{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T18:44:29Z","timestamp":1792176269069,"version":"4.4.0"},"reference-count":55,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:00:00Z","timestamp":1787788800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:00:00Z","timestamp":1787788800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J of Neuroscience"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The underlying neural mechanisms associated with falls in Parkinson's disease (PD) are not fully understood. We aimed to identify measures of resting\u2010state functional connectivity (rs\u2010FC) among cortical and subcortical regions that best discriminate fallers from nonfallers in people with PD. People with mild\u2010to\u2010moderate PD were classified as fallers (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200923) or nonfallers (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200935) based on falls in the previous 12\u2009months. Following resting\u2010state functional magnetic resonance imaging, measures of rs\u2010FC were obtained for multiple subcortical and cortical regions of interest (ROIs) associated with the control of gait and balance. To investigate the combinations of (up to three) measures that best discriminate fallers from nonfallers, we applied logistic regression employing a \u2018best subsets selection strategy\u2019 with a five\u2010fold cross validation and calculated the area under the curve (AUC). The most consistently selected measures in the top 10 ranked models were the rs\u2010FC between the following ROIs: left dorsolateral prefrontal cortex (DLPFC)\u2013hypothalamus, and somatosensory cortex\u2013globus pallidus internus. Relative to nonfallers, fallers had reduced rs\u2010FC between these two ROIs pairs (Cohen's\n                    <jats:italic>d<\/jats:italic>\n                    \u2009=\u20090.918 and 0.765, respectively). The model combining these pairs with the rs\u2010FC between the right DLPFC and the thalamus achieved an AUC of 0.87 (95% CI: 0.77\u20130.97). The rs\u2010FC between the left DLPFC and the hypothalamus, and between the somatosensory cortex and the globus pallidus internus, discriminate fallers from nonfallers in PD, representing potential targets for interventions. Connectivity deficits may limit the ability of fallers in processing information in a timely and accurate manner.\n                  <\/jats:p>","DOI":"10.1111\/ejn.70666","type":"journal-article","created":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T06:51:30Z","timestamp":1787899890000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Resting State Functional Connectivity Among Cortical and Subcortical Grey Matter Structures Can Distinguish Fallers in Parkinson's Disease"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7128-9452","authenticated-orcid":false,"given":"Rodrigo","family":"Vitorio","sequence":"first","affiliation":[{"name":"School of Sport, Exercise and Rehabilitation, Faculty of Health and Wellbeing Northumbria University  Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1331-9611","authenticated-orcid":false,"given":"Korey P.","family":"Wylie","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Colorado Anschutz Medical Campus  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2258-1689","authenticated-orcid":false,"given":"Justin W.","family":"Andrushko","sequence":"additional","affiliation":[{"name":"School of Sport, Exercise and Rehabilitation, Faculty of Health and Wellbeing Northumbria University  Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,27]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/906274"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/s23104651"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2017.04.070"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1089\/brain.2015.0347"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1011007"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.01.021"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhw157"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.27195"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.15304"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.162.7.1256"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2019.00764"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.28895"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2017.02.073"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2006.06.027"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/mdc3.12831"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2014.03.034"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2015.08.002"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1117\/1.NPh.4.4.041403"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781118548387"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.55.3.181"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2002.1132"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.09.015"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1361-8415(01)00036-6"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhq096"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.12.060"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a009621"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v088.i02"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-015-7650-6"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2005.11.020"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glaa174"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1177\/1545968320924430"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2019.04.007"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.02.046"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.13238"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci13111552"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2007.09.027"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gaitpost.2022.07.003"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-015-7865-6"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.5114\/ninp.2013.38222"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.11.046"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2002.1161"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.1089\/brain.2020.0975"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2019.01425"},{"key":"e_1_2_13_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.10062"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2004.07.051"},{"key":"e_1_2_13_47_1","doi-asserted-by":"publisher","DOI":"10.14802\/jmd.16062"},{"key":"e_1_2_13_48_1","doi-asserted-by":"publisher","DOI":"10.3390\/s23104866"},{"key":"e_1_2_13_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2022.105235"},{"key":"e_1_2_13_50_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2024.1361063"},{"key":"e_1_2_13_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2008.10.055"},{"key":"e_1_2_13_52_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2021.633872"},{"key":"e_1_2_13_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.15899"},{"key":"e_1_2_13_54_1","unstructured":"Wylie K. P. B. M.Kluger L. D.Medina et\u00a0al.2026. \u201cParkinson's Disease Functional Connectivity and Cognition.\u201d OpenNeuro.https:\/\/doi.org\/10.18112\/openneuro.ds004392.v1.0.2."},{"key":"e_1_2_13_55_1","doi-asserted-by":"publisher","DOI":"10.1109\/42.906424"},{"key":"e_1_2_13_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1983.tb09716.x"}],"container-title":["European Journal of Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ejn.70666","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ejn.70666","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ejn.70666","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T17:48:20Z","timestamp":1792172900000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ejn.70666"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,27]]},"references-count":55,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1111\/ejn.70666"],"URL":"https:\/\/doi.org\/10.1111\/ejn.70666","archive":["Portico"],"relation":{},"ISSN":["0953-816X","1460-9568"],"issn-type":[{"value":"0953-816X","type":"print"},{"value":"1460-9568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,27]]},"assertion":[{"value":"2026-03-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70666"}}