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This study examined whether auditory stimuli affect the pupil light reflex (PLR), a parasympathetically driven response to light, in autistic and non\u2010autistic children. Pupillometry was used to measure responses to visual\u2010only (V), auditory\u2010only (A), and audiovisual (AV) stimuli in 72 children aged 8\u201314\u2009years (34 non\u2010autistic, 38 autistic). We hypothesized that auditory input would attenuate pupil constriction in non\u2010autistic children in the AV condition and that this cross\u2010modal modulation might differ in autism, reflecting altered sensory\u2010autonomic functioning. Across groups, results revealed a consistent pattern: auditory stimuli elicited pupil dilation, visual stimuli evoked constriction and simultaneous AV stimuli led to attenuated constriction relative to visual\u2010only trials. This attenuation lends support to prior findings of multisensory attenuation of the PLR. Time\u2010binned analysis revealed a group effect during the 500\u20131000\u2009ms post\u2010stimulus window: autistic children showed significantly more positive baseline\u2010corrected pupil responses across conditions (i.e., less constriction in V\/AV and greater dilation in A), suggesting group differences in the dynamic trajectory of the pupil response. Contrary to expectations, autistic and non\u2010autistic children did not differ significantly on peak constriction or constriction latency within visual conditions. Offering insight into how autistic individuals integrate sensory information and regulate arousal, these findings support the presence of cross\u2010modal modulation of the PLR and suggest that auditory signals influence early\u2010stage visual\u2010autonomic processing similarly across groups.<\/jats:p>","DOI":"10.1111\/ejn.70578","type":"journal-article","created":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T08:39:52Z","timestamp":1780994392000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Multisensory Attenuation of the Pupil Light Response in Autistic and Non\u2010Autistic Children"],"prefix":"10.1111","volume":"63","author":[{"given":"Chloe","family":"Brittenham","sequence":"first","affiliation":[{"name":"Cognitive Neurophysiology Laboratory, Department of Pediatrics Albert Einstein College of Medicine  Bronx New York USA"},{"name":"Department of Pediatrics Albert Einstein College of Medicine  Bronx New York USA"},{"name":"Department of Neuroscience Albert Einstein College of Medicine  Bronx New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theo","family":"Vanneau","sequence":"additional","affiliation":[{"name":"Cognitive Neurophysiology Laboratory, Department of Pediatrics Albert Einstein College of Medicine  Bronx New York USA"},{"name":"Department of Pediatrics Albert Einstein College of Medicine  Bronx New York USA"},{"name":"Department of Neuroscience Albert Einstein College of Medicine  Bronx New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0094-4015","authenticated-orcid":false,"given":"Sophie","family":"Molholm","sequence":"additional","affiliation":[{"name":"Cognitive Neurophysiology Laboratory, Department of Pediatrics Albert Einstein College of Medicine  Bronx New York USA"},{"name":"Department of Pediatrics Albert Einstein College of Medicine  Bronx New York USA"},{"name":"Department of Neuroscience Albert Einstein College of Medicine  Bronx New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,9]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/dev.20352"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.28.061604.135709"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13229-025-00678-w"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpsc.2021.04.010"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.13795"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2017.11.008"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpp.13179"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhs109"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10803-014-2212-9"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.5014\/ajot.2012.004242"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.105287.3"},{"key":"e_1_2_12_14_1","unstructured":"Constantino J. 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