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We previously reported that the conditional inactivation of the\n                    <jats:italic>Mllt11<\/jats:italic>\n                    gene in the mouse superficial cortex resulted in reduced connectivity of the corpus callosum and white matter fiber tracts, resulting in reduced cortical thickness. However, the behavioral consequences of\n                    <jats:italic>Mllt11<\/jats:italic>\n                    loss are unknown. Callosal abnormalities are thought to be present in 3%\u20135% of all neurodevelopmental disorders and reduced corpus callosum volume correlates with core symptoms of autism spectrum disorder (ASD) in humans. Cortical thickness dysregulation is likewise shared among various neurodevelopmental disorders including ASD. We therefore investigated the behavioral consequences of conditional knockout of\n                    <jats:italic>Mllt11<\/jats:italic>\n                    using transgenic\n                    <jats:italic>Cux2<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>iresCre\/+<\/jats:italic>\n                    <\/jats:sup>\n                    mice. Utilizing tasks designed to reflect core ASD symptoms, we examined the behaviors of both male and female conditional knockout animals. These tests included olfaction habituation\/dishabituation, three\u2010chambered social approach, marble burying, and nestlet shredding. We found sex\u2010dependent disruptions in social preference and nestlet shredding in animals lacking\n                    <jats:italic>Mllt11<\/jats:italic>\n                    , with the female mice presenting with more disruptions than the males. Understanding the behavioral phenotype associated with genes of interest, specifically in the context of sex differences, is crucial to individualized treatment for neurodevelopmental disorders.\n                  <\/jats:p>","DOI":"10.1111\/ejn.70474","type":"journal-article","created":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T13:15:13Z","timestamp":1774617313000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Characterization of Social and Repetitive Behaviors of\n                    <i>Mllt11\/Af1q\/TcF7c<\/i>\n                    Conditional Knockout Mice"],"prefix":"10.1111","volume":"63","author":[{"given":"Emily\u00a0A.","family":"Witt","sequence":"first","affiliation":[{"name":"Department of Medical Neuroscience, Faculty of Medicine Dalhousie University, and Brain Repair Centre, Life Science Research Institute  Halifax Nova Scotia 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