{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T10:31:28Z","timestamp":1787567488663,"version":"build-2736575974"},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T00:00:00Z","timestamp":1785801600000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2024\/04859\u20100"],"award-info":[{"award-number":["2024\/04859\u20100"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019694","name":"Universidade Federal do ABC","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019694","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["306638\/2023\u20101"],"award-info":[{"award-number":["306638\/2023\u20101"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J of Neuroscience"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Freezing of gait (FoG) is frequently triggered during gait initiation, a transition that depends on anticipatory postural adjustments (APAs). However, the neuroanatomical substrates linking brain morphometry to APA control during step initiation in FoG remain unclear. We investigated whether subcortical volumes and cortical thickness in motor\u2013cognitive regions relate to APA features and clinical severity. Forty\u2010four right\u2010handed individuals with midstage PD (26 PD\u2009+\u2009FoG; 18 PD\u2009\u2212\u2009FoG) performed step initiation. FreeSurfer\u2010derived regional volumes and cortical thickness were extracted. Associations between morphometry and APA metrics were tested across all participants and within groups. Group differences were tested using the Mann\u2013Whitney\n                    <jats:italic>U<\/jats:italic>\n                    tests, and partial Spearman correlations examined morphometry\u2013clinical and morphometry\u2013APA associations, controlling for UPDRS\u2010III and daily levodopa dose. Compared with PD without FoG, the PD\u2009+\u2009FoG group showed higher UPDRS\u2010III scores and levodopa doses, lower APA mediolateral amplitudes, and larger amygdala volumes. Across all participants, longer APA duration was associated with smaller putamen, thalamus, and dorsolateral prefrontal cortex volumes, whereas greater APA mediolateral amplitude was associated with lower frontopolar cortical thickness. In PD\u2009+\u2009FoG, freezing severity and APA features were associated with distinct morphometric patterns across the basal ganglia, thalamus, prefrontal, cingulate, SMA, and insular regions. These findings suggest that gait initiation impairment in PD reflects distributed morphometric alterations rather than a single regional substrate. APA measures may provide mechanistically relevant biomechanical markers for identifying neural systems involved in FoG.\n                  <\/jats:p>","DOI":"10.1111\/ejn.70647","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T02:47:41Z","timestamp":1785898061000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Brain Morphometry Fingerprints are Associated with Gait Initiation Deficits in Parkinson\u2019s Disease and Freezing of Gait"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0402-2648","authenticated-orcid":false,"given":"Luana","family":"dos Santos de Oliveira","sequence":"first","affiliation":[{"name":"Center for Mathematics, Computation and Cognition Federal University of ABC  S\u00e3o Bernardo do Campo 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Lima\u2010Pardini","sequence":"additional","affiliation":[{"name":"Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3678-8456","authenticated-orcid":false,"given":"Fabio Augusto","family":"Barbieri","sequence":"additional","affiliation":[{"name":"S\u00e3o Paulo State University (UNESP) School of Sciences, Department of Physical Education, Human Movement Research Laboratory (MOVI\u2010LAB)  Bauru SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8758-6507","authenticated-orcid":false,"given":"Daniel Boari","family":"Coelho","sequence":"additional","affiliation":[{"name":"Center for Mathematics, Computation and Cognition Federal University of ABC  S\u00e3o Bernardo do Campo Brazil"},{"name":"Biomedical Engineering Federal University of ABC  S\u00e3o Bernardo do Campo SP 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