{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T12:30:10Z","timestamp":1777984210356,"version":"3.51.4"},"reference-count":53,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T00:00:00Z","timestamp":1769990400000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J of Neuroscience"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Subjective tinnitus (ST) has been hypothesized to arise from large\u2010scale network reorganization, but the affected circuits and their symptom scaling remain unclear. In a normal\u2010hearing cohort (\n                    <jats:italic>N<\/jats:italic>\n                    \u2009=\u2009114; 57 ST, 57 matched controls), we combined resting\u2010state fMRI graph topology, ROI\u2010to\u2010ROI connectivity, voxel\u2010based morphometry (VBM), and multivariate modelling using a harmonized 50\u2010ROI parcellation from the CONN atlas, spanning 15 functional networks. Node\u2010wise analyses (covarying age, sex, education, and motion; multiple\u2010comparison control) showed selective, not global, reconfiguration: reduced integration centered on the left posterior parahippocampal gyrus (lower global efficiency and degree), increased segregation\/clustering in inferior frontal and anterior insular hubs, longer path length in parahippocampal and frontal regions, and elevated local efficiency in the right amygdala. Network\u2010based revealed hyperconnectivity in fronto\u2013salience\u2013language\u2013cerebellar circuits and hypoconnectivity across default mode and dorsal attention\/temporo\u2010parietal pathways. Symptom coupling was convergent and dissociable: Higher tinnitus severity\/duration tracked reduced integration in medial visual\/limbic regions with increased integration\/degree in right frontal\u2013temporal opercular nodes, whereas higher anxiety related to increased integration\/clustering in subcallosal, cerebellar, and occipito\u2010limbic territories alongside decreases in putamen. VBM demonstrated widespread white\u2010matter reductions (inferior frontal, temporal pole, insula, inferior temporal gyrus, and putamen) with more focal gray\u2010matter effects, and a multivariate GLM confirmed a robust omnibus group difference. These multimodal, symptom\u2010linked signatures provide strong evidence that ST reflects targeted network reorganization reduced medial temporal\/visual\u2013limbic integration accompanied by increased local specialization within salience and control hubs and yield actionable circuit markers for patient stratification and mechanism\u2010guided treatment targeting.\n                  <\/jats:p>","DOI":"10.1111\/ejn.70417","type":"journal-article","created":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T05:32:49Z","timestamp":1770096769000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Limbic\u2010Visual Disintegration and Salience\u2010Control Specialization Characterize Tinnitus Network Topology"],"prefix":"10.1111","volume":"63","author":[{"given":"Himanshu\u00a0R.","family":"Pandey","sequence":"first","affiliation":[{"name":"Centre of Bio\u2010Medical Research Sanjay Gandhi Postgraduate Institute of Medical Sciences Campus  Lucknow India"},{"name":"Academy of Scientific and Innovative Research (AcSIR)  Ghaziabad India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amit","family":"Keshri","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Sanjay Gandhi Postgraduate Institute of Medical Sciences  Lucknow India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neeraj","family":"Sinha","sequence":"additional","affiliation":[{"name":"Centre of Bio\u2010Medical Research Sanjay Gandhi Postgraduate Institute of Medical Sciences Campus  Lucknow India"},{"name":"Academy of Scientific and Innovative Research (AcSIR)  Ghaziabad India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7690-6157","authenticated-orcid":false,"given":"Uttam","family":"Kumar","sequence":"additional","affiliation":[{"name":"Centre of Bio\u2010Medical Research Sanjay Gandhi Postgraduate Institute of Medical Sciences Campus  Lucknow India"},{"name":"Academy of Scientific and Innovative Research (AcSIR)  Ghaziabad India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,2]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.0030017"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2015.12.071"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-04811-0"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physrep.2005.10.009"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2021.102691"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2202-13-3"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2017.00022"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhn003"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2020.00028"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1018466108"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.pbr.2020.12.002"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/1073858417702621"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2013.09.010"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2377-11-75"},{"key":"e_1_2_12_16_1","unstructured":"Faber L A. 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