{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T10:08:17Z","timestamp":1792490897188,"version":"4.5.0"},"reference-count":78,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T00:00:00Z","timestamp":1784851200000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J of Neuroscience"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Autism spectrum disorder (ASD) is a highly heritable neurodevelopmental condition with a well\u2010characterised genetic architecture, yet how ASD\u2010associated genes map onto discrete brain regions remains poorly understood. This study applied a recently validated analysis pipeline (ATLANTE) to discover regions of the human brain enriched for high expression of 234 high\u2010confidence ASD\u2010associated genes. Eleven discrete brain regions were identified, spanning cortical, limbic and cerebellar systems including the anterior orbitofrontal gyrus, cerebellar cortex, flocculonodular lobe, vermis, posterior cingulate cortex, temporo\u2010occipital transitional zone, hippocampal subfields CA1 and CA3, postcentral gyrus, occipital cortex and perirhinal gyrus. Notably, the anterior orbitofrontal gyrus exhibited significant enrichment for syndromic ASD genes, suggesting a core role in the neuropsychiatric features of syndromic presentations. Network and community clustering analyses revealed three major gene communities corresponding to distinct biological processes: synaptic dysfunction in limbic regions, histone modification in cerebellar regions and axonal ion channel regulation in cortical regions. Nodal analysis identified eight high\u2010priority genes with broad relevance across multiple brain regions, including\n                    <jats:italic>NR3C2<\/jats:italic>\n                    ,\n                    <jats:italic>GABRB2<\/jats:italic>\n                    and\n                    <jats:italic>NBEA<\/jats:italic>\n                    . These findings provide a refined neuroanatomical framework for ASD pathophysiology, identify understudied brain regional targets and imply that ASD\u2010associated genes exert primary effects in specific brain regions.\n                  <\/jats:p>","DOI":"10.1111\/ejn.70638","type":"journal-article","created":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T04:32:07Z","timestamp":1784953927000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Autism Spectrum Disorder\u2013Associated Genes Enrich in Discrete Cortical, Limbic and Cerebellar Brain Regions"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3357-5700","authenticated-orcid":false,"given":"G. 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