{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T02:56:20Z","timestamp":1790564180137,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T00:00:00Z","timestamp":1789862400000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J of Neuroscience"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Post\u2010stroke cognitive impairment (PSCI) affects nearly 30% of stroke survivors and substantially limits functional recovery. Brain\u2010derived neurotrophic factor (BDNF)\u2013tropomyosin receptor kinase\u2010\n                    <jats:italic>\u03b2<\/jats:italic>\n                    (Trk\n                    <jats:italic>\u03b2<\/jats:italic>\n                    ) signalling plays an important role in synaptic plasticity and cognitive function; however, the contribution of individual NTRK2\/Trk\n                    <jats:italic>\u03b2<\/jats:italic>\n                    isoforms to PSCI remains poorly understood. This study investigated (a) isoform\u2010specific NTRK2 mRNA expression, (b) genetic association of the isoform\u2010specific variant rs6559833 with post\u2010stroke cognitive outcomes and (c) DNA methylation patterns potentially regulating NTRK2 expression using blood as primary biosource. Isoform\u2010specific expression was analysed in 50 subjects, rs6559833 was genotyped in 280 ischemic stroke patients, and DNA methylation was assessed in 10 samples using whole\u2010genome bisulfite sequencing. The TRK\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2010FL expression was significantly reduced in stroke patients compared with healthy controls, whereas TRK\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2010SHC expression was higher in PSCN individuals than in PSCI patients. The latter showed positive correlation with MEK2 expression and memory performance. The \u2018TT\u2019 genotype of the rs6559833 variant showed marginal associations with post\u2010stroke memory status and overall BMSE scores (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.0442 and 0.0488, respectively). Furthermore, hypermethylation was observed within the NTRK2 gene body and in genes encoding its splicing regulators, whereas no evident difference in promoter methylation was observed. Collectively, these findings suggest that Trk\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2010SHC expression may be associated with preserved cognitive function after stroke and indicate a potential relationship between isoform\u2010specific NTRK2 expression, genetic regulation and cognitive outcomes in PSCI.\n                  <\/jats:p>","DOI":"10.1111\/ejn.70684","type":"journal-article","created":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:35:54Z","timestamp":1789950954000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Transcriptional Alteration in TRK\n                    <i>\u03b2<\/i>\n                    \u2010SHC Isoform as a Neuroprotective Factor for Post\u2010Stroke Memory Outcomes"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5525-3329","authenticated-orcid":false,"given":"Dipanwita","family":"Sadhukhan","sequence":"first","affiliation":[{"name":"Molecular Biology &amp; Clinical Neuroscience Division National Neurosciences Centre Calcutta  Kolkata India"},{"name":"Institute of Engineering and Management\u2010Newtown University of Engineering &amp; Management  Kolkata India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-7462-6046","authenticated-orcid":false,"given":"Raktim","family":"Chowdhury","sequence":"additional","affiliation":[{"name":"Structural Biology and Bioinformatics Division CSIR\u2010Indian Institute of Chemical Biology, IICB\u2010TRUE Campus  Kolkata India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saranya","family":"Roy","sequence":"additional","affiliation":[{"name":"Molecular Biology &amp; Clinical Neuroscience Division National Neurosciences Centre Calcutta  Kolkata India"},{"name":"Department of Biomedical Science &amp; Technology, School of Biological Sciences Ramakrishna Mission Vivekananda Educational &amp; Research Institute  Narendrapur India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arunima","family":"Roy","sequence":"additional","affiliation":[{"name":"Molecular Biology &amp; Clinical Neuroscience Division National Neurosciences Centre Calcutta  Kolkata India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shreyosi","family":"Maitra","sequence":"additional","affiliation":[{"name":"Department of Biomedical Science &amp; Technology, School of Biological Sciences Ramakrishna Mission Vivekananda Educational &amp; Research Institute  Narendrapur India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5706-5491","authenticated-orcid":false,"given":"Kartik Chandra","family":"Ghosh","sequence":"additional","affiliation":[{"name":"Department of Neurology Nil Ratan Sircar Medical College &amp; Hospital  Kolkata India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0056-1150","authenticated-orcid":false,"given":"Joydeep","family":"Mukherjee","sequence":"additional","affiliation":[{"name":"Department of Neurology Nil Ratan Sircar Medical College &amp; Hospital  Kolkata India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6923-7909","authenticated-orcid":false,"given":"Tapas Kumar","family":"Banerjee","sequence":"additional","affiliation":[{"name":"Molecular Biology &amp; Clinical Neuroscience Division National Neurosciences Centre Calcutta  Kolkata India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5018-4918","authenticated-orcid":false,"given":"Subhra Prakash","family":"Hui","sequence":"additional","affiliation":[{"name":"S. 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