{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T12:29:35Z","timestamp":1777984175606,"version":"3.51.4"},"reference-count":11,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T00:00:00Z","timestamp":1772928000000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["DA043572"],"award-info":[{"award-number":["DA043572"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J of Neuroscience"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The lateral preoptic area (LPO) is a functionally heterogeneous hypothalamic structure that is increasingly recognised for its role in motivated and drug\u2010seeking behaviours. Although prior studies have shown that LPO neurons exhibit diverse activity patterns during cocaine self\u2010administration, the specific contributions of glutamatergic and GABAergic populations to conditioned responses to cocaine remain unclear. In this study, we recorded the activity of LPO glutamatergic (\n                    <jats:italic>vglut2<\/jats:italic>\n                    \u2010expressing) and GABAergic (\n                    <jats:italic>vgat<\/jats:italic>\n                    \u2010expressing) neuronal subpopulations during cocaine conditioning to identify how these cell types respond to drug\u2010associated cues in awake, behaving mice.\n                  <\/jats:p>\n                  <jats:p>Our results revealed that, after cocaine conditioning, both glutamatergic and GABAergic populations showed reduced activity upon entry into the cocaine\u2010paired chamber. However, only glutamatergic neurons exhibited increased activity when mice entered the saline\u2010paired chamber. The magnitude of these activity changes was also correlated with behavioural outcomes: reduced GABAergic activity was associated with greater preference for the cocaine\u2010paired chamber, whereas stronger glutamatergic responses were associated with greater preference for the saline\u2010paired chamber.<\/jats:p>\n                  <jats:p>These findings indicate that LPO GABAergic and glutamatergic neurons exhibit distinct, cell type\u2013specific patterns during cocaine\u2010conditioned place preference. Rather than indicating opposing motivational states, the results highlight that LPO activity relates to conditioned behaviours in a cell type\u2013 and context\u2010dependent manner. By linking activity in glutamatergic and GABAergic neurons with conditioned responses, this work provides initial evidence for how LPO circuits may contribute to drug\u2010associated learning.<\/jats:p>","DOI":"10.1111\/ejn.70446","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T15:17:49Z","timestamp":1772983069000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cell Type\u2013Specific Encoding of Cocaine\u2010Conditioned Responses in the Lateral Preoptic Area"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9120-2676","authenticated-orcid":false,"given":"Jennifer\u00a0I.","family":"Mejaes","sequence":"first","affiliation":[{"name":"Department of Psychology Rutgers, The State University of New Jersey  Piscataway New Jersey USA"},{"name":"Zuckerman Mind Brain Behavior Institute Columbia University  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rithikaa","family":"Rajendran","sequence":"additional","affiliation":[{"name":"Department of Psychology Rutgers, The State University of New Jersey  Piscataway New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kamila","family":"Sayed","sequence":"additional","affiliation":[{"name":"Department of Psychology Rutgers, The State University of New Jersey  Piscataway New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pavankumar","family":"Yecham","sequence":"additional","affiliation":[{"name":"Department of Psychology Rutgers, The State University of New Jersey  Piscataway New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allison","family":"Bernstein","sequence":"additional","affiliation":[{"name":"Department of Psychology Rutgers, The State University of New Jersey  Piscataway New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4609-6787","authenticated-orcid":false,"given":"David\u00a0J.","family":"Barker","sequence":"additional","affiliation":[{"name":"Department of Psychology Rutgers, The State University of New Jersey  Piscataway New Jersey USA"},{"name":"Brain Health Institute Rutgers University  Piscataway New Jersey USA"},{"name":"Rutgers Addiction Research Center  Piscataway New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,3,8]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.10.066"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429\u2010014\u20100736\u20106"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2023.113029"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2020.173093"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.15452"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2019.01433"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.07.014"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2022.173488"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2024.1359225"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380\u2010024\u201002843\u20108"},{"key":"e_1_2_11_12_1","doi-asserted-by":"crossref","unstructured":"Nicot A. P.Yecham I.Serin D. J.Barker andL. K.Dobbs.2025.Shifted Balance Between Ventral Striatal Prodynorphin and Proenkephalin Biases Development of Cocaine Place Avoidance. bioRxiv: the preprint server for biology 2025.02.28.640871.https:\/\/doi.org\/10.1101\/2025.02.28.640871.","DOI":"10.1101\/2025.02.28.640871"}],"container-title":["European Journal of Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ejn.70446","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ejn.70446","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ejn.70446","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T20:26:58Z","timestamp":1777408018000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ejn.70446"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":11,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1111\/ejn.70446"],"URL":"https:\/\/doi.org\/10.1111\/ejn.70446","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/EJN.70446\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.70446\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.70446\/v1\/review4","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.70446\/v1\/review3","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.70446\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.70446\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.70446\/v3\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.70446\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.70446\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.70446\/v3\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EJN.70446\/v2\/decision1","asserted-by":"object"}]},"ISSN":["0953-816X","1460-9568"],"issn-type":[{"value":"0953-816X","type":"print"},{"value":"1460-9568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"2025-07-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70446"}}