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In recent years, glial cell\u2010mediated neuro\u2010immune\u2010inflammatory circuits mediated by glial cells (including spinal microglia, astrocytes, and dorsal root ganglion satellite glia) have been regarded as one of the key pathological mechanisms for the occurrence and maintenance of NP. Glial cells exacerbate pain pathogenesis by driving neuroinflammation, amplifying nociceptive signaling, and modulating ion channels and pain\u2010related signaling molecules. A systematic review of glial molecular and network alterations, correlated with the typical clinical phenotype of PHN, may provide practical clues for precise stratified therapy, drug repositioning, and novel targeted interventions (such as glial modulators, neuronutrition support, and neuro\u2010immune pathway modulation). This review aims to summarize the latest progress in glial cells and neuropathic pain, with a focus on discussing its implications and suggestions for the treatment strategies of PHN.<\/jats:p>","DOI":"10.1111\/ejn.70398","type":"journal-article","created":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T09:46:02Z","timestamp":1768902362000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Glial Contributions to Neuropathic Pain: Central and Peripheral Strategies in Postherpetic Neuralgia Pathogenesis and Therapeutics"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3251-6004","authenticated-orcid":false,"given":"Lili","family":"Huang","sequence":"first","affiliation":[{"name":"Office of the GCP Institute (Pharmaceutical Laboratories) Hangzhou Third People's Hospital  Zhejiang Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiaoling","family":"Huang","sequence":"additional","affiliation":[{"name":"Office of the GCP Institute (Pharmaceutical Laboratories) Hangzhou Third People's Hospital  Zhejiang Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuyong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Hangzhou Third People's Hospital  Zhejiang Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,20]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aax6452"},{"key":"e_1_2_11_3_1","doi-asserted-by":"crossref","DOI":"10.1172\/JCI173537","article-title":"Satellite Glial GPR37L1 and Its Ligand Maresin 1 Regulate Potassium Channel Signaling and Pain Homeostasis","volume":"134","author":"Bang S.","year":"2024","journal-title":"Journal of Clinical Investigation"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.2001.81.2.871"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells12010100"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm990441x"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.17318"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI26836"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12264-023-01101-1"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-023-01681-3"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2024.05.007"},{"key":"e_1_2_11_12_1","first-page":"381","article-title":"Macrophages and Microglia in Inflammation and Neuroinflammation Underlying Different Pain States","volume":"3","author":"Chen O.","year":"2023","journal-title":"Medicina em Revista"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/1744-8069-6-19"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0736-5748(00)00084-8"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmgh.2018.05.009"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0723-07.2007"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-020-00905-7"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.10245"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.19035-0"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00045.2019"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2021.108032"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adi2167"},{"key":"e_1_2_11_23_1","first-page":"901","article-title":"Effects of Minocycline on Inflammatory Response of Trigeminaganglion Satellite Glia Cells in Rats With Trigeminal Neuralgia","volume":"18","author":"Guo Y. 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