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The present study investigated how adults with acquired SSD process a complex amplitude\u2010modulated speech\u2010derived vibrotactile stimulus compared to simple periodic vibration, and how these responses differ from normal\u2010hearing (NH) controls. Twenty adults with acquired SSD and 20 age\u2010 and sex\u2010matched NH controls underwent functional magnetic resonance imaging (fMRI) during vibrotactile stimulation using a simple periodic vibration (125\u2009Hz) and speech\u2010derived vibrotactile stimulus. Behavioral performance (hit rate, reaction time) was measured. Region\u2010of\u2010interest analyses quantified activation in primary auditory cortex (PAC) and primary somatosensory cortex (S1). Additional analyses assessed differences in left versus right SSD and correlations between neural measures and clinical variables. Both groups responded faster to 125\u2009Hz than vibrotactile speech stimuli (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.03). Compared with NH controls, adults with SSD showed widespread activation of bilateral middle cingulate gyrus and the frontal operculum when processing the speech\u2010derived vibrotactile stimulus. Region\u2010of\u2010interest analyses revealed reduced stimulus selectivity in primary somatosensory cortex in SSD compared to NH, together with increased recruitment of the inferior frontal gyrus during speech\u2010derived vibrotactile stimulation. Furthermore, left\u2010hemisphere dominance was found in primary auditory cortex for both left and right SSD during both stimuli conditions. Exploratory correlation analysis revealed associations between right inferior frontal gyrus activation and sound localization scores at 3\u2009months after treatment with cochlear implant (\n                    <jats:italic>r<\/jats:italic>\n                    \u2009=\u2009\u22120.59,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.026). Speech\u2010derived vibrotactile stimulation was associated with activation of auditory and cognitive control networks in individuals with SSD, including the bilateral middle cingulate cortex. This pattern may indicate increased attentional demands when processing temporally complex vibrotactile signals. While the present findings are correlational and exploratory, they provide a basis for future studies investigating neuronal plasticity following hearing loss.\n                  <\/jats:p>","DOI":"10.1111\/ejn.70544","type":"journal-article","created":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T05:48:51Z","timestamp":1779515331000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Speech\u2010Like Vibrotactile Stimulation Is Associated With Enhanced Cortical Activations in Single\u2010Sided Deafness: An fMRI Study"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0227-8255","authenticated-orcid":false,"given":"Ghislain","family":"Sofack","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology \u2013 Head and Neck Surgery Medical Center\u2013University of Freiburg  Freiburg Germany"},{"name":"Department of Nuclear Medicine Medical Center\u2013University 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