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A common example is the suppression of responses to repetitive stimuli in sensory cortices, a phenomenon known as habituation. Within a sensory information stream, whenever a novel stimulus deviates from expectations, enhanced brain responses are observed. Mismatch negativity (MMN), the electroencephalographic waveform reflecting rule violations, is a well\u2010established biomarker for auditory deviant detection. MMN has been shown to depend on intact NMDA receptor signaling across species; nevertheless, the underlying mechanisms at the neuronal and mesoscale levels are still not fully understood. Using multi\u2010electrode array recordings in awake mice, we identified a specific biphasic spiking response in a subpopulation of primary auditory cortex (A1) neurons elicited by deviant, but not standard, sounds, wherein the second peak is abolished by acute sub\u2010anesthetic injection of ketamine, a partial non\u2010competitive NMDA receptor antagonist. We further showed that the posterior parietal cortex (PPC), a critical hub for multisensory integration and sensorimotor coordination, responds to deviant, but not repetitive, sounds, and this response is dependent upon intact NMDA receptor\u2013mediated signaling. Finally, to explore the effects of ketamine on inter\u2010cortical communication following deviance detection, we performed weighted phase lag index (wPLI) analyses during the presentation of deviant and standard sounds. This analysis showed a functional connectivity between A1 and PPC following deviant detection, which is impaired by ketamine administration. Altogether, our findings provide novel insights into the NMDA receptor\u2013dependent mechanisms underlying the processing of novelty in auditory stimuli.<\/jats:p>","DOI":"10.1111\/ejn.70471","type":"journal-article","created":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T11:45:43Z","timestamp":1775043943000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Sub\u2010Anesthetic Ketamine Administration Decreases Deviance Detection Responses at the Cellular, Population\u2010 and Mesoscale Levels"],"prefix":"10.1111","volume":"63","author":[{"given":"Maria\u00a0Isabel","family":"Carre\u00f1o\u2010Mu\u00f1oz","sequence":"first","affiliation":[{"name":"Department of Neurosciences Universit\u00e9 de Montr\u00e9al  Montreal Canada"},{"name":"CHU Sainte\u2010Justine Azrieli Research Center  Montreal 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