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To date, no study has examined NOS activity in parallel with c\u2010Fos immunoreactivity (c\u2010Fos\u2010IR) following multiple doses of these compounds. The aim of the present study was to evaluate whether catalepsy and motor balance deficits resulting from specific acute doses of haloperidol (Hal), metoclopramide (MCP), and L\u2010NOARG could correlate with changes in the number of c\u2010Fos\u2010IR and nNOS\u2010positive cells, as well as NADPH\u2010diaphorase activity in the striatum. Male Swiss mice received Hal (0.1\u20131\u2009mg\/kg, ip), MCP (1\u201345\u2009mg\/kg, ip), L\u2010NOARG (15\u201345\u2009mg\/kg, ip), or saline. An increased cataleptic effect was observed in all experimental groups. All doses of Hal and the higher doses of MCP resulted in deficits in the Rota\u2010rod test, whereas L\u2010NOARG did not affect Rota\u2010rod performance. Histochemical analysis revealed increased c\u2010Fos\u2010IR in the dorsal striatum following Hal, as well as in the dorsolateral striatum after low and intermediate clinically relevant doses of MCP. Both types of D2R antagonists led to an increase in NADPH\u2010diaphorase activity in the dorsal striatum. Similarly, the higher catalepsy\u2010inducing doses of L\u2010NOARG resulted in increased NADPH\u2010diaphorase activity in the dorsal striatum; however, these same doses also reduced c\u2010Fos\u2010IR in the dorsolateral striatum and nucleus accumbens (NAc). In conclusion, all drugs acutely induced catalepsy, with motor balance preserved after L\u2010NOARG treatment. Our findings suggest that EPS side effects may be attributed to NADPH\u2010diaphorase activity in the dorsal striatum.<\/jats:p>","DOI":"10.1111\/ejn.70386","type":"journal-article","created":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T11:01:42Z","timestamp":1768302102000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Striatal Nitric Oxide Activity Better Predicts Motor Disability Than Proto\u2010Oncogenes"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1145-4350","authenticated-orcid":false,"given":"Sonia\u00a0Guerrero","family":"Prieto","sequence":"first","affiliation":[{"name":"Graduate Program in Neuroscience &amp; Cognition, Center for Mathematics, Computation and Cognition Universidade Federal do ABC  S\u00e3o Bernardo do Campo S\u00e3o Paulo 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