{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T17:22:15Z","timestamp":1783012935338,"version":"3.54.6"},"reference-count":51,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T00:00:00Z","timestamp":1776643200000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004048","name":"Kashan University of Medical Sciences","doi-asserted-by":"publisher","award":["40262"],"award-info":[{"award-number":["40262"]}],"id":[{"id":"10.13039\/501100004048","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J of Neuroscience"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Peripheral dopamine D2 receptors (D2R) have been implicated in modulating reward\u2010related behaviors; however, their role in morphine\u2010induced conditioned place preference (CPP) remains unclear. This study evaluated whether peripheral selective D2R blockade by domperidone (DOM), with limited blood\u2013brain barrier penetration, influences morphine\u2010induced CPP in rats. Male Wistar rats were conditioned with morphine (5\u2009mg\/kg, subcutaneously [SC]) to induce CPP. DOM was administered intraperitoneally at 0.5, 1, and 2\u2009mg\/kg doses during acquisition, expression, and extinction phases. Behavioral CPP was assessed, and hippocampal D2R expression was measured via Western blot. During acquisition, all DOM doses significantly attenuated CPP, with 1\u2009mg\/kg being most effective (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). In expression, 1 and 2\u2009mg\/kg doses reduced CPP (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001), with 1\u2009mg\/kg more effective. Only 1\u2009mg\/kg facilitated extinction (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.01) and prevented reinstatement. Morphine has previously been shown to increase hippocampal D2R expression. In our experiments, DOM significantly decreased D2R expression in both expression and extinction phases. These results demonstrate that D2R antagonism by DOM can modulate morphine\u2010induced CPP and hippocampal D2R expression, highlighting a potential role of peripheral dopaminergic mechanisms in opioid reward. DOM's peripheral action and efficacy suggest therapeutic potential in opioid use disorders.\n                  <\/jats:p>","DOI":"10.1111\/ejn.70510","type":"journal-article","created":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T05:06:33Z","timestamp":1776747993000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Domperidone Modulates Hippocampal D2 Expression, Facilitates Extinction, and Attenuates Morphine\u2010Induced Conditioned Place Preference in Rats"],"prefix":"10.1111","volume":"63","author":[{"given":"Amineh\u00a0Sadat","family":"Zahiri\u2010Pour","sequence":"first","affiliation":[{"name":"Clinical Research Development Unit\u2010Matini, Kargarnejad Hospital Kashan University of Medical Sciences  Kashan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farkhondeh","family":"Razzaghi\u2010Firozjaei","sequence":"additional","affiliation":[{"name":"Clinical Research Development 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