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More specifically, in the present study, we hypothesized that autistic individuals are less likely to mobilize motor preparatory processes when given reason to anticipate an imperative cue. In a preregistered experiment, we asked participants to respond as quickly as possible to target sounds embedded in a regular periodic sequence of tones, and informed them that the three distinct auditory tones in the sequence signal different probabilities of a target on the next beat. We found that a group of autistic participants showed significantly less benefit of cues signaling high target probability on target response time than an IQ\u2010 and language\u2010matched control group of non\u2010autistic participants. In concurrent electroencephalography (EEG) recordings, the autistic group also showed a reduced effect of high probability cues on the late CNV, a motor preparatory ramping potential. Group differences in anticipatory desynchronization of motor\u2010related mu and beta oscillations were less straightforward\u2014rather than showing broadly weaker predictive desynchronization, the autistic group showed reduced desynchronization specifically following medium probability cues. We also found evidence of a group difference in neural entrainment to the 1\u2009Hz periodic sequence: the autistic group showed shallower ramping potentials anticipating the next event across all cue types, and reduced phase entrainment at posterior electrodes. Our results focus attention on reduced spontaneous predictive motor preparation as a possible sensorimotor contribution to autism's more visible manifestations.<\/jats:p>","DOI":"10.1111\/ejn.70673","type":"journal-article","created":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T05:56:00Z","timestamp":1789106160000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Reduced Motor Preparation and Altered EEG Signatures of Prediction in Autistic Adults"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-3463-4244","authenticated-orcid":false,"given":"Soroush","family":"Bagheri","sequence":"first","affiliation":[{"name":"Department of Psychology, Neuroscience and Behavior, Faculty of Science McMaster University  Hamilton Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2727-287X","authenticated-orcid":false,"given":"Annie","family":"Cardinaux","sequence":"additional","affiliation":[{"name":"McGovern Institute for Brain Research Massachusetts Institute of Technology  Cambridge Massachusetts USA"},{"name":"Hock E. 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