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Resting\u2010state electroencephalography studies have revealed abnormal brain activity in chronic pain conditions, with anxiety and symptom duration potentially exacerbating these alterations. This study applied multivariate pattern analysis to differentiate intertrial resting\u2010state electroencephalography signals between fibromyalgia patients and healthy controls across frequency bands associated with pain processing, incorporating state and trait anxiety scores. It also examined differences between patients with short\u2010 and long\u2010duration symptoms and identified the most relevant scalp regions contributing to the models. Fifty\u2010one female participants (25 fibromyalgia patients, 26 controls; aged 35\u201365) were included. Patients were classified into short\u2010term (12) and long\u2010term (13) groups. Normalized power spectral density values were extracted from electroencephalography data and used to train machine learning classifiers, with Haufe\u2010transformed weights computed to determine key scalp contributions. The models distinguished patients from controls with area under the curve values exceeding 0.75 across all frequency bands, reaching 0.99 in beta and gamma bands when anxiety was included. Symptom duration was also a relevant factor, as the model differentiated short\u2010 from long\u2010term fibromyalgia patients with area under the curve values up to 0.96 in beta and gamma bands. Alterations in theta power within frontal and parietal regions, along with frequency\u2010specific contributions, highlight disrupted pain processing in fibromyalgia and suggest cumulative effects of prolonged symptom duration. Future resting\u2010state studies leveraging multivariate pattern analysis may support the development of potential biomarkers to improve diagnosis and guide treatment strategies in clinical settings.<\/jats:p>","DOI":"10.1111\/ejn.70521","type":"journal-article","created":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T02:50:43Z","timestamp":1777344643000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Multivariate Pattern Analysis Identifies Potential Intertrial Resting\u2010State EEG Biomarkers in Fibromyalgia"],"prefix":"10.1111","volume":"63","author":[{"given":"Dino","family":"Soldic","sequence":"first","affiliation":[{"name":"Department of Psychology, Faculty of Health Sciences Rey Juan Carlos University  Madrid Spain"},{"name":"Research group in Cognitive Neuroscience, Pain and Rehabilitation (NECODOR) Rey Juan Carlos University  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0578-2825","authenticated-orcid":false,"given":"Mar\u00eda\u00a0Carmen","family":"Mart\u00edn\u2010Buro","sequence":"additional","affiliation":[{"name":"Department of Psychology, Faculty of Health Sciences Rey Juan Carlos University  Madrid Spain"},{"name":"Research group in Cognitive Neuroscience, Pain and Rehabilitation (NECODOR) Rey Juan Carlos University  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2960-3871","authenticated-orcid":false,"given":"David","family":"L\u00f3pez\u2010Garc\u00eda","sequence":"additional","affiliation":[{"name":"Mind, Brain and Behavior Research Center University of Granada  Granada Andaluc\u00eda Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana\u00a0Bel\u00e9n","family":"del Pino","sequence":"additional","affiliation":[{"name":"Department of Psychology, Faculty of Health Sciences Rey Juan Carlos University  Madrid Spain"},{"name":"Research group in Cognitive Neuroscience, Pain and Rehabilitation (NECODOR) Rey Juan Carlos University  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Fernandes\u2010Magalhaes","sequence":"additional","affiliation":[{"name":"Department of Psychology, Faculty of Health Sciences Rey Juan Carlos University  Madrid Spain"},{"name":"Research group in Cognitive Neuroscience, Pain and Rehabilitation (NECODOR) Rey Juan Carlos University  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Ferrera","sequence":"additional","affiliation":[{"name":"Department of Psychology, Faculty of Health Sciences Rey Juan Carlos University  Madrid Spain"},{"name":"Research group in Cognitive Neuroscience, Pain and Rehabilitation (NECODOR) Rey Juan Carlos University  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Pel\u00e1ez","sequence":"additional","affiliation":[{"name":"Department of Psychology, Faculty of Health Sciences Rey Juan Carlos University  Madrid Spain"},{"name":"Research group in Cognitive Neuroscience, Pain and Rehabilitation (NECODOR) Rey Juan Carlos University  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Carreti\u00e9","sequence":"additional","affiliation":[{"name":"Faculty of Psychology Autonomous University of Madrid  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Mercado","sequence":"additional","affiliation":[{"name":"Department of Psychology, Faculty of Health Sciences Rey Juan Carlos University  Madrid Spain"},{"name":"Research group in Cognitive Neuroscience, Pain and Rehabilitation (NECODOR) Rey Juan Carlos University  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,27]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11517\u2010023\u201002843\u2010w"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2023.1233979"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.2340\/16501977\u20102036"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2541\u201004.2004"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4123\u201007.2008"},{"issue":"4","key":"e_1_2_11_7_1","first-page":"767","article-title":"Quantitative Cerebral MR in Rheumatoid Arthritis","volume":"16","author":"Bekkelund S. 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