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Electrophysiological recordings showed that chronic noise exposure is associated with increased intrinsic excitability of serotonergic (5\u2010HT) neurons in the dorsal raphe nucleus (DRN), characterized by a depolarized resting membrane potential, increased spontaneous firing frequency, reduced rheobase, and elevated input resistance. In addition, chronic noise exposure was associated with enhanced excitatory synaptic input onto DRN 5\u2010HTergic neurons, as reflected by an increase in the frequency, but not the amplitude, of both spontaneous and miniature excitatory postsynaptic currents. In contrast, neither intrinsic excitability nor excitatory synaptic transmission of local DRN GABAergic neurons was significantly altered. Furthermore, pharmacological blockade of AMPA and NMDA receptors indicated that the increased excitability of DRN 5\u2010HTergic neurons cannot be fully explained by enhanced excitatory synaptic input alone, suggesting a potential contribution of intrinsic membrane mechanisms. Together, these findings provide correlational evidence that chronic noise exposure is associated with functional alterations in DRN 5\u2010HTergic neurons and may represent a potential neural correlate of noise\u2010related anxiety\u2010like behavior.<\/jats:p>","DOI":"10.1111\/ejn.70653","type":"journal-article","created":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T11:14:29Z","timestamp":1787915669000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Chronic Noise Exposure Induces Anxiety\u2010Like Behavior and Enhances the Excitability of Dorsal Raphe Serotonergic Neurons in Mice"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-5260-519X","authenticated-orcid":false,"given":"Quan","family":"Yuan","sequence":"first","affiliation":[{"name":"School of Life Sciences and Medical Engineering Anhui University  Hefei China"},{"name":"Key Laboratory of Human Microenvironment 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