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Although neurorrhaphy is the gold\u2010standard treatment, recovery is often incomplete. The heterologous fibrin biopolymer (HFB), a nonhuman\u2010derived and biocompatible sealant, has shown regenerative potential in neural tissues, but its effects on the spinal cord microenvironment after peripheral nerve injury remain unclear. This study evaluated the chronic regenerative effects of HFB combined with neurorrhaphy after sciatic neurotmesis in rats. Forty adult male Wistar rats were divided into four groups: control, denervated, neurorrhaphy, and neurorrhaphy\u2009+\u2009HFB. After 120\u2009days, the spinal cord, sciatic nerve, and soleus muscle were analyzed. Neurorrhaphy\u2009+\u2009HFB had more retrograded label neurons than neurorrhaphy, whereas 3D reconstruction suggests reduced neuronal dispersion compared with neurorrhaphy. HFB also positively modulated glial cells, while improving sciatic nerve integrity, with NF200, S100, and G ratio indicating improved axonal regeneration. 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