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Recent research by our group showed the relationship between physical neglect and facial emotion recognition is mediated by inflammation. While this mediation effect was observed at the level of behaviour, examining the relationship between physical neglect, inflammation and neural activation during facial emotion recognition would help confirm brain regions impacted and support behavioural findings, but these relationships are unclear. Two hundred twelve participants (52 patients with schizophrenia and 160 healthy controls) underwent functional magnetic resonance imaging while performing an established facial emotion recognition task and a subset completed the Childhood Trauma Questionnaire and provided blood samples outside of the scanner. Inflammation was measured using a latent variable that combined basal plasma levels of interleukin\u20106, tumour necrosis factor\u2010alpha and C\u2010reactive protein. The relationships between physical neglect, inflammation and neural activation were examined using multiple regression. Neither physical neglect nor inflammation predicted altered neural response during facial emotion recognition at\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05, family\u2010wise error corrected for multiple comparisons within an anterior cingulate region of interest, across the whole brain, in the whole sample or separately in patients or controls. Future research should examine relationships between physical neglect, inflammation and brain activation in larger samples, which may have sensitivity to detect smaller effects, and use tasks that require active recognition of emotions, in addition to passive viewing of faces, which might be associated with additional neural responses.\n                  <\/jats:p>","DOI":"10.1111\/ejn.70518","type":"journal-article","created":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T04:45:22Z","timestamp":1777005922000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Examining the Relationship Between Physical Neglect, Inflammation and Anterior Cingulate Activation During Facial Emotion Recognition in Patients With Schizophrenia and Healthy Controls: A Functional Magnetic Resonance Imaging Study"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3013-4088","authenticated-orcid":false,"given":"David","family":"Mothersill","sequence":"first","affiliation":[{"name":"Academic Unit of Neurology, School of Medicine Trinity College Dublin  Dublin Ireland"},{"name":"School of Psychology University of Galway  Galway Ireland"},{"name":"Centre for Neuroimaging, Cognition, and Genomics (NICOG) University of Galway  Galway Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sinead","family":"King","sequence":"additional","affiliation":[{"name":"School of Psychology University of Galway  Galway Ireland"},{"name":"Centre for Neuroimaging, Cognition, and Genomics (NICOG) University of Galway  Galway Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Corley","sequence":"additional","affiliation":[{"name":"School of Psychology University of Galway  Galway Ireland"},{"name":"Centre for Neuroimaging, Cognition, and Genomics (NICOG) University of Galway  Galway Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saahithh\u00a0Redddi","family":"Patlola","sequence":"additional","affiliation":[{"name":"Centre for Neuroimaging, Cognition, and Genomics (NICOG) University of Galway  Galway Ireland"},{"name":"Pharmacology &amp; 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