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Here, we apply high\u2010resolution, voxel\u2010based, whole\u2010brain metabolic mapping using the [\n                    <jats:sup>14<\/jats:sup>\n                    C]\u20102\u2010deoxyglucose autoradiographic method in adult, female mice to assess functional brain reorganization in a subacute stage (1\u2009week after SCI). Right moderate contusive injury at the cervical 5 level was confirmed by glial fibrillary acidic protein (GFAP) immunohistochemical staining. SCI compared to sham\u2010lesioned animals showed significant motor deficits (grip strength and rotarod) alongside decreases in glucose uptake in sensorimotor regions of the cortex, basal ganglia, and thalamus. In contrast, regions in the limbic system (the amygdala, accumbens nucleus, lateral septum, and hippocampus) and in the cerebellum demonstrated increases in glucose uptake in SCI animals. Most of these effects were noted bilaterally, suggesting functional reorganization involving ascending and descending neural pathways in both hemispheres. In addition, functional metabolic connectivity between the ventral posterolateral thalamic nucleus and primary somatosensory cortex was bilaterally decreased. The current preliminary findings underscore the broadness of brain reorganization in the subacute stage following a unilateral contusive\u2010type SCI. Functional whole\u2010brain metabolic mapping provides a roadmap for future targeted studies examining neuroplastic markers to evaluate new therapeutic strategies.\n                  <\/jats:p>","DOI":"10.1111\/ejn.70661","type":"journal-article","created":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T08:29:28Z","timestamp":1787905768000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Changes in Cerebral Glucose Metabolism at Rest Following Hemicontusive Cervical Spinal Cord Injury in Mice: A Whole\u2010Brain Autoradiographic Study"],"prefix":"10.1111","volume":"64","author":[{"given":"Zhuo","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences University of Southern California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camelia A.","family":"Danilov","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery University of Southern California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dilan","family":"Setiya","sequence":"additional","affiliation":[{"name":"Alfred E. Mann School of Pharmacy and Pharmaceutical Sciences University of Southern California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4297-8280","authenticated-orcid":false,"given":"Daniel P.","family":"Holschneider","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences University of Southern California  Los Angeles California USA"},{"name":"Department of Neurology University of Southern California  Los Angeles California USA"},{"name":"Department of Biomedical Engineering University of Southern California  Los Angeles California USA"},{"name":"Graduate Program in Neuroscience University of Southern California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,28]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2009.09.028"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.1998.00454.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.07-12-04159.1987"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(90)90179-F"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(89)90981-5"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903350402"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25042224"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2025.1568222"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijnm.ijnm_133_21"},{"key":"e_1_2_9_11_1","doi-asserted-by":"crossref","unstructured":"Clasca F..2023. 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