011.09.002"},{"key":"e_1_2_15_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265\u2010016\u20100674\u20100"},{"key":"e_1_2_15_47_1","doi-asserted-by":"publisher","DOI":"10.1177\/193229680800200619"},{"key":"e_1_2_15_48_1","doi-asserted-by":"publisher","DOI":"10.3233\/JPD\u2010130230"},{"key":"e_1_2_15_49_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974\u2010020\u201001981\u20104"},{"key":"e_1_2_15_50_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27020547"},{"key":"e_1_2_15_51_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules30030694"},{"key":"e_1_2_15_52_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.931473"},{"key":"e_1_2_15_53_1","doi-asserted-by":"publisher","DOI":"10.18388\/abp.2020_5963"},{"key":"e_1_2_15_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.postharvbio.2023.112634"},{"key":"e_1_2_15_55_1","doi-asserted-by":"publisher","DOI":"10.3233\/JHD\u2010170264"},{"key":"e_1_2_15_56_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddy017"},{"key":"e_1_2_15_57_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.0c00811"},{"key":"e_1_2_15_58_1","doi-asserted-by":"publisher","DOI":"10.1177\/1559325818761455"},{"key":"e_1_2_15_59_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0230450100"},{"key":"e_1_2_15_60_1","doi-asserted-by":"publisher","DOI":"10.1111\/1541\u20104337.12376"},{"key":"e_1_2_15_61_1","doi-asserted-by":"publisher","DOI":"10.1177\/1753425919856078"},{"key":"e_1_2_15_62_1","doi-asserted-by":"publisher","DOI":"10.3390\/cimb45040225"},{"key":"e_1_2_15_63_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21176275"},{"key":"e_1_2_15_64_1","doi-asserted-by":"publisher","DOI":"10.3390\/biology11060943"},{"key":"e_1_2_15_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ekir.2017.11.009"},{"key":"e_1_2_15_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgr.2020.08.005"},{"key":"e_1_2_15_67_1","doi-asserted-by":"publisher","DOI":"10.2174\/1570159X20666220201094547"},{"key":"e_1_2_15_68_1","doi-asserted-by":"publisher","DOI":"10.3934\/genet.2017.2.103"},{"key":"e_1_2_15_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phyplu.2022.100379"},{"key":"e_1_2_15_70_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0142483"},{"key":"e_1_2_15_71_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2019.00017"},{"key":"e_1_2_15_72_1","doi-asserted-by":"publisher","DOI":"10.2174\/092986708785909111"},{"key":"e_1_2_15_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imbio.2012.09.005"},{"key":"e_1_2_15_74_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.12202"},{"key":"e_1_2_15_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2010.05.026"},{"key":"e_1_2_15_76_1","doi-asserted-by":"publisher","DOI":"10.3945\/an.116.013912"},{"key":"e_1_2_15_77_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00217\u2010012\u20101738\u20103"},{"key":"e_1_2_15_78_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.137661"},{"key":"e_1_2_15_79_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.31.19547"},{"key":"e_1_2_15_80_1","doi-asserted-by":"publisher","DOI":"10.1139\/cjpp\u20102015\u20100073"},{"key":"e_1_2_15_81_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc11\u20100442"},{"key":"e_1_2_15_82_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells11233730"},{"key":"e_1_2_15_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sajb.2022.06.062"},{"key":"e_1_2_15_84_1","unstructured":"International Diabetes Federation. n.d. \u201cDiabetes Facts and Figures.\u201d Accessed April 21 2025.https:\/\/idf.org\/about\u2010diabetes\/diabetes\u2010facts\u2010figures\/."},{"key":"e_1_2_15_85_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12906\u2010017\u20101641\u20103"},{"key":"e_1_2_15_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.steroids.2011.10.009"},{"key":"e_1_2_15_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2024.106385"},{"key":"e_1_2_15_88_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2014.00093"},{"key":"e_1_2_15_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharep.2017.11.020"},{"key":"e_1_2_15_90_1","doi-asserted-by":"publisher","DOI":"10.37349\/en.2025.100682"},{"key":"e_1_2_15_91_1","doi-asserted-by":"publisher","DOI":"10.2991\/jegh.k.191028.001"},{"key":"e_1_2_15_92_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.5501"},{"key":"e_1_2_15_93_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22136904"},{"key":"e_1_2_15_94_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12272\u2010011\u20100319\u20105"},{"key":"e_1_2_15_95_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11357\u2010009\u20109124\u20101"},{"key":"e_1_2_15_96_1","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2013.0016"},{"key":"e_1_2_15_97_1","doi-asserted-by":"publisher","DOI":"10.2174\/1573399819666230413094200"},{"key":"e_1_2_15_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2006.05.020"},{"key":"e_1_2_15_99_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.1208763"},{"key":"e_1_2_15_100_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u2010200185"},{"key":"e_1_2_15_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2008.11.016"},{"key":"e_1_2_15_102_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12928"},{"key":"e_1_2_15_103_1","doi-asserted-by":"publisher","DOI":"10.1038\/35012636"},{"key":"e_1_2_15_104_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27248793"},{"key":"e_1_2_15_105_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28145527"},{"key":"e_1_2_15_106_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10571\u2010023\u201001335\u20107"},{"key":"e_1_2_15_107_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26010403"},{"key":"e_1_2_15_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcmed.2021.05.005"},{"key":"e_1_2_15_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2011.02.003"},{"key":"e_1_2_15_110_1","doi-asserted-by":"publisher","DOI":"10.7324\/JAPS.2020.10801"},{"key":"e_1_2_15_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2010.11.014"},{"key":"e_1_2_15_112_1","doi-asserted-by":"publisher","DOI":"10.14336\/AD.2021.1115"},{"key":"e_1_2_15_113_1","doi-asserted-by":"publisher","DOI":"10.2147\/DMSO.S299375"},{"key":"e_1_2_15_114_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2018.06.024"},{"key":"e_1_2_15_115_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.103306"},{"key":"e_1_2_15_116_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmr.2814"},{"key":"e_1_2_15_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.114581"},{"key":"e_1_2_15_118_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2011.02.076"},{"key":"e_1_2_15_119_1","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.2001.7732"},{"key":"e_1_2_15_120_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI79742"},{"key":"e_1_2_15_121_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.53.10.2662"},{"key":"e_1_2_15_122_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13197\u2010014\u20101704\u20100"},{"key":"e_1_2_15_123_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11418\u2010021\u201001602\u20101"},{"key":"e_1_2_15_124_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2022.1002710"},{"key":"e_1_2_15_125_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnint.2013.00059"},{"key":"e_1_2_15_126_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2008.06.124"},{"key":"e_1_2_15_127_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.13411"},{"key":"e_1_2_15_128_1","doi-asserted-by":"publisher","DOI":"10.1080\/1071576021000016463"},{"key":"e_1_2_15_129_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/3085756"},{"key":"e_1_2_15_130_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2024.156616"},{"key":"e_1_2_15_131_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2017.00118"},{"key":"e_1_2_15_132_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2018.12.027"},{"key":"e_1_2_15_133_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2022.07.034"},{"key":"e_1_2_15_134_1","doi-asserted-by":"publisher","DOI":"10.1080\/87559129.2013.853774"},{"key":"e_1_2_15_135_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21093165"},{"key":"e_1_2_15_136_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1470879"},{"key":"e_1_2_15_137_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23042008"},{"key":"e_1_2_15_138_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13410\u2010020\u201000838\u2010z"},{"key":"e_1_2_15_139_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241814177"},{"key":"e_1_2_15_140_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.921611"},{"key":"e_1_2_15_141_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2013.12.016"},{"key":"e_1_2_15_142_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2016.11.056"},{"key":"e_1_2_15_143_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbabio.2008.07.003"},{"key":"e_1_2_15_144_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2011.01.007"},{"key":"e_1_2_15_145_1","doi-asserted-by":"publisher","DOI":"10.1080\/14756366.2021.2024526"},{"key":"e_1_2_15_146_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11011\u2010020\u201000540\u20103"},{"key":"e_1_2_15_147_1","doi-asserted-by":"publisher","DOI":"10.3390\/foods13244045"},{"key":"e_1_2_15_148_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2024.102383"},{"key":"e_1_2_15_149_1","doi-asserted-by":"publisher","DOI":"10.1038\/nutd.2014.39"},{"key":"e_1_2_15_150_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5FO01372K"},{"key":"e_1_2_15_151_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006\u2010291X(69)90685\u20108"},{"key":"e_1_2_15_152_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749\u20106632.2011.06320.x"},{"key":"e_1_2_15_153_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox8090344"},{"key":"e_1_2_15_154_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010025\u201005469\u20100"},{"key":"e_1_2_15_155_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232112841"},{"key":"e_1_2_15_156_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12192\u2010021\u201001231\u20103"},{"key":"e_1_2_15_157_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms10091848"},{"key":"e_1_2_15_158_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines11041131"},{"key":"e_1_2_15_159_1","doi-asserted-by":"publisher","DOI":"10.1080\/21655979.2021.1972082"},{"key":"e_1_2_15_160_1","doi-asserted-by":"publisher","DOI":"10.1210\/endocr\/bqz006"},{"key":"e_1_2_15_161_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933\u2010022\u201001535\u20103"},{"key":"e_1_2_15_162_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11357\u2010019\u201000061\u20107"},{"key":"e_1_2_15_163_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0171479"},{"key":"e_1_2_15_164_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006\u20108993(00)03075\u20104"},{"key":"e_1_2_15_165_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells10040721"},{"key":"e_1_2_15_166_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00001.2019"},{"key":"e_1_2_15_167_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10787\u2010023\u201001167\u20103"},{"key":"e_1_2_15_168_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a006189"},{"key":"e_1_2_15_169_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.113555"},{"key":"e_1_2_15_170_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines10040742"},{"key":"e_1_2_15_171_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25235591"},{"key":"e_1_2_15_172_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.760186"},{"key":"e_1_2_15_173_1","doi-asserted-by":"publisher","DOI":"10.1002\/ddr.70051"},{"key":"e_1_2_15_174_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules20033549"},{"key":"e_1_2_15_175_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-813820-5.00018-0"},{"key":"e_1_2_15_176_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e41002"},{"key":"e_1_2_15_177_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep18798"},{"key":"e_1_2_15_178_1","doi-asserted-by":"publisher","DOI":"10.1021\/tx5002817"},{"key":"e_1_2_15_179_1","doi-asserted-by":"publisher","DOI":"10.4196\/kjpp.2014.18.1.1"},{"key":"e_1_2_15_180_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20060579"},{"key":"e_1_2_15_181_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.111750"},{"key":"e_1_2_15_182_1","doi-asserted-by":"publisher","DOI":"10.1186\/1479\u20105876\u20107\u201017"},{"key":"e_1_2_15_183_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox9090792"},{"key":"e_1_2_15_184_1","doi-asserted-by":"publisher","DOI":"10.1007\/s43188\u2010021\u201000114\u20100"},{"key":"e_1_2_15_185_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gendis.2021.06.003"},{"key":"e_1_2_15_186_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40120\u2010022\u201000338\u20108"},{"key":"e_1_2_15_187_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI11830"},{"key":"e_1_2_15_188_1","doi-asserted-by":"publisher","DOI":"10.3390\/app11188475"},{"key":"e_1_2_15_189_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgr.2014.09.002"},{"key":"e_1_2_15_190_1","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2014.42"},{"key":"e_1_2_15_191_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010022\u201020284\u20107"},{"key":"e_1_2_15_192_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2021.104480"},{"key":"e_1_2_15_193_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2018.06.126"},{"key":"e_1_2_15_194_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2003.08.013"},{"key":"e_1_2_15_195_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1333.014"},{"key":"e_1_2_15_196_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox12101883"},{"key":"e_1_2_15_197_1","doi-asserted-by":"publisher","DOI":"10.2174\/1871527313666140806144831"},{"key":"e_1_2_15_198_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms231911816"},{"key":"e_1_2_15_199_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells11081312"},{"key":"e_1_2_15_200_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.1015835"},{"key":"e_1_2_15_201_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2013.11.013"},{"key":"e_1_2_15_202_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2014.10.012"},{"key":"e_1_2_15_203_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0891\u20105849(00)00301\u20104"},{"key":"e_1_2_15_204_1","doi-asserted-by":"publisher","DOI":"10.35248\/2161\u20101459.23.13.393"},{"key":"e_1_2_15_205_1","doi-asserted-by":"publisher","DOI":"10.1186\/s42826\u2010024\u201000190\u2010x"},{"key":"e_1_2_15_206_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2021.653651"},{"key":"e_1_2_15_207_1","doi-asserted-by":"publisher","DOI":"10.3390\/plants10122751"},{"key":"e_1_2_15_208_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2024.116963"},{"key":"e_1_2_15_209_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2021.12252"},{"key":"e_1_2_15_210_1","doi-asserted-by":"publisher","DOI":"10.4239\/wjd.v13.i11.972"},{"key":"e_1_2_15_211_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.138823"},{"key":"e_1_2_15_212_1","doi-asserted-by":"publisher","DOI":"10.1042\/BST20150014"},{"key":"e_1_2_15_213_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2022.11484"},{"key":"e_1_2_15_214_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2023.105682"},{"key":"e_1_2_15_215_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphs.2024.06.003"},{"key":"e_1_2_15_216_1","doi-asserted-by":"publisher","DOI":"10.26599\/FSHW.2022.9250247"},{"key":"e_1_2_15_217_1","doi-asserted-by":"publisher","DOI":"10.31083\/j.fbl2903109"},{"key":"e_1_2_15_218_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.22763"},{"key":"e_1_2_15_219_1","doi-asserted-by":"publisher","DOI":"10.2741\/265"},{"key":"e_1_2_15_220_1","doi-asserted-by":"publisher","DOI":"10.5021\/ad.2017.29.4.508"},{"key":"e_1_2_15_221_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2017.11.003"},{"key":"e_1_2_15_222_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2025.107601"},{"key":"e_1_2_15_223_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells11101594"},{"key":"e_1_2_15_224_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.1047550"},{"key":"e_1_2_15_225_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2018.07.148"},{"key":"e_1_2_15_226_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2022.175072"},{"key":"e_1_2_15_227_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.3c08225"},{"key":"e_1_2_15_228_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.205969"},{"key":"e_1_2_15_229_1","doi-asserted-by":"publisher","DOI":"10.1002\/ddr.21170"},{"key":"e_1_2_15_230_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox14040492"},{"key":"e_1_2_15_231_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2008.10.014"},{"key":"e_1_2_15_232_1","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.31.1_supplement.46.4"},{"key":"e_1_2_15_233_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13205\u2010021\u201002738\u20103"},{"key":"e_1_2_15_234_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2019.05.027"},{"key":"e_1_2_15_235_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tifs.2020.06.002"},{"key":"e_1_2_15_236_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2019.05.004"}],"container-title":["European Journal of Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ejn.70364","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ejn.70364","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ejn.70364","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T21:55:34Z","timestamp":1782510934000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ejn.70364"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,29]]},"references-count":235,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1111\/ejn.70364"],"URL":"https:\/\/doi.org\/10.1111\/ejn.70364","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/EJN.70364\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.70364\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.70364\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.70364\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.70364\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.70364\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.70364\/v3\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.70364\/v1\/review3","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.70364\/v3\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.70364\/v1\/decision1","asserted-by":"object"}]},"ISSN":["0953-816X","1460-9568"],"issn-type":[{"value":"0953-816X","type":"print"},{"value":"1460-9568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,29]]},"assertion":[{"value":"2025-07-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70364"}}