{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T04:38:39Z","timestamp":1792643919959,"version":"4.5.0"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:00:00Z","timestamp":1788825600000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["88887.822239\/2023\u201000"],"award-info":[{"award-number":["88887.822239\/2023\u201000"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["Project 310,618\/2021\u20105"],"award-info":[{"award-number":["Project 310,618\/2021\u20105"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J of Neuroscience"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Trigeminal neuralgia has been associated with microstructural alterations of the trigeminal nerve, particularly at the root entry zone, but region\u2010specific reference data stratified by sex in healthy individuals are lacking. This study aimed to characterise the regional organisation of the trigeminal nerve using diffusion tensor imaging (DTI) metrics and volumetry in healthy young adults, describing regional heterogeneity, lateral asymmetry and sex effects. T1\u2010weighted and diffusion\u2010weighted images from 300 Human Connectome Project participants (150 women, 150 men; 22\u201335\u2009years) were used to bilaterally segment four regions of the trigeminal nerve. For each region of interest, we derived absolute and relative volumes, fractional anisotropy, mean diffusivity, axial diffusivity and radial diffusivity, computed asymmetry indices and coefficients of variation, and applied\n                    <jats:italic>t<\/jats:italic>\n                    \u2010tests, MANOVA and effect sizes to assess regional, lateral and sex\u2010related differences. We observed a pronounced regional gradient in fractional anisotropy, with highest values at the root entry zone and a progressive decrease towards Meckel's cave. Lateral asymmetries were generally small, and sex systematically influenced diffusion metrics and volumes in specific regions of interest, while preserving the same spatial pattern along the nerve. In healthy young adults, the trigeminal nerve exhibits a marked regional gradient in fractional anisotropy, accompanied by modest physiological lateral asymmetry and consistent sex\u2010related differences. These findings establish region\u2010 and sex\u2010specific reference ranges for diffusion metrics and volumes of the trigeminal nerve, providing a quantitative framework to distinguish expected variability from disease\u2010compatible alterations in future studies.\n                  <\/jats:p>","DOI":"10.1111\/ejn.70668","type":"journal-article","created":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T09:07:09Z","timestamp":1788858429000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Regional Organisation and Sex\u2010Related Differences in Trigeminal Nerve DTI Metrics in Healthy Young Adults"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1775-3012","authenticated-orcid":false,"given":"Eduardo Rocha","family":"Arruda","sequence":"first","affiliation":[{"name":"Departamento de Neuroci\u00eancias e Ci\u00eancias do Comportamento, Faculdade de Medicina de Ribeir\u00e3o Preto Universidade de S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4855-5668","authenticated-orcid":false,"given":"Hohana G.","family":"Konell","sequence":"additional","affiliation":[{"name":"A.C. Camargo Cancer Center (CIPE)  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos E.","family":"Garrido Salmon","sequence":"additional","affiliation":[{"name":"Departmento de F\u00edsica, Faculdade de Filosofia Ci\u00eancias e Letras de Ribeir\u00e3o Preto Universidade de S\u00e3o Paulo  S\u00e3o Paulo Brazil"},{"name":"Departamento de Imagens M\u00e9dicas, Hematolog\u00eda e Oncolog\u00eda Cl\u00ednica, Faculdade de Medicina de Ribeir\u00e3o Preto Universidade de S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,8]]},"reference":[{"key":"e_1_2_15_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nurt.2007.05.011"},{"key":"e_1_2_15_3_1","article-title":"High Spatial Resolution Nerve\u2010Specific DTI Protocol Outperforms Whole\u2010Brain DTI Protocol for Imaging the Trigeminal Nerve in Healthy Individuals","volume":"33","author":"Danyluk H.","year":"2020","journal-title":"NMR in Biomedicine"},{"key":"e_1_2_15_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-023-06923-5"},{"key":"e_1_2_15_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000000156"},{"key":"e_1_2_15_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2013.08.029"},{"key":"e_1_2_15_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnana.2016.00095"},{"key":"e_1_2_15_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s43055-023-01102-0"},{"key":"e_1_2_15_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.04.127"},{"key":"e_1_2_15_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102417738202"},{"key":"e_1_2_15_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2011.06.029"},{"key":"e_1_2_15_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00701-019-03913-5"},{"key":"e_1_2_15_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00701-013-1970-z"},{"key":"e_1_2_15_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2012.11.027"},{"key":"e_1_2_15_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102414566819"},{"key":"e_1_2_15_16_1","volume-title":"Imaging of the Brain","author":"Naidich T. 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