{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T02:56:18Z","timestamp":1790564178066,"version":"4.1.0"},"reference-count":77,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["PJT\u2010148648"],"award-info":[{"award-number":["PJT\u2010148648"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["419286"],"award-info":[{"award-number":["419286"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J of Neuroscience"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Feedback controls play important roles in biological systems, from the cellular level to systemic levels. Positive and negative feedback are two major feedback mechanisms. In this review, I will mainly investigate the positive feedback system involved in pain transmission, modulation and plasticity. At the level of the spinal cord, descending facilitation from different regions of supraspinal structures exert facilitatory effects on spinal nociceptive transmission. At the level of the cortex, positive feedback at synaptic and cellular levels contribute to long\u2010term potentiation (LTP) of synaptic transmission. Several key signalling pathways for positive feedback will be discussed, in particular, NMDA receptor\u2010adenylyl cyclase subtype 1 (AC1)\u2013dependent signalling pathways. Finally, at both physiological and pathological points of view, the importance of positive feedback in chronic pain will be discussed.<\/jats:p>","DOI":"10.1111\/ejn.70679","type":"journal-article","created":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T13:42:38Z","timestamp":1789479758000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Positive Feedback Mechanisms in Pain Modulation and Chronic Pain"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9062-3241","authenticated-orcid":false,"given":"Min","family":"Zhuo","sequence":"first","affiliation":[{"name":"Center for Translational Pain and Emotion Jinhua Academy of Zhejiang Chinese Medical University  Jinhua China"},{"name":"Department of Physiology, Faculty of Medicine University of Toronto  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,15]]},"reference":[{"key":"e_1_2_19_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40122-017-0073-6"},{"key":"e_1_2_19_3_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ne.07.030184.001521"},{"key":"e_1_2_19_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-37878-y"},{"key":"e_1_2_19_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn.2016.68"},{"key":"e_1_2_19_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(98)00394-1"},{"key":"e_1_2_19_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(84)90094-0"},{"key":"e_1_2_19_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2024.03.016"},{"key":"e_1_2_19_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/1744-8069-10-33"},{"key":"e_1_2_19_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-04309-2"},{"key":"e_1_2_19_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13041-020-00638-w"},{"key":"e_1_2_19_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/35042500"},{"key":"e_1_2_19_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2003.11.008"},{"key":"e_1_2_19_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-06748-w"},{"key":"e_1_2_19_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-019-0481-5"},{"key":"e_1_2_19_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2023.105362"},{"key":"e_1_2_19_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/1744806916652409"},{"key":"e_1_2_19_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(01)00479-2"},{"key":"e_1_2_19_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11916-019-0828-3"},{"key":"e_1_2_19_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2024.114669"},{"key":"e_1_2_19_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2014.12.021"},{"key":"e_1_2_19_22_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.123.002046"},{"key":"e_1_2_19_23_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP276935"},{"key":"e_1_2_19_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/14771"},{"key":"e_1_2_19_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/31496"},{"key":"e_1_2_19_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-020-00927-1"},{"key":"e_1_2_19_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-023-05589-1"},{"key":"e_1_2_19_28_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1191792"},{"key":"e_1_2_19_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13041-020-00583-8"},{"key":"e_1_2_19_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.14903"},{"key":"e_1_2_19_31_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1001283"},{"key":"e_1_2_19_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2016.10.029"},{"key":"e_1_2_19_33_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnana.2023.1131167"},{"key":"e_1_2_19_34_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.174.4016.1351"},{"key":"e_1_2_19_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(85)90119-2"},{"key":"e_1_2_19_36_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2015-312233"},{"key":"e_1_2_19_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902720205"},{"key":"e_1_2_19_38_1","doi-asserted-by":"publisher","DOI":"10.1101\/lm.053440.121"},{"key":"e_1_2_19_39_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000001748"},{"key":"e_1_2_19_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2023.04.002"},{"key":"e_1_2_19_41_1","doi-asserted-by":"crossref","unstructured":"Peng B. A. R.Foilb Y.Manasian et\u00a0al.2024. \u201cIntra\u2010Amygdala Circuits of Sleep Disruption\u2013Induced Anxiety in Female Mice.\u201d bioRxiv: the preprint server for biology.","DOI":"10.1101\/2024.05.19.594863"},{"key":"e_1_2_19_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(02)02157-4"},{"key":"e_1_2_19_43_1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.2003778"},{"key":"e_1_2_19_44_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199303000-00025"},{"key":"e_1_2_19_45_1","doi-asserted-by":"publisher","DOI":"10.1186\/1744-8069-5-45"},{"key":"e_1_2_19_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-022-00635-8"},{"key":"e_1_2_19_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2006.04968.x"},{"key":"e_1_2_19_48_1","doi-asserted-by":"publisher","DOI":"10.1177\/17448069221094529"},{"key":"e_1_2_19_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2008.12.003"},{"key":"e_1_2_19_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2017.11.042"},{"key":"e_1_2_19_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2947"},{"key":"e_1_2_19_52_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/813749"},{"key":"e_1_2_19_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2023.113125"},{"key":"e_1_2_19_54_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00423.2001"},{"key":"e_1_2_19_55_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3001269"},{"key":"e_1_2_19_56_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.76298"},{"key":"e_1_2_19_57_1","doi-asserted-by":"publisher","DOI":"10.1177\/17448069221089596"},{"key":"e_1_2_19_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2014.10.018"},{"key":"e_1_2_19_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0173(02)00202-3"},{"key":"e_1_2_19_60_1","doi-asserted-by":"publisher","DOI":"10.1177\/17448069241300990"},{"key":"e_1_2_19_61_1","doi-asserted-by":"publisher","DOI":"10.1177\/17448069221087034"},{"key":"e_1_2_19_62_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2023.0475"},{"key":"e_1_2_19_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(00)29008-0"},{"key":"e_1_2_19_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2008.01.003"},{"key":"e_1_2_19_65_1","doi-asserted-by":"publisher","DOI":"10.1186\/1756-6606-2-4"},{"key":"e_1_2_19_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2012.01.009"},{"key":"e_1_2_19_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2016.01.006"},{"key":"e_1_2_19_68_1","doi-asserted-by":"publisher","DOI":"10.1177\/1744806917699212"},{"key":"e_1_2_19_69_1","doi-asserted-by":"publisher","DOI":"10.1177\/17448069241230258"},{"key":"e_1_2_19_70_1","doi-asserted-by":"publisher","DOI":"10.1177\/17448069251414261"},{"key":"e_1_2_19_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(90)91147-B"},{"key":"e_1_2_19_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(91)90402-H"},{"key":"e_1_2_19_73_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1992.67.6.1599"},{"key":"e_1_2_19_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(92)91185-H"},{"key":"e_1_2_19_75_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1997.78.2.746"},{"key":"e_1_2_19_76_1","doi-asserted-by":"publisher","DOI":"10.1038\/368635a0"},{"key":"e_1_2_19_77_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.2002.87.5.2225"},{"key":"e_1_2_19_78_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.8100368"}],"container-title":["European Journal of Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ejn.70679","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ejn.70679","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ejn.70679","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T02:51:35Z","timestamp":1790563895000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ejn.70679"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":77,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1111\/ejn.70679"],"URL":"https:\/\/doi.org\/10.1111\/ejn.70679","archive":["Portico"],"relation":{},"ISSN":["0953-816X","1460-9568"],"issn-type":[{"value":"0953-816X","type":"print"},{"value":"1460-9568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"2026-05-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-31","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70679"}}