{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T02:56:16Z","timestamp":1790564176042,"version":"4.1.0"},"reference-count":114,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J of Neuroscience"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Morin (3,5,7,2\u2032,4\u2032\u2010pentahydroxyflavone) is a dietary flavonol with broad neuroprotective, anti\u2010inflammatory, and antioxidant actions across central and peripheral nervous system models. This synthesis consolidates evidence from in\u00a0vitro and rodent studies\u2014covering neurodegenerative proteinopathies (Alzheimer's, Parkinson's, and Huntington's), neuropathic pain, epilepsy, stress\u2010 and schizophrenia\u2010like phenotypes, and chemo\u2010\/toxicant\u2010induced neurotoxicity\u2014to evaluate morin's consistent benefits on survival, motor\/cognitive performance, and biochemical normalization. Morin mitigated neurotoxicity induced by doxorubicin, ifosfamide, vincristine, acrylamide, heavy metals, and endocrine disruptors. Context\u2010specific effects included modulation of disease\u2010defining pathways (\n                    <jats:italic>GSK3\u03b2<\/jats:italic>\n                    \/CDK5, mTORC1, PARP, and AMPK\u2013ULK1\u2013TFEB), microglial polarization, and normalization of neurotransmission (dopamine, GABA, 5\u2010HT, and reduced AChE). Core mechanisms included the following: restoration of redox and mitochondrial homeostasis via\n                    <jats:italic>Nrf2<\/jats:italic>\n                    \/HO\u20101 activation; replenishment of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and glutathione (GSH); decreased reactive oxygen species (ROS), malondialdehyde (MDA), and nitric oxide (NO); and preserved mitochondrial potential\/fusion; suppression of innate immune and inflammasome signaling through downregulation of TLR4\/NF\u2010\u03baB and ERK\u2013p65, reduced TNF\u2010\u03b1, IL\u20101\u03b2\/IL\u20106, iNOS\/COX\u20102; inhibition of NLRP3\/caspase\u20101; and rebalancing of cell\u2010death programs (\u2193\n                    <jats:italic>Bax<\/jats:italic>\n                    \/caspase\u20103, \u2191\n                    <jats:italic>Bcl\u20102<\/jats:italic>\n                    ; attenuation of RIPK1\/RIPK3\/MLKL\u2010mediated necroptosis). Formulation strategies (intranasal microemulsions, pluronic micelles, and more soluble derivatives) have enhanced brain exposure and efficacy, but translation now warrants optimized delivery, pharmacokinetic\u2013pharmacodynamic mapping, target engagement biomarkers, and rigorously controlled trials to define dose, route, and indications as adjunctive to standard care in neurodegeneration, neuropathic pain, and toxicant\u2010related brain injury. Collectively, morin emerges as a multitarget neuroprotective scaffold with reproducible functional and mechanistic benefits.\n                  <\/jats:p>","DOI":"10.1111\/ejn.70692","type":"journal-article","created":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T04:33:56Z","timestamp":1789619636000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Neuroprotective Effect of Morin Against Chemical\u2010Induced Neurotoxicities and Neurodegenerative Disease Models"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3078-119X","authenticated-orcid":false,"given":"Bidemi Emmanuel","family":"Ekundayo","sequence":"first","affiliation":[{"name":"Department of Biochemistry Bamidele Olumilua University of Science and Technology  Ikere Ekiti Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motunrayo Comfort","family":"Ekundayo","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, College of Sciences Afe Babalola University  Ado\u2010Ekiti Nigeria"},{"name":"Department of Biochemistry, Faculty of Natural and Applied Science Federal University of Technology and Environmental Sciences  Iyin Ekiti Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunday Ayodele","family":"Alonge","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Bamidele Olumilua University of Science and Technology  Ikere Ekiti Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blessing Ariyo","family":"Obafemi","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry Afe Babalola University  Ado\u2010Ekiti Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tajudeen Olabisi","family":"Obafemi","sequence":"additional","affiliation":[{"name":"Department of Life and Consumer Sciences University of South Africa, Florida 1709  Johannesburg South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sogolo Lucky","family":"Lebelo","sequence":"additional","affiliation":[{"name":"Department of Life and Consumer Sciences University of South Africa, Florida 1709  Johannesburg South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monde McMillan","family":"Ntwasa","sequence":"additional","affiliation":[{"name":"Department of Life and Consumer Sciences University of South Africa, Florida 1709  Johannesburg South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,16]]},"reference":[{"key":"e_1_2_16_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2017.27"},{"key":"e_1_2_16_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2022.175213"},{"key":"e_1_2_16_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-96511-6_2"},{"key":"e_1_2_16_5_1","doi-asserted-by":"publisher","DOI":"10.32598\/bcn.2022.1059.2"},{"key":"e_1_2_16_6_1","unstructured":"Alam A. andN.Subhan.2023. \u201cMorin a Promising Phytochemicals for the Treatment of Diabetes and Dyslipidemia.\u201dhttps:\/\/doi.org\/10.13140\/RG.2.2.28143.20646."},{"key":"e_1_2_16_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-026-12141-x"},{"key":"e_1_2_16_8_1","doi-asserted-by":"publisher","DOI":"10.2147\/JEP.S498984"},{"key":"e_1_2_16_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2019.22360"},{"key":"e_1_2_16_10_1","doi-asserted-by":"publisher","DOI":"10.5114\/fn.2019.85929"},{"key":"e_1_2_16_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2025.115466"},{"key":"e_1_2_16_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/biof.1397"},{"key":"e_1_2_16_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.14108"},{"key":"e_1_2_16_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-024-04407-x"},{"key":"e_1_2_16_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2019.02.052"},{"key":"e_1_2_16_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064\u2010018\u20102590\u2010z"},{"key":"e_1_2_16_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(21)00218\u2010X"},{"key":"e_1_2_16_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.671257"},{"key":"e_1_2_16_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/1028415X.2022.2094855"},{"key":"e_1_2_16_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuro.2019.11.004"},{"key":"e_1_2_16_21_1","doi-asserted-by":"publisher","DOI":"10.21010\/ajtcam.v14i2.36"},{"key":"e_1_2_16_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2008.04.019"},{"key":"e_1_2_16_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10517\u2010021\u201005191\u20107"},{"issue":"10","key":"e_1_2_16_24_1","first-page":"232","article-title":"Antidiabetic and Antihyperlipidemic Effects of Methanolic Extract of Citrullus lanatus Seeds in Rats","volume":"7","author":"Deshmukh C. 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