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To examine this assumption, this study aims to analyze residual neurological functions during assisted robotic gait in individuals with SCI comparing blocks (gait\u2009\u00d7\u2009resting), time after SCI (acute\u2009\u00d7\u2009chronic), injury level (paraplegic\u2009\u00d7\u2009tetraplegic), and ASIA scale (ASIA C\u2009\u00d7\u2009D). The hemodynamic functions were analyzed using functional near\u2010infrared spectroscopy (fNIRS) in 23 individuals (11 acute, 12 chronic; ASIA Impairment Scale grade C: 10, D: 13; paraplegia: 15, tetraplegia: 8) while performing an assisted robotic gait task (Lokomat). Brain areas analyzed included supplementary motor area (SMA), dorsolateral prefrontal cortex (DLPFC), primary motor cortex (M1), and primary somatosensory cortex (S1). Blocks (robotic gait\u2009\u00d7\u2009resting), acute\u2009\u00d7\u2009chronic, paraplegic\u2009\u00d7\u2009tetraplegic, and ASIA C\u2009\u00d7\u2009ASIA D groups were compared. For the block comparison, there was a significant difference in SMA and M1, with higher oxyhemoglobin values in the robotic gait task compared to resting. For the comparison between groups, there was a significant difference in M1, with higher oxyhemoglobin values in the chronic group compared to the acute group. The individuals with paraplegia exhibited greater activity in M1 than those with tetraplegia during the robotic gait task. These results demonstrate the plasticity and adaptability of brain motor cortex areas even during the chronic phase after SCI. The brain motor cortex activity during a walking motor task reinforces the importance of analyzing residual neurological function after SCI.<\/jats:p>","DOI":"10.1111\/ejn.70459","type":"journal-article","created":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T11:35:26Z","timestamp":1773142526000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cortical Brain Activation During Robot\u2010Assisted Gait in Humans With Acute and Chronic Spinal Cord Injury: A Functional Near\u2010Infrared Spectroscopy Study"],"prefix":"10.1111","volume":"63","author":[{"given":"Ana\u00a0Rita\u00a0C.","family":"Donati","sequence":"first","affiliation":[{"name":"Instituto de Medicina F\u00edsica e Reabilita\u00e7\u00e3o, Hospital das Cl\u00ednicas HCFMUSP, Faculdade de Medicina Universidade de S\u00e3o Paulo  S\u00e3o Paulo S\u00e3o Paulo Brazil"},{"name":"Associa\u00e7\u00e3o de Assist\u00eancia \u00e0 Crian\u00e7a Deficiente (AACD)  S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8758-6507","authenticated-orcid":false,"given":"Daniel\u00a0Boari","family":"Coelho","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Federal University of ABC  S\u00e3o Bernardo do Campo S\u00e3o Paulo Brazil"},{"name":"Departamento de Medicina Legal, Bio\u00e9tica, Medicina do Trabalho e Medicina F\u00edsica e Reabilita\u00e7\u00e3o, Faculdade de Medicina Universidade de S\u00e3o Paulo  S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o\u00a0Ricardo","family":"Sato","sequence":"additional","affiliation":[{"name":"Center for Mathematics, Computation, and Cognition Federal University of ABC  S\u00e3o Bernardo do Campo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felipe","family":"Fregni","sequence":"additional","affiliation":[{"name":"Neuromodulation Center Spaulding Rehabilitation Hospital, Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linamara\u00a0Rizzo","family":"Battistella","sequence":"additional","affiliation":[{"name":"Instituto de Medicina F\u00edsica e Reabilita\u00e7\u00e3o, Hospital das Cl\u00ednicas HCFMUSP, Faculdade de Medicina Universidade de S\u00e3o Paulo  S\u00e3o Paulo S\u00e3o Paulo Brazil"},{"name":"Departamento de Medicina Legal, Bio\u00e9tica, Medicina do Trabalho e Medicina F\u00edsica e Reabilita\u00e7\u00e3o, Faculdade de Medicina Universidade de S\u00e3o Paulo  S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,3,10]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhh116"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1364\/BOE.4.001366"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/sc.2011.12"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gaitpost.2018.05.017"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh648"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhn083"},{"key":"e_1_2_11_8_1","volume-title":"Neuroanatomy E\u2010Book: An Illustrated Colour Text","author":"Crossman A. 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