{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T11:41:48Z","timestamp":1792582908477,"version":"4.5.0"},"reference-count":239,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T00:00:00Z","timestamp":1792540800000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J of Neuroscience"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Microglia are the immune cells resident in the central nervous system (CNS) and are involved in CNS homeostasis and in responses to injury and disease. Microglia, upon activation, become pro\u2010inflammatory (M1) or anti\u2010inflammatory (M2), with M1 being neurotoxic and M2 participating in tissue repair. The activation of microglia in neuroinflammation and pain hypersensitivity is important in the neurodegenerative disorders such as Parkinson's (PD) and Alzheimer's disease (\n                    <jats:sc>AD<\/jats:sc>\n                    ). Recent investigations have identified GLP\u20101 receptor agonists (GLP\u20101 RAs) as potent pharmacological agents that can regulate the activity of the microglia. GLP\u20101RA attaches to the GLP\u20101 receptor found on the microglia to cause a phenotypic shift to the anti\u2010inflammatory M2 form, which, in turn, reduces neuroinflammation and increases neuronal protection. Experimental evidence shows that GLP\u20101 RAs are effective at reducing hypersensitivity to pain, improving cognitive performance, and attenuating inflammatory effects in preclinical models of\n                    <jats:sc>AD<\/jats:sc>\n                    , PD, and multiple sclerosis (MS). All these facts suggest that GLP\u20101 RAs are a significant treatment option in chronic pain and neurodegenerative disease management, as they can change microglial polarization and suppress neuroinflammation.\n                  <\/jats:p>","DOI":"10.1111\/ejn.70718","type":"journal-article","created":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T11:00:23Z","timestamp":1792580423000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Modulating Microglial Activation Through GLP\u20101 Pathways: A New Frontier in Neuroinflammation Research"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4115-4914","authenticated-orcid":false,"given":"S. Mohana","family":"Lakshmi","sequence":"first","affiliation":[{"name":"Amity Institute of Pharmacy Amity University Bengaluru  Bengaluru Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-7283-6008","authenticated-orcid":false,"given":"Vijay","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Technology, School of Allied Health Sciences Galgotias University  Greater Noida Gautam Buddha Nagar, Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9792-5605","authenticated-orcid":false,"given":"Murugesan","family":"Vanangamudi","sequence":"additional","affiliation":[{"name":"Institute of Pharmaceutical Research GLA University  Mathura Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8475-7021","authenticated-orcid":false,"given":"Tahreen","family":"Taj","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Yenepoya Pharmacy College and Research Centre Yenepoya (Deemed to be) University  Mangalore India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2538-6654","authenticated-orcid":false,"given":"Haleema","family":"Shahin DH","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Yenepoya Pharmacy College and Research Centre Yenepoya (Deemed to be) University  Mangalore India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5761-7958","authenticated-orcid":false,"given":"Rajarshi","family":"Nath","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Technology Bharat Technology  Uluberia West Bengal India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9838-2147","authenticated-orcid":false,"given":"Gouranga","family":"Dutta","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, SRM College of Pharmacy, Faculty of Medicine and Health Sciences SRM Institute of Science and Technology  Kattankulathur Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjeeva Kumar","family":"Avvari","sequence":"additional","affiliation":[{"name":"Amity Institute of Pharmacy Amity University Bengaluru  Bengaluru Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sathvik Belagodu","family":"Sridhar","sequence":"additional","affiliation":[{"name":"College of Pharmacy Dubai Medical University  Dubai UAE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8142-044X","authenticated-orcid":false,"given":"Uttam Prasad","family":"Panigrahy","sequence":"additional","affiliation":[{"name":"Jeypore College of Pharmacy  Rondapalli, Jeypore Koraput, Odisha India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8667-7340","authenticated-orcid":false,"given":"Nadira","family":"Noushida","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Yenepoya Medical College Yenepoya (Deemed to be) University  Mangalore India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7901-0006","authenticated-orcid":false,"given":"Priya","family":"Chaudhary","sequence":"additional","affiliation":[{"name":"Centre for Herbal Pharmacology and Environmental Sustainability, Chettinad Hospital and Research Institute Chettinad Academy of Research and Education  Kelambakkam Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,21]]},"reference":[{"issue":"4","key":"e_1_2_22_2_1","doi-asserted-by":"crossref","DOI":"10.3390\/cimb47040285","article-title":"The Expanding Role of GLP\u20101 Receptor Agonists: Advancing Clinical Outcomes in Metabolic and Mental Health","volume":"47","author":"Al Qassab M.","year":"2025","journal-title":"Current Issues in Molecular Biology"},{"key":"e_1_2_22_3_1","doi-asserted-by":"crossref","DOI":"10.1177\/20420188231222367","article-title":"Anti\u2010Inflammatory Role of Glucagon\u2010Like Peptide 1 Receptor Agonists and Its Clinical Implications","volume":"15","author":"Alharbi S. H.","year":"2024","journal-title":"Therapeutic Advances in Endocrinology and Metabolism"},{"issue":"3","key":"e_1_2_22_4_1","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1007\/s10787-022-00956-6","article-title":"Neuroprotective Effect of Liraglutide in an Experimental Mouse Model of Multiple Sclerosis: Role of AMPK\/SIRT1 Signaling and NLRP3 Inflammasome","volume":"30","author":"Ammar R. A.","year":"2022","journal-title":"Inflammopharmacology"},{"key":"e_1_2_22_5_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2025.108824","article-title":"GLP\u20101 Receptor Agonists, Are We Witnessing the Emergence of a Paradigm Shift for Neuro\u2010Cardio\u2010Metabolic Disorders","volume":"269","author":"Arredouani A.","year":"2025","journal-title":"Pharmacology & Therapeutics"},{"issue":"5","key":"e_1_2_22_6_1","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1016\/j.drudis.2016.01.013","article-title":"The Glucagon\u2010Like Peptide 1 (GLP) Receptor as a Therapeutic Target in Parkinson's Disease: Mechanisms of Action","volume":"21","author":"Athauda D.","year":"2016","journal-title":"Drug Discovery Today"},{"issue":"4","key":"e_1_2_22_7_1","doi-asserted-by":"crossref","DOI":"10.1172\/JCI194745","article-title":"The Promise of GLP\u20101 Receptor Agonists for Neurodegenerative Diseases","volume":"136","author":"Athauda D.","year":"2026","journal-title":"Journal of Clinical Investigation"},{"issue":"10103","key":"e_1_2_22_8_1","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1016\/S0140-6736(17)31585-4","article-title":"Exenatide Once Weekly Versus Placebo in Parkinson's Disease: A Randomised, Double\u2010Blind, Placebo\u2010Controlled Trial","volume":"390","author":"Athauda D.","year":"2017","journal-title":"Lancet"},{"issue":"3","key":"e_1_2_22_9_1","doi-asserted-by":"crossref","first-page":"337","DOI":"10.3233\/JPD-140364","article-title":"Motor and Cognitive Advantages Persist 12 Months After Exenatide Exposure in Parkinson's Disease","volume":"4","author":"Aviles\u2010Olmos I.","year":"2014","journal-title":"Journal of Parkinson's Disease"},{"key":"e_1_2_22_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.medj.2025.100916"},{"key":"e_1_2_22_11_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.msard.2024.106229","article-title":"Glucagon\u2010Like Peptide\u20101 Agonist Safety and Efficacy in a Multiple Sclerosis Cohort","volume":"93","author":"Balshi A.","year":"2025","journal-title":"Multiple Sclerosis and Related Disorders"},{"issue":"1","key":"e_1_2_22_12_1","doi-asserted-by":"crossref","DOI":"10.1186\/s12576-024-00904-9","article-title":"Satiety: A Gut\u2010Brain\u2010Relationship","volume":"74","author":"Barakat G. M.","year":"2024","journal-title":"Journal of Physiological Sciences"},{"issue":"3","key":"e_1_2_22_13_1","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s40263-018-0593-6","article-title":"Neuroprotective Actions of Glucagon\u2010Like Peptide\u20101 (GLP\u20101) Analogues in Alzheimer's and Parkinson's Diseases","volume":"33","author":"Batista A. F.","year":"2019","journal-title":"CNS Drugs"},{"issue":"1","key":"e_1_2_22_14_1","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-026-74038-4","article-title":"Semaglutide Attenuates Neuroinflammation in Male Mice","volume":"17","author":"Belmont\u2010Rausch D. M.","year":"2026","journal-title":"Nature Communications"},{"issue":"2","key":"e_1_2_22_15_1","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1002\/jnr.21483","article-title":"Peptide Hormone Exendin\u20104 Stimulates Subventricular Zone Neurogenesis in the Adult Rodent Brain and Induces Recovery in an Animal Model of Parkinson's Disease","volume":"86","author":"Bertilsson G.","year":"2008","journal-title":"Journal of Neuroscience Research"},{"issue":"1","key":"e_1_2_22_16_1","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/S1474-4422(05)70284-2","article-title":"Risk of Dementia in Diabetes Mellitus: A Systematic Review","volume":"5","author":"Biessels G. J.","year":"2006","journal-title":"Lancet Neurology"},{"issue":"5","key":"e_1_2_22_17_1","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1002\/bcp.70021","article-title":"Safety and Effectiveness of the Anti\u2010Amyloid Monoclonal Antibody (mAb) Drug Lecanemab for Early Alzheimer's Disease: The Pharmacovigilance Perspective","volume":"91","author":"Bobbins A.","year":"2025","journal-title":"British Journal of Clinical Pharmacology"},{"issue":"10","key":"e_1_2_22_18_1","doi-asserted-by":"crossref","first-page":"2194","DOI":"10.1016\/j.immuni.2021.09.014","article-title":"Microglia: Immune and Non\u2010Immune Functions","volume":"54","author":"Borst K.","year":"2021","journal-title":"Immunity"},{"issue":"3","key":"e_1_2_22_19_1","doi-asserted-by":"crossref","first-page":"354","DOI":"10.4093\/dmj.2023.0277","article-title":"Glucagon\u2010Like Peptide\u20101: New Regulator in Lipid Metabolism","volume":"48","author":"Bu T.","year":"2024","journal-title":"Diabetes & Metabolism Journal"},{"issue":"1","key":"e_1_2_22_20_1","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1002\/ana.24304","article-title":"Targeting miR\u2010155 Restores Abnormal Microglia and Attenuates Disease in SOD1 Mice","volume":"77","author":"Butovsky O.","year":"2015","journal-title":"Annals of Neurology"},{"issue":"1","key":"e_1_2_22_21_1","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/nn.3599","article-title":"Identification of a Unique TGF\u2010Beta\u2010Dependent Molecular and Functional Signature in Microglia","volume":"17","author":"Butovsky O.","year":"2014","journal-title":"Nature Neuroscience"},{"issue":"1","key":"e_1_2_22_22_1","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1016\/j.bbrc.2017.11.114","article-title":"Lixisenatide Reduces Amyloid Plaques, Neurofibrillary Tangles and Neuroinflammation in an APP\/PS1\/Tau Mouse Model of Alzheimer's Disease","volume":"495","author":"Cai H. Y.","year":"2018","journal-title":"Biochemical and Biophysical Research Communications"},{"issue":"12","key":"e_1_2_22_23_1","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1007\/s40263-015-0301-8","article-title":"Novel GLP\u20101 (Glucagon\u2010Like Peptide\u20101) Analogues and Insulin in the Treatment for Alzheimer's Disease and Other Neurodegenerative Diseases","volume":"29","author":"Calsolaro V.","year":"2015","journal-title":"CNS Drugs"},{"issue":"6","key":"e_1_2_22_24_1","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/j.cmet.2013.04.008","article-title":"Pharmacology, Physiology, and Mechanisms of Incretin Hormone Action","volume":"17","author":"Campbell J. E.","year":"2013","journal-title":"Cell Metabolism"},{"issue":"2","key":"e_1_2_22_25_1","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1007\/s11011-021-00879-1","article-title":"Neuroprotective Effects of Liraglutide Against Inflammation Through the AMPK\/NF\u2010kappaB Pathway in a Mouse Model of Parkinson's Disease","volume":"37","author":"Cao B.","year":"2022","journal-title":"Metabolic Brain Disease"},{"issue":"2","key":"e_1_2_22_26_1","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1007\/s11011-021-00879-1","article-title":"Neuroprotective Effects of Liraglutide Against Inflammation Through the AMPK\/NF\u2010\u03baB Pathway in a Mouse Model of Parkinson's Disease","volume":"37","author":"Cao B.","year":"2022","journal-title":"Metabolic Brain Disease"},{"issue":"3","key":"e_1_2_22_27_1","doi-asserted-by":"crossref","DOI":"10.3390\/neuroglia6030031","article-title":"Microglia and Macrophages in Central Nervous System Homeostasis and Disease Progression: Guardians and Executioners","volume":"6","author":"Chamkouri H.","year":"2025","journal-title":"Neuroglia"},{"issue":"11","key":"e_1_2_22_28_1","doi-asserted-by":"crossref","DOI":"10.3390\/brainsci11111482","article-title":"Differential Cytokine\u2010Induced Responses of Polarized Microglia","volume":"11","author":"Chauhan P.","year":"2021","journal-title":"Brain Sciences"},{"issue":"10","key":"e_1_2_22_29_1","doi-asserted-by":"crossref","first-page":"2173","DOI":"10.1016\/j.cmet.2024.09.003","article-title":"GLP\u20101 Programs the Neurovascular Landscape","volume":"36","author":"Chen B.","year":"2024","journal-title":"Cell Metabolism"},{"issue":"1","key":"e_1_2_22_30_1","doi-asserted-by":"crossref","first-page":"18063","DOI":"10.1038\/s41598-025-01206-9","article-title":"Pharmacovigilance Analysis of Neurological Adverse Events Associated With GLP\u20101 Receptor Agonists Based on the FDA Adverse Event Reporting System","volume":"15","author":"Chen H.","year":"2025","journal-title":"Scientific Reports"},{"issue":"8","key":"e_1_2_22_31_1","doi-asserted-by":"crossref","first-page":"2326","DOI":"10.1007\/s11064-017-2250-8","article-title":"Liraglutide Improves Water Maze Learning and Memory Performance While Reduces Hyperphosphorylation of Tau and Neurofilaments in APP\/PS1\/Tau Triple Transgenic Mice","volume":"42","author":"Chen S.","year":"2017","journal-title":"Neurochemical Research"},{"key":"e_1_2_22_32_1","doi-asserted-by":"crossref","first-page":"665","DOI":"10.2147\/DDDT.S348055","article-title":"The Role of Glucagon\u2010Like Peptide\u20101 Receptor Agonists (GLP\u20101 RA) in Diabetes\u2010Related Neurodegenerative Diseases","volume":"16","author":"Cheng D.","year":"2023","journal-title":"Drug Design, Development and Therapy"},{"issue":"1","key":"e_1_2_22_33_1","doi-asserted-by":"crossref","DOI":"10.1186\/s13024-018-0262-8","article-title":"The T Rem 2 R47H Variant Confers Loss\u2010of\u2010Function\u2010Like Phenotypes in Alzheimer's Disease","volume":"13","author":"Cheng\u2010Hathaway P. J.","year":"2018","journal-title":"Molecular Neurodegeneration"},{"issue":"2","key":"e_1_2_22_34_1","doi-asserted-by":"crossref","DOI":"10.3390\/biom15020291","article-title":"G\u2010Protein\u2010Coupled Receptor (GPCR) Signaling and Pharmacology in Metabolism: Physiology, Mechanisms, and Therapeutic Potential","volume":"15","author":"Cho Y. Y.","year":"2025","journal-title":"Biomolecules"},{"issue":"3","key":"e_1_2_22_35_1","doi-asserted-by":"crossref","first-page":"F545","DOI":"10.1152\/ajprenal.00197.2023","article-title":"Collecting Duct Water Permeability Inhibition by EGF Is Associated With Decreased cAMP, PKA Activity, and AQP2 Phosphorylation at Ser269","volume":"326","author":"Chou C.\u2010L.","year":"2024","journal-title":"American Journal of Physiology. Renal Physiology"},{"issue":"9","key":"e_1_2_22_36_1","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/j.it.2016.06.006","article-title":"Astrocytes: Key Regulators of Neuroinflammation","volume":"37","author":"Colombo E.","year":"2016","journal-title":"Trends in Immunology"},{"key":"e_1_2_22_37_1","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1146\/annurev-immunol-051116-052358","article-title":"Microglia Function in the Central Nervous System During Health and Neurodegeneration","volume":"35","author":"Colonna M.","year":"2017","journal-title":"Annual Review of Immunology"},{"issue":"1","key":"e_1_2_22_38_1","doi-asserted-by":"crossref","DOI":"10.1038\/s41421-024-00649-0","article-title":"Molecular Features of the Ligand\u2010Free GLP\u20101R, GCGR and GIPR in Complex With Gs Proteins","volume":"10","author":"Cong Z.","year":"2024","journal-title":"Cell Discovery"},{"issue":"10","key":"e_1_2_22_39_1","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1016\/j.molmet.2015.07.008","article-title":"Distribution and Characterisation of Glucagon\u2010Like Peptide\u20101 Receptor Expressing Cells in the Mouse Brain","volume":"4","author":"Cork S. C.","year":"2015","journal-title":"Molecular Metabolism"},{"issue":"4","key":"e_1_2_22_40_1","doi-asserted-by":"crossref","first-page":"705","DOI":"10.4103\/1673-5374.322423","article-title":"Microglia Regulation of Synaptic Plasticity and Learning and Memory","volume":"17","author":"Cornell J.","year":"2022","journal-title":"Neural Regeneration Research"},{"issue":"1","key":"e_1_2_22_41_1","doi-asserted-by":"crossref","DOI":"10.1186\/s13195-024-01666-7","article-title":"Evoke and Evoke+: Design of Two Large\u2010Scale, Double\u2010Blind, Placebo\u2010Controlled, Phase 3 Studies Evaluating Efficacy, Safety, and Tolerability of Semaglutide in Early\u2010Stage Symptomatic Alzheimer's Disease","volume":"17","author":"Cummings J. L.","year":"2025","journal-title":"Alzheimer's Research & Therapy"},{"issue":"10544","key":"e_1_2_22_42_1","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.1016\/S0140-6736(26)00459-9","article-title":"Efficacy and Safety of Oral Semaglutide 14 mg (Flexible Dose) in Early\u2010Stage Symptomatic Alzheimer's Disease (Evoke and Evoke+): Two Phase 3, Randomised, Placebo\u2010Controlled Trials","volume":"407","author":"Cummings J. L.","year":"2026","journal-title":"Lancet"},{"issue":"1","key":"e_1_2_22_43_1","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.3233\/JAD-179901","article-title":"Clinical Trials for Disease\u2010Modifying Therapies in Alzheimer's Disease: A Primer, Lessons Learned, and a Blueprint for the Future","volume":"64","author":"Cummings J.","year":"2018","journal-title":"Journal of Alzheimer's Disease"},{"issue":"7","key":"e_1_2_22_44_1","doi-asserted-by":"crossref","first-page":"2262","DOI":"10.2337\/db13-1954","article-title":"Inflammation, Defective Insulin Signaling, and Mitochondrial Dysfunction as Common Molecular Denominators Connecting Type 2 Diabetes to Alzheimer Disease","volume":"63","author":"De Felice F. G.","year":"2014","journal-title":"Diabetes"},{"issue":"1","key":"e_1_2_22_45_1","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s40265-016-0674-0","article-title":"Insulin Resistance and Neurodegeneration: Progress Towards the Development of New Therapeutics for Alzheimer's Disease","volume":"77","author":"Monte S. M.","year":"2017","journal-title":"Drugs"},{"issue":"5","key":"e_1_2_22_46_1","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1016\/j.cell.2018.05.003","article-title":"Disease\u2010Associated Microglia: A Universal Immune Sensor of Neurodegeneration","volume":"173","author":"Deczkowska A.","year":"2018","journal-title":"Cell"},{"issue":"1","key":"e_1_2_22_47_1","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-021-27760-0","article-title":"Dynamics of GLP\u20101R Peptide Agonist Engagement Are Correlated With Kinetics of G Protein Activation","volume":"13","author":"Deganutti G.","year":"2022","journal-title":"Nature Communications"},{"issue":"5","key":"e_1_2_22_48_1","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1021\/acschemneuro.4c00729","article-title":"Dual GLP\u20101 and GIP Agonist Tirzepatide Exerted Neuroprotective Action in a Parkinson's Disease Rat Model","volume":"16","author":"Delvadia P.","year":"2025","journal-title":"ACS Chemical Neuroscience"},{"issue":"11","key":"e_1_2_22_49_1","doi-asserted-by":"crossref","DOI":"10.3390\/nu12113304","article-title":"Glucagon\u2010Like Peptide\u20101 (GLP\u20101) in the Integration of Neural and Endocrine Responses to Stress","volume":"12","author":"Diz\u2010Chaves Y.","year":"2020","journal-title":"Nutrients"},{"issue":"8","key":"e_1_2_22_50_1","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.4103\/1673-5374.389626","article-title":"Glucagon\u2010Like Peptide 1 Receptor Activation: Anti\u2010Inflammatory Effects in the Brain","volume":"19","author":"Diz\u2010Chaves Y.","year":"2024","journal-title":"Neural Regeneration Research"},{"issue":"17","key":"e_1_2_22_51_1","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23179583","article-title":"Anti\u2010Inflammatory Effects of GLP\u20101 Receptor Activation in the Brain in Neurodegenerative Diseases","volume":"23","author":"Diz\u2010Chaves Y.","year":"2022","journal-title":"International Journal of Molecular Sciences"},{"issue":"5","key":"e_1_2_22_52_1","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21051746","article-title":"Liraglutide Protects Against Brain Amyloid\u2010\u03b2(1\u201042) Accumulation in Female Mice With Early Alzheimer's Disease\u2010Like Pathology by Partially Rescuing Oxidative\/Nitrosative Stress and Inflammation","volume":"21","author":"Duarte A. I.","year":"2020","journal-title":"International Journal of Molecular Sciences"},{"key":"e_1_2_22_53_1","doi-asserted-by":"crossref","DOI":"10.1002\/alz.089799","article-title":"Evaluation of Novel GLP\u20101 Analogue in the Treatment of Alzheimer's Disease","volume":"20","author":"Edison P.","year":"2024","journal-title":"Alzheimer's & Dementia"},{"issue":"1","key":"e_1_2_22_54_1","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1038\/s41591-025-04106-7","article-title":"Liraglutide in Mild to Moderate Alzheimer's Disease: A Phase 2b Clinical Trial","volume":"32","author":"Edison P.","year":"2026","journal-title":"Nature Medicine"},{"issue":"2","key":"e_1_2_22_55_1","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.diabres.2014.04.006","article-title":"Inflammation as a Link Between Obesity, Metabolic Syndrome and Type 2 Diabetes","volume":"105","author":"Esser N.","year":"2014","journal-title":"Diabetes Research and Clinical Practice"},{"issue":"14","key":"e_1_2_22_56_1","doi-asserted-by":"crossref","first-page":"3038","DOI":"10.1038\/emboj.2012.170","article-title":"Mitochondrial Dysfunction in Parkinson's Disease: Molecular Mechanisms and Pathophysiological Consequences","volume":"31","author":"Exner N.","year":"2012","journal-title":"EMBO Journal"},{"issue":"1","key":"e_1_2_22_57_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2026.118074","article-title":"A Novel Bifunctional Peptide Predicted to Target Neuropeptide Y4 and GLP\u20101 Receptors Alleviates Cognitive Deficits in 5 x FAD Mice by Modulating cGAS\u2010STING\u2010Mediated Neuroinflammation","volume":"251","author":"Feng Y.","year":"2026","journal-title":"Biochemical Pharmacology"},{"issue":"1","key":"e_1_2_22_58_1","article-title":"Parkinson's Disease and Systemic Inflammation","volume":"2011","author":"Ferrari C. C.","year":"2011","journal-title":"Parkinson's Disease"},{"issue":"12","key":"e_1_2_22_59_1","doi-asserted-by":"crossref","first-page":"1806","DOI":"10.4049\/jimmunol.2300102","article-title":"Glucagon\u2010Like Peptide\u20101 Receptor Pathway Attenuates Platelet Activation in Aspirin\u2010Exacerbated Respiratory Disease","volume":"211","author":"Foer D.","year":"2023","journal-title":"Journal of Immunology"},{"issue":"6","key":"e_1_2_22_60_1","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24065914","article-title":"Alpha Synuclein: Neurodegeneration and Inflammation","volume":"24","author":"Forloni G.","year":"2023","journal-title":"International Journal of Molecular Sciences"},{"issue":"8","key":"e_1_2_22_61_1","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1038\/nn.4597","article-title":"Transcriptomic Analysis of Purified Human Cortical Microglia Reveals Age\u2010Associated Changes","volume":"20","author":"Galatro T. F.","year":"2017","journal-title":"Nature Neuroscience"},{"issue":"26","key":"e_1_2_22_62_1","doi-asserted-by":"crossref","first-page":"6019","DOI":"10.1021\/acs.jafc.5b01238","article-title":"Effects of D\u2010Pinitol on Insulin Resistance Through the PI3K\/Akt Signaling Pathway in Type 2 Diabetes Mellitus Rats","volume":"63","author":"Gao Y.","year":"2015","journal-title":"Journal of Agricultural and Food Chemistry"},{"issue":"1","key":"e_1_2_22_63_1","doi-asserted-by":"crossref","first-page":"R33","DOI":"10.1186\/ar2941","article-title":"Akt Activity Protects Rheumatoid Synovial Fibroblasts From Fas\u2010Induced Apoptosis by Inhibition of Bid Cleavage","volume":"12","author":"Garcia S.","year":"2010","journal-title":"Arthritis Research & Therapy"},{"issue":"6","key":"e_1_2_22_64_1","doi-asserted-by":"crossref","DOI":"10.3390\/cimb47060417","article-title":"Neuroinflammation: Mechanisms, Dual Roles, and Therapeutic Strategies in Neurological Disorders","volume":"47","author":"Garcia\u2010Dominguez M.","year":"2025","journal-title":"Current Issues in Molecular Biology"},{"issue":"7","key":"e_1_2_22_65_1","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1016\/j.cell.2019.11.010","article-title":"Cross\u2010Species Single\u2010Cell Analysis Reveals Divergence of the Primate Microglia Program","volume":"179","author":"Geirsdottir L.","year":"2019","journal-title":"Cell"},{"issue":"1","key":"e_1_2_22_66_1","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-17718-y","article-title":"Blood\u2010Brain Glucose Transfer in Alzheimer's Disease: Effect of GLP\u20101 Analog Treatment","volume":"7","author":"Gejl M.","year":"2017","journal-title":"Scientific Reports"},{"key":"e_1_2_22_67_1","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2016.00108","article-title":"In Alzheimer's Disease, 6\u2010Month Treatment With GLP\u20101 Analog Prevents Decline of Brain Glucose Metabolism: Randomized, Placebo\u2010Controlled, Double\u2010Blind Clinical Trial","volume":"8","author":"Gejl M.","year":"2016","journal-title":"Frontiers in Aging Neuroscience"},{"issue":"2","key":"e_1_2_22_68_1","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.nbd.2005.08.002","article-title":"In Vivo Imaging of Microglial Activation With [11C](R)\u2010PK11195 PET in Idiopathic Parkinson's Disease","volume":"21","author":"Gerhard A.","year":"2006","journal-title":"Neurobiology of Disease"},{"issue":"10193","key":"e_1_2_22_69_1","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0140-6736(19)31149-3","article-title":"Dulaglutide and Cardiovascular Outcomes in Type 2 Diabetes (REWIND): A Double\u2010Blind, Randomised Placebo\u2010Controlled Trial","volume":"394","author":"Gerstein H. C.","year":"2019","journal-title":"Lancet"},{"issue":"4","key":"e_1_2_22_70_1","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1007\/s13311-023-01390-4","article-title":"The Effects of NLY01, a Novel Glucagon\u2010Like Peptide\u20101 Receptor Agonist, on Cuprizone\u2010Induced Demyelination and Remyelination: Challenges and Future Perspectives: Therapeutic Potential of a GLP\u20101R Agonist in Cuprizone Models","volume":"20","author":"Gharagozloo M.","year":"2023","journal-title":"Neurotherapeutics"},{"issue":"3","key":"e_1_2_22_71_1","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.1007\/s13311-021-01088-5","article-title":"Therapeutic Potential of a Novel Glucagon\u2010Like Peptide\u20101 Receptor Agonist, NLY01, in Experimental Autoimmune Encephalomyelitis","volume":"18","author":"Gharagozloo M.","year":"2021","journal-title":"Neurotherapeutics"},{"key":"e_1_2_22_72_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbrep.2025.102037","article-title":"Type 2 Diabetes Mellitus\u2013Conventional Therapies and Future Perspectives in Innovative Treatment","volume":"42","author":"Gieroba B.","year":"2025","journal-title":"Biochemistry and Biophysics Reports"},{"issue":"6344","key":"e_1_2_22_73_1","doi-asserted-by":"crossref","DOI":"10.1126\/science.aal3222","article-title":"An Environment\u2010Dependent Transcriptional Network Specifies Human Microglia Identity","volume":"356","author":"Gosselin D.","year":"2017","journal-title":"Science"},{"issue":"3","key":"e_1_2_22_74_1","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.cmet.2012.06.015","article-title":"Hindbrain Neurons as an Essential Hub in the Neuroanatomically Distributed Control of Energy Balance","volume":"16","author":"Grill H. J.","year":"2012","journal-title":"Cell Metabolism"},{"key":"e_1_2_22_75_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2021.108048","article-title":"Imaging Neuroinflammation With TSPO: A New Perspective on the Cellular Sources and Subcellular Localization","volume":"234","author":"Guilarte T. R.","year":"2022","journal-title":"Pharmacology & Therapeutics"},{"issue":"4","key":"e_1_2_22_76_1","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.tins.2017.02.005","article-title":"Obesity\u2010Induced Neuroinflammation: Beyond the Hypothalamus","volume":"40","author":"Guillemot\u2010Legris O.","year":"2017","journal-title":"Trends in Neurosciences"},{"key":"e_1_2_22_77_1","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2022.815347","article-title":"Microglia Polarization From M1 to M2 in Neurodegenerative Diseases","volume":"14","author":"Guo S.","year":"2022","journal-title":"Frontiers in Aging Neuroscience"},{"key":"e_1_2_22_78_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2023.101762","article-title":"Discovery of Ecnoglutide\u2013A Novel, Long\u2010Acting, cAMP\u2010Biased Glucagon\u2010Like Peptide\u20101 (GLP\u20101) Analog","volume":"75","author":"Guo W.","year":"2023","journal-title":"Molecular Metabolism"},{"issue":"7883","key":"e_1_2_22_79_1","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1038\/s41586-021-03960-y","article-title":"Neurotoxic Reactive Astrocytes Induce Cell Death via Saturated Lipids","volume":"599","author":"Guttenplan K. A.","year":"2021","journal-title":"Nature"},{"key":"e_1_2_22_80_1","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.ejphar.2017.12.015","article-title":"Eriodictyol Stimulates Insulin Secretion Through cAMP\/PKA Signaling Pathway in Mice Islets","volume":"820","author":"Hameed A.","year":"2018","journal-title":"European Journal of Pharmacology"},{"issue":"4","key":"e_1_2_22_81_1","doi-asserted-by":"crossref","first-page":"877","DOI":"10.3233\/JAD-143090","article-title":"The GLP\u20101 Receptor Agonist Liraglutide Improves Memory Function and Increases Hippocampal CA1 Neuronal Numbers in a Senescence\u2010Accelerated Mouse Model of Alzheimer's Disease","volume":"46","author":"Hansen H. H.","year":"2015","journal-title":"Journal of Alzheimer's Disease"},{"issue":"4","key":"e_1_2_22_82_1","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/S1474-4422(15)70016-5","article-title":"Neuroinflammation in Alzheimer's Disease","volume":"14","author":"Heneka M. T.","year":"2015","journal-title":"Lancet Neurology"},{"issue":"3","key":"e_1_2_22_83_1","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1038\/ni.3102","article-title":"Innate Immunity in Alzheimer's Disease","volume":"16","author":"Heneka M. T.","year":"2015","journal-title":"Nature Immunology"},{"issue":"12","key":"e_1_2_22_84_1","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1038\/nrendo.2015.173","article-title":"Impaired Insulin Action in the Human Brain: Causes and Metabolic Consequences","volume":"11","author":"Heni M.","year":"2015","journal-title":"Nature Reviews. Endocrinology"},{"issue":"33","key":"e_1_2_22_85_1","doi-asserted-by":"crossref","first-page":"8354","DOI":"10.1523\/JNEUROSCI.0616-08.2008","article-title":"Microglial Dysfunction and Defective Beta\u2010Amyloid Clearance Pathways in Aging Alzheimer's Disease Mice","volume":"28","author":"Hickman S. E.","year":"2008","journal-title":"Journal of Neuroscience: The Official Journal of the Society for Neuroscience"},{"issue":"10","key":"e_1_2_22_86_1","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1038\/s41593-018-0242-x","article-title":"Microglia in Neurodegeneration","volume":"21","author":"Hickman S.","year":"2018","journal-title":"Nature Neuroscience"},{"issue":"1","key":"e_1_2_22_87_1","doi-asserted-by":"crossref","first-page":"T31","DOI":"10.1530\/JOE-13-0221","article-title":"Central Effects of GLP\u20101: New Opportunities for Treatments of Neurodegenerative Diseases","volume":"221","author":"Holscher C.","year":"2014","journal-title":"Journal of Endocrinology"},{"issue":"4","key":"e_1_2_22_88_1","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1080\/13543784.2020.1738383","article-title":"Brain Insulin Resistance: Role in Neurodegenerative Disease and Potential for Targeting","volume":"29","author":"Holscher C.","year":"2020","journal-title":"Expert Opinion on Investigational Drugs"},{"key":"e_1_2_22_89_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2024.109952","article-title":"Glucagon\u2010Like Peptide\u20101 Class Drugs Show Clear Protective Effects in Parkinson's and Alzheimer's Disease Clinical Trials: A Revolution in the Making","volume":"253","author":"H\u00f6lscher C.","year":"2024","journal-title":"Neuropharmacology"},{"issue":"9","key":"e_1_2_22_90_1","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1016\/j.neurobiolaging.2008.08.023","article-title":"New Roles for Insulin\u2010Like Hormones in Neuronal Signalling and Protection: New Hopes for Novel Treatments of Alzheimer's Disease","volume":"31","author":"H\u00f6lscher C.","year":"2010","journal-title":"Neurobiology of Aging"},{"issue":"1","key":"e_1_2_22_91_1","doi-asserted-by":"crossref","first-page":"5","DOI":"10.2337\/diabetes.53.1.5","article-title":"Epac: A New cAMP\u2010Binding Protein in Support of Glucagon\u2010Like Peptide\u20101 Receptor\u2010Mediated Signal Transduction in the Pancreatic Beta\u2010Cell","volume":"53","author":"Holz G. G.","year":"2004","journal-title":"Diabetes"},{"key":"e_1_2_22_92_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2026.115815","article-title":"Neurovascular Unit Dysfunction in Vascular Cognitive Impairment: Mechanisms, Biomarkers, and Translational Strategies","volume":"403","author":"Hoyer\u2010Kimura C.","year":"2026","journal-title":"Experimental Neurology"},{"issue":"1","key":"e_1_2_22_93_1","doi-asserted-by":"crossref","DOI":"10.1038\/s41392-021-00791-1","article-title":"The JAK\/STAT Signaling Pathway: From Bench to Clinic","volume":"6","author":"Hu X.","year":"2021","journal-title":"Signal Transduction and Targeted Therapy"},{"key":"e_1_2_22_94_1","doi-asserted-by":"crossref","first-page":"10401","DOI":"10.2147\/IJN.S479670","article-title":"Exenatide\u2010Modified Deferoxamine\u2010Based Nanoparticles Ameliorates Neurological Deficits in Parkinson's Disease Mice","volume":"19","author":"Huang Y.","year":"2024","journal-title":"International Journal of Nanomedicine"},{"issue":"9","key":"e_1_2_22_95_1","article-title":"Glucagon\u2010Like Peptide\u20101 Receptor Agonists in Neurodegenerative Diseases: A Comprehensive Review","volume":"17","author":"Ibrahim R.","year":"2025","journal-title":"Cureus"},{"issue":"4","key":"e_1_2_22_96_1","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1007\/s10555-024-10192-9","article-title":"The Effect of GLP\u20101R Agonists on the Medical Triad of Obesity, Diabetes, and Cancer","volume":"43","author":"Ibrahim S. S.","year":"2024","journal-title":"Cancer and Metastasis Reviews"},{"issue":"3","key":"e_1_2_22_97_1","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.jalz.2016.08.005","article-title":"Defining Imaging Biomarker Cut Points for Brain Aging and Alzheimer's Disease","volume":"13","author":"Jack C. R.","year":"2017","journal-title":"Alzheimers Dement"},{"issue":"1","key":"e_1_2_22_98_1","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20220654","article-title":"Chronic TREM2 Activation Exacerbates Abeta\u2010Associated Tau Seeding and Spreading","volume":"220","author":"Jain N.","year":"2023","journal-title":"Journal of Experimental Medicine"},{"issue":"3","key":"e_1_2_22_99_1","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1056\/NEJMoa2206038","article-title":"Tirzepatide Once Weekly for the Treatment of Obesity","volume":"387","author":"Jastreboff A. M.","year":"2022","journal-title":"New England Journal of Medicine"},{"issue":"4","key":"e_1_2_22_100_1","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1007\/s00213-023-06492-7","article-title":"Liraglutide Ameliorates Delirium\u2010Like Behaviors of Aged Mice Undergoing Cardiac Surgery by Mitigating Microglia Activation via Promoting Mitophagy","volume":"241","author":"Jia M.","year":"2024","journal-title":"Psychopharmacology"},{"key":"e_1_2_22_101_1","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2018.01168","article-title":"GLP\u20101 Improves Adipocyte Insulin Sensitivity Following Induction of Endoplasmic Reticulum Stress","volume":"9","author":"Jiang Y.","year":"2018","journal-title":"Frontiers in Pharmacology"},{"issue":"11","key":"e_1_2_22_102_1","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1111\/j.1463-1326.2011.01431.x","article-title":"GLP\u20101 Signals via ERK in Peripheral Nerve and Prevents Nerve Dysfunction in Diabetic Mice","volume":"13","author":"Jolivalt C. G.","year":"2011","journal-title":"Diabetes, Obesity & Metabolism"},{"issue":"5","key":"e_1_2_22_103_1","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.2337\/db14-1051","article-title":"PKA Enhances the Acute Insulin Response Leading to the Restoration of Glucose Control","volume":"64","author":"Kaihara K. A.","year":"2015","journal-title":"Diabetes"},{"issue":"2","key":"e_1_2_22_104_1","doi-asserted-by":"crossref","first-page":"S74","DOI":"10.1111\/j.1753-4887.2010.00352.x","article-title":"Vascular Basis for Brain Degeneration: Faltering Controls and Risk Factors for Dementia","volume":"68","author":"Kalaria R. N.","year":"2010","journal-title":"Nutrition Reviews"},{"issue":"7","key":"e_1_2_22_105_1","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25073812","article-title":"GLP\u20101 Receptor Agonists: A New Treatment in Parkinson's Disease","volume":"25","author":"Kalinderi K.","year":"2024","journal-title":"International Journal of Molecular Sciences"},{"key":"e_1_2_22_106_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2020.105028","article-title":"Microglia and Astrocyte Dysfunction in Parkinson's Disease","volume":"144","author":"Kam T. I.","year":"2020","journal-title":"Neurobiology of Disease"},{"key":"e_1_2_22_107_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.metabol.2023.155710","article-title":"Safety and Efficacy of the New, Oral, Small\u2010Molecule, GLP\u20101 Receptor Agonists Orforglipron and Danuglipron for the Treatment of Type 2 Diabetes and Obesity: Systematic Review and Meta\u2010Analysis of Randomized Controlled Trials","volume":"149","author":"Karakasis P.","year":"2023","journal-title":"Metabolism"},{"key":"e_1_2_22_108_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2024.102465","article-title":"Overview of Pro\u2010Inflammatory and Pro\u2010Survival Components in Neuroinflammatory Signalling and Neurodegeneration","volume":"100","author":"Kardam S.","year":"2024","journal-title":"Ageing Research Reviews"},{"issue":"7","key":"e_1_2_22_109_1","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1016\/j.cell.2017.05.018","article-title":"A Unique Microglia Type Associated With Restricting Development of Alzheimer's Disease","volume":"169","author":"Keren\u2010Shaul H.","year":"2017","journal-title":"Cell"},{"issue":"1","key":"e_1_2_22_110_1","doi-asserted-by":"crossref","DOI":"10.3390\/cimb47010008","article-title":"Mechanisms and Emerging Regulators of Neuroinflammation: Exploring New Therapeutic Strategies for Neurological Disorders","volume":"47","author":"Kim M. E.","year":"2024","journal-title":"Current Issues in Molecular Biology"},{"issue":"16","key":"e_1_2_22_111_1","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22168800","article-title":"Astrocytes Stimulate Microglial Proliferation and M2 Polarization In\u00a0Vitro Through Crosstalk Between Astrocytes and Microglia","volume":"22","author":"Kim S.","year":"2021","journal-title":"International Journal of Molecular Sciences"},{"key":"e_1_2_22_112_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2022.106550","article-title":"Glucagon\u2010Like Peptide\u20101 (GLP\u20101) Receptor Agonists and Neuroinflammation: Implications for Neurodegenerative Disease Treatment","volume":"186","author":"Kopp K. O.","year":"2022","journal-title":"Pharmacological Research"},{"issue":"3","key":"e_1_2_22_113_1","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.immuni.2017.08.008","article-title":"The TREM2\u2010APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases","volume":"47","author":"Krasemann S.","year":"2017","journal-title":"Immunity"},{"issue":"4","key":"e_1_2_22_114_1","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1152\/physrev.00032.2015","article-title":"Brain Insulin Resistance at the Crossroads of Metabolic and Cognitive Disorders in Humans","volume":"96","author":"Kullmann S.","year":"2016","journal-title":"Physiological Reviews"},{"issue":"1","key":"e_1_2_22_115_1","doi-asserted-by":"crossref","DOI":"10.1186\/s40035-020-00221-2","article-title":"Neuroinflammation in Neurodegenerative Disorders: The Roles of Microglia and Astrocytes","volume":"9","author":"Kwon H. S.","year":"2020","journal-title":"Translational Neurodegeneration"},{"issue":"1","key":"e_1_2_22_116_1","doi-asserted-by":"crossref","DOI":"10.1186\/s40478-023-01526-9","article-title":"Roles of Neuropathology\u2010Associated Reactive Astrocytes: A Systematic Review","volume":"11","author":"Lawrence J. M.","year":"2023","journal-title":"Acta Neuropathologica Communications"},{"issue":"11","key":"e_1_2_22_117_1","doi-asserted-by":"crossref","first-page":"2327","DOI":"10.1002\/alz.12610","article-title":"Role of Chronic Neuroinflammation in Neuroplasticity and Cognitive Function: A Hypothesis","volume":"18","author":"Lecca D.","year":"2022","journal-title":"Alzheimers Dement"},{"issue":"5","key":"e_1_2_22_118_1","doi-asserted-by":"crossref","first-page":"281","DOI":"10.14348\/molcells.2021.0060","article-title":"Distinct Features of Brain\u2010Resident Macrophages: Microglia and Non\u2010Parenchymal Brain Macrophages","volume":"44","author":"Lee E.","year":"2021","journal-title":"Molecules and Cells"},{"key":"e_1_2_22_119_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.cccb.2023.100199","article-title":"What Have Clinical Trials Taught Us About Brain Health","volume":"6","author":"Lee K.\u2010J.","year":"2024","journal-title":"Cerebral Circulation\u2010Cognition and Behavior"},{"key":"e_1_2_22_120_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113063","article-title":"Pimozide Inhibits the Growth of Breast Cancer Cells by Alleviating the Warburg Effect Through the P53 Signaling Pathway","volume":"150","author":"Li J.","year":"2022","journal-title":"Biomedicine & Pharmacotherapy"},{"issue":"1","key":"e_1_2_22_121_1","doi-asserted-by":"crossref","DOI":"10.1038\/s41392-023-01668-1","article-title":"Multifunctional Nanoparticle\u2010Mediated Combining Therapy for Human Diseases","volume":"9","author":"Li X.","year":"2024","journal-title":"Signal Transduction and Targeted Therapy"},{"issue":"14","key":"e_1_2_22_122_1","doi-asserted-by":"crossref","DOI":"10.3390\/cells15141301","article-title":"Orforglipron, a Small\u2010Molecule Glucagon\u2010Like Peptide\u20101 Receptor Agonist (GLP\u20101RA), Has Neuroprotective and Anti\u2010inflammatory Effects","volume":"15","author":"Li Y.","year":"2026","journal-title":"Cells"},{"issue":"2","key":"e_1_2_22_123_1","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1152\/physiolgenomics.00242.2007","article-title":"Altered Neuronal Gene Expression in Brain Regions Differentially Affected by Alzheimer's Disease: A Reference Data Set","volume":"33","author":"Liang W. S.","year":"2008","journal-title":"Physiological Genomics"},{"issue":"7638","key":"e_1_2_22_124_1","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/nature21029","article-title":"Neurotoxic Reactive Astrocytes Are Induced by Activated Microglia","volume":"541","author":"Liddelow S. A.","year":"2017","journal-title":"Nature"},{"key":"e_1_2_22_125_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2022.109653","article-title":"The GLP\u20101 Receptor Agonist Exenatide Ameliorates Neuroinflammation, Locomotor Activity, and Anxiety\u2010Like Behavior in Mice With Diet\u2010Induced Obesity Through the Modulation of Microglial M2 Polarization and Downregulation of SR\u2010A4","volume":"115","author":"Lin M.\u2010H.","year":"2023","journal-title":"International Immunopharmacology"},{"issue":"14","key":"e_1_2_22_126_1","doi-asserted-by":"crossref","first-page":"2162","DOI":"10.4161\/cc.29584","article-title":"Phosphorylation of Akt at the C\u2010Terminal Tail Triggers Akt Activation","volume":"13","author":"Liu P.","year":"2014","journal-title":"Cell Cycle"},{"key":"e_1_2_22_127_1","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.neuroscience.2015.06.054","article-title":"Neuroprotective Effects of Lixisenatide and Liraglutide in the 1\u2010Methyl\u20104\u2010Phenyl\u20101,2,3,6\u2010Tetrahydropyridine Mouse Model of Parkinson's Disease","volume":"303","author":"Liu W.","year":"2015","journal-title":"Neuroscience"},{"issue":"1","key":"e_1_2_22_128_1","doi-asserted-by":"crossref","DOI":"10.1038\/s41398-020-01155-z","article-title":"PET Evaluation of Light\u2010Induced Modulation of Microglial Activation and GLP\u20101R Expression in Depressive Rats","volume":"11","author":"Liu Y.","year":"2021","journal-title":"Translational Psychiatry"},{"key":"e_1_2_22_129_1","doi-asserted-by":"crossref","first-page":"10383","DOI":"10.2147\/DDDT.S559919","article-title":"The Clinical Application of GLP\u20101RAs and GLP\u20101\/GIP Dual Receptor Agonists Based on Pharmacological Mechanisms: A Review","volume":"19","author":"Liu Z.","year":"2025","journal-title":"Drug Design, Development and Therapy"},{"issue":"10452","key":"e_1_2_22_130_1","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/S0140-6736(24)01296-0","article-title":"Dementia Prevention, Intervention, and Care: 2024 Report of the Lancet Standing Commission","volume":"404","author":"Livingston G.","year":"2024","journal-title":"Lancet"},{"issue":"4","key":"e_1_2_22_131_1","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1124\/molpharm.121.000270","article-title":"Acylation of the Incretin Peptide Exendin\u20104 Directly Impacts Glucagon\u2010Like Peptide\u20101 Receptor Signaling and Trafficking","volume":"100","author":"Lucey M.","year":"2021","journal-title":"Molecular Pharmacology"},{"issue":"21","key":"e_1_2_22_132_1","doi-asserted-by":"crossref","first-page":"3711","DOI":"10.1007\/s00018-010-0398-3","article-title":"Differentiating Effects of the Glucagon\u2010Like Peptide\u20101 Analogue Exendin\u20104 in a Human Neuronal Cell Model","volume":"67","author":"Luciani P.","year":"2010","journal-title":"Cellular and Molecular Life Sciences"},{"issue":"8","key":"e_1_2_22_133_1","doi-asserted-by":"crossref","DOI":"10.1002\/brb3.2231","article-title":"The GLP\u20101\/GIP Dual\u2010Receptor Agonist DA5\u2010CH Inhibits the NF\u2010\u03baB Inflammatory Pathway in the MPTP Mouse Model of Parkinson's Disease More Effectively Than the GLP\u20101 Single\u2010Receptor Agonist NLY01","volume":"11","author":"Lv M.","year":"2021","journal-title":"Brain and Behavior"},{"key":"e_1_2_22_134_1","article-title":"Microglial Activation of GLP\u20101R Signaling in Neuropathic Pain Promotes Gene Expression Adaption Involved in Inflammatory Responses","volume":"2021","author":"Ma L.","year":"2021","journal-title":"Neural Plasticity"},{"issue":"10","key":"e_1_2_22_135_1","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1111\/cns.13694","article-title":"Spinal Microglial \u03b2\u2010Endorphin Signaling Mediates IL\u201010 and Exenatide\u2010Induced Inhibition of Synaptic Plasticity in Neuropathic Pain","volume":"27","author":"Ma L.","year":"2021","journal-title":"CNS Neuroscience & Therapeutics"},{"issue":"4","key":"e_1_2_22_136_1","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.beem.2009.03.008","article-title":"Exenatide and Liraglutide: Different Approaches to Develop GLP\u20101 Receptor Agonists (Incretin Mimetics)\u2014Preclinical and Clinical Results","volume":"23","author":"Madsbad S.","year":"2009","journal-title":"Best Practice & Research. Clinical Endocrinology & Metabolism"},{"issue":"1","key":"e_1_2_22_137_1","doi-asserted-by":"crossref","DOI":"10.3390\/ph18010104","article-title":"Targeting Cytokine\u2010Mediated Inflammation in Brain Disorders: Developing New Treatment Strategies","volume":"18","author":"Mallick R.","year":"2025","journal-title":"Pharmaceuticals (Basel)"},{"issue":"4","key":"e_1_2_22_138_1","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1056\/NEJMoa1603827","article-title":"Liraglutide and Cardiovascular Outcomes in Type 2 Diabetes","volume":"375","author":"Marso S. P.","year":"2016","journal-title":"New England Journal of Medicine"},{"issue":"2","key":"e_1_2_22_139_1","doi-asserted-by":"crossref","first-page":"409","DOI":"10.3233\/JAD-141572","article-title":"Temporal Changes of CD68 and Alpha7 Nicotinic Acetylcholine Receptor Expression in Microglia in Alzheimer's Disease\u2010Like Mouse Models","volume":"44","author":"Matsumura A.","year":"2015","journal-title":"Journal of Alzheimer's Disease"},{"issue":"2","key":"e_1_2_22_140_1","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/nrn.2017.156","article-title":"Intermittent Metabolic Switching, Neuroplasticity and Brain Health","volume":"19","author":"Mattson M. P.","year":"2018","journal-title":"Nature Reviews. Neuroscience"},{"issue":"8","key":"e_1_2_22_141_1","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25084470","article-title":"Understanding Functional Neurological Disorder: Recent Insights and Diagnostic Challenges","volume":"25","author":"Mavroudis I.","year":"2024","journal-title":"International Journal of Molecular Sciences"},{"issue":"1","key":"e_1_2_22_142_1","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S1474-4422(23)00378-2","article-title":"Safety, Tolerability, and Efficacy of NLY01 in Early Untreated Parkinson's Disease: A Randomised, Double\u2010Blind, Placebo\u2010Controlled Trial","volume":"23","author":"McGarry A.","year":"2024","journal-title":"Lancet Neurology"},{"issue":"1","key":"e_1_2_22_143_1","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19010318","article-title":"Microglia and Aging: The Role of the TREM2\u2010DAP12 and CX3CL1\u2010CX3CR1 Axes","volume":"19","author":"Mecca C.","year":"2018","journal-title":"International Journal of Molecular Sciences"},{"issue":"13","key":"e_1_2_22_144_1","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1056\/NEJMoa2312323","article-title":"Trial of Lixisenatide in Early Parkinson's Disease","volume":"390","author":"Meissner W. G.","year":"2024","journal-title":"New England Journal of Medicine"},{"issue":"1","key":"e_1_2_22_145_1","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/s41593-020-00756-7","article-title":"Microglial Gi\u2010Dependent Dynamics Regulate Brain Network Hyperexcitability","volume":"24","author":"Merlini M.","year":"2021","journal-title":"Nature Neuroscience"},{"key":"e_1_2_22_146_1","doi-asserted-by":"crossref","first-page":"3509","DOI":"10.2147\/DDDT.S506957","article-title":"A Comprehensive Review on the Pharmacokinetics and Drug\u2212Drug Interactions of Approved GLP\u20101 Receptor Agonists and a Dual GLP\u20101\/GIP Receptor Agonist","volume":"19","author":"Min J. S.","year":"2025","journal-title":"Drug Design, Development and Therapy"},{"key":"e_1_2_22_147_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2024.176403","article-title":"Ruxolitinib Attenuates Microglial Inflammatory Response by Inhibiting NF\u2010kappaB\/MAPK Signaling Pathway","volume":"968","author":"Min J.","year":"2024","journal-title":"European Journal of Pharmacology"},{"issue":"20","key":"e_1_2_22_148_1","doi-asserted-by":"crossref","DOI":"10.3390\/ijms252010951","article-title":"Microglia Signatures: A Cause or Consequence of Microglia\u2010Related Brain Disorders","volume":"25","author":"Mirarchi A.","year":"2024","journal-title":"International Journal of Molecular Sciences"},{"issue":"1","key":"e_1_2_22_149_1","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1111\/nyas.12807","article-title":"Impact of Diabetes on Cognitive Function and Brain Structure","volume":"1353","author":"Moheet A.","year":"2015","journal-title":"Annals of the New York Academy of Sciences"},{"issue":"5","key":"e_1_2_22_150_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.diabet.2023.101470","article-title":"GLP\u20101 Receptor Agonists Effect on Cognitive Function in Patients With and Without Type 2 Diabetes","volume":"49","author":"Monney M.","year":"2023","journal-title":"Diabetes & Metabolism"},{"issue":"7806","key":"e_1_2_22_151_1","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1038\/s41586-020-2247-3","article-title":"APOE4 Leads to Blood\u2010Brain Barrier Dysfunction Predicting Cognitive Decline","volume":"581","author":"Montagne A.","year":"2020","journal-title":"Nature"},{"issue":"13","key":"e_1_2_22_152_1","doi-asserted-by":"crossref","DOI":"10.3390\/cells11132023","article-title":"GLP\u20101 Receptor Agonists in Neurodegeneration: Neurovascular Unit in the Spotlight","volume":"11","author":"Monti G.","year":"2022","journal-title":"Cells"},{"key":"e_1_2_22_153_1","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.molmet.2019.09.010","article-title":"Glucagon\u2010Like Peptide 1 (GLP\u20101)","volume":"30","author":"Muller T. D.","year":"2019","journal-title":"Molecular Metabolism"},{"issue":"8","key":"e_1_2_22_154_1","doi-asserted-by":"crossref","first-page":"741","DOI":"10.2174\/1567205016666190913155950","article-title":"A Pilot Study of Exenatide Actions in Alzheimer's Disease","volume":"16","author":"Mullins R. J.","year":"2019","journal-title":"Current Alzheimer Research"},{"issue":"1","key":"e_1_2_22_155_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.33160\/yam.2024.02.001","article-title":"Roles of Microglia in Neurodegenerative Diseases","volume":"67","author":"Nakaso K.","year":"2024","journal-title":"Yonago Acta Medica"},{"issue":"3","key":"e_1_2_22_156_1","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1016\/j.neuroscience.2008.06.046","article-title":"Microglial Clearance Function in Health and Disease","volume":"158","author":"Napoli I.","year":"2009","journal-title":"Neuroscience"},{"key":"e_1_2_22_157_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2020.101102","article-title":"GLP\u20101 Receptor Agonists in the Treatment of Type 2 Diabetes\u2013State\u2010Of\u2010The\u2010Art","volume":"46","author":"Nauck M. A.","year":"2021","journal-title":"Molecular Metabolism"},{"issue":"7","key":"e_1_2_22_158_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.108047","article-title":"Fractalkine\u2010Dependent Microglial Pruning of Viable Oligodendrocyte Progenitor Cells Regulates Myelination","volume":"32","author":"Nemes\u2010Baran A. D.","year":"2020","journal-title":"Cell Reports"},{"issue":"2","key":"e_1_2_22_159_1","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1093\/brain\/awn109","article-title":"Debris Clearance by Microglia: An Essential Link Between Degeneration and Regeneration","volume":"132","author":"Neumann H.","year":"2009","journal-title":"Brain"},{"issue":"10","key":"e_1_2_22_160_1","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1002\/acn3.50877","article-title":"11C\u2010PK11195 PET Imaging and White Matter Changes in Parkinson's Disease Dementia","volume":"6","author":"Nicastro N.","year":"2019","journal-title":"Annals of Clinical and Translational Neurology"},{"issue":"1","key":"e_1_2_22_161_1","doi-asserted-by":"crossref","DOI":"10.1186\/s13024-025-00867-4","article-title":"Biomarkers and Therapeutic Strategies Targeting Microglia in Neurodegenerative Diseases: Current Status and Future Directions","volume":"20","author":"Noh M.\u2010Y.","year":"2025","journal-title":"Molecular Neurodegeneration"},{"issue":"1","key":"e_1_2_22_162_1","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1038\/s41380-022-01792-4","article-title":"Incretin and Insulin Signaling as Novel Therapeutic Targets for Alzheimer's and Parkinson's Disease","volume":"28","author":"Nowell J.","year":"2023","journal-title":"Molecular Psychiatry"},{"issue":"1","key":"e_1_2_22_163_1","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1007\/s00259-020-05166-2","article-title":"Cellular Sources of TSPO Expression in Healthy and Diseased Brain","volume":"49","author":"Nutma E.","year":"2021","journal-title":"European Journal of Nuclear Medicine and Molecular Imaging"},{"key":"e_1_2_22_164_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.regpep.2014.04.003","article-title":"Exendin\u20104 Promotes the Membrane Trafficking of the AMPA Receptor GluR1 Subunit and ADAM10 in the Mouse Neocortex","volume":"190","author":"Ohtake N.","year":"2014","journal-title":"Regulatory Peptides"},{"issue":"1","key":"e_1_2_22_165_1","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1038\/s41467-018-02926-5","article-title":"A Transcriptomic Atlas of Aged Human Microglia","volume":"9","author":"Olah M.","year":"2018","journal-title":"Nature Communications"},{"issue":"4","key":"e_1_2_22_166_1","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1111\/bph.13139","article-title":"Microglial M1\/M2 Polarization and Metabolic States","volume":"173","author":"Orihuela R.","year":"2016","journal-title":"British Journal of Pharmacology"},{"issue":"2","key":"e_1_2_22_167_1","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22020860","article-title":"Liraglutide Has Anti\u2010Inflammatory and Anti\u2010Amyloid Properties in Streptozotocin\u2010Induced and 5xFAD Mouse Models of Alzheimer's Disease","volume":"22","author":"Paladugu L.","year":"2021","journal-title":"International Journal of Molecular Sciences"},{"issue":"1","key":"e_1_2_22_168_1","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1186\/s40478-021-01180-z","article-title":"Blocking Microglial Activation of Reactive Astrocytes Is Neuroprotective in Models of Alzheimer's Disease","volume":"9","author":"Park J. S.","year":"2021","journal-title":"Acta Neuropathologica Communications"},{"issue":"12","key":"e_1_2_22_169_1","article-title":"The Role of Glucagon\u2010Like Peptide\u20101 Receptor Agonists in Alzheimer's and Parkinson's Disease: A Literature Review of Clinical Trials","volume":"15","author":"Pilsniak J.","year":"2025","journal-title":"Life (Basel)"},{"issue":"4","key":"e_1_2_22_170_1","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1002\/glia.24318","article-title":"Alzheimer's Disease\u2010Associated R47H TREM2 Increases, but Wild\u2010Type TREM2 Decreases, Microglial Phagocytosis of Synaptosomes and Neuronal Loss","volume":"71","author":"Popescu A. S.","year":"2023","journal-title":"Glia"},{"issue":"1","key":"e_1_2_22_171_1","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1146\/annurev-immunol-093019-110159","article-title":"Microglia and Central Nervous System\u2013Associated Macrophages\u2014From Origin to Disease Modulation","volume":"39","author":"Prinz M.","year":"2021","journal-title":"Annual Review of Immunology"},{"issue":"12","key":"e_1_2_22_172_1","doi-asserted-by":"crossref","first-page":"4197","DOI":"10.2337\/db14-0153","article-title":"GABA Promotes Human Beta\u2010Cell Proliferation and Modulates Glucose Homeostasis","volume":"63","author":"Purwana I.","year":"2014","journal-title":"Diabetes"},{"issue":"1","key":"e_1_2_22_173_1","doi-asserted-by":"crossref","DOI":"10.1038\/s41531-023-00449-5","article-title":"A Systematic Review and Meta\u2010Analysis of Inflammatory Biomarkers in Parkinson's Disease","volume":"9","author":"Qu Y.","year":"2023","journal-title":"NPJ Parkinsons Disease"},{"issue":"1","key":"e_1_2_22_174_1","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/9982954","article-title":"Inflammation and Alzheimer's Disease: Mechanisms and Therapeutic Implications by Natural Products","volume":"2021","author":"Rather M. A.","year":"2021","journal-title":"Mediators of Inflammation"},{"key":"e_1_2_22_175_1","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2022.970925","article-title":"The Neuroprotective Effects of Glucagon\u2010Like Peptide 1 in Alzheimer's and Parkinson's Disease: An In\u2010Depth Review","volume":"16","author":"Reich N.","year":"2022","journal-title":"Frontiers in Neuroscience"},{"issue":"4","key":"e_1_2_22_176_1","doi-asserted-by":"crossref","DOI":"10.1080\/21688370.2023.2292461","article-title":"Brain Uptake Pharmacokinetics of Albiglutide, Dulaglutide, Tirzepatide, and DA5\u2010CH in the Search for New Treatments of Alzheimer's and Parkinson's Diseases","volume":"12","author":"Rhea E. M.","year":"2024","journal-title":"Tissue Barriers"},{"key":"e_1_2_22_177_1","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2018.00672","article-title":"Pleiotropic Effects of GLP\u20101 and Analogs on Cell Signaling, Metabolism, and Function","volume":"9","author":"Rowlands J.","year":"2018","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"5","key":"e_1_2_22_178_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.neurot.2025.e00712","article-title":"From Metabolism to Mind: The Expanding Role of the GLP\u20101 Receptor in Neurotherapeutics","volume":"22","author":"Roy A.","year":"2025","journal-title":"Neurotherapeutics"},{"key":"e_1_2_22_179_1","doi-asserted-by":"crossref","DOI":"10.3389\/fnsyn.2022.833449","article-title":"AMPA Receptor Function in Hypothalamic Synapses","volume":"14","author":"Royo M.","year":"2022","journal-title":"Frontiers in Synaptic Neuroscience"},{"key":"e_1_2_22_180_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2020.113506","article-title":"TREM2 Overexpression Rescues Cognitive Deficits in APP\/PS1 Transgenic Mice by Reducing Neuroinflammation via the JAK\/STAT\/SOCS Signaling Pathway","volume":"336","author":"Ruganzu J. B.","year":"2021","journal-title":"Experimental Neurology"},{"issue":"1","key":"e_1_2_22_181_1","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-023-42096-7","article-title":"Species\u2010Specific Metabolic Reprogramming in Human and Mouse Microglia During Inflammatory Pathway Induction","volume":"14","author":"Sabogal\u2010Guaqueta A. M.","year":"2023","journal-title":"Nature Communications"},{"key":"e_1_2_22_182_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2022.109647","article-title":"Semaglutide, a Novel Glucagon\u2010Like Peptide\u20101 Agonist, Amends Experimental Autoimmune Encephalomyelitis\u2010Induced Multiple Sclerosis in Mice: Involvement of the PI3K\/Akt\/GSK\u20103beta Pathway","volume":"115","author":"Sadek M. A.","year":"2023","journal-title":"International Immunopharmacology"},{"issue":"5","key":"e_1_2_22_183_1","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1111\/j.1476-5381.2012.01971.x","article-title":"Neuroprotective and Neurotrophic Actions of Glucagon\u2010Like Peptide\u20101: An Emerging Opportunity to Treat Neurodegenerative and Cerebrovascular Disorders","volume":"166","author":"Salcedo I.","year":"2012","journal-title":"British Journal of Pharmacology"},{"issue":"12","key":"e_1_2_22_184_1","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1002\/mds.27547","article-title":"Glial GLP1R: A Novel Neuroprotector","volume":"33","author":"Schonhoff A. M.","year":"2018","journal-title":"Movement Disorders"},{"issue":"4","key":"e_1_2_22_185_1","doi-asserted-by":"crossref","DOI":"10.3390\/antiox14040457","article-title":"Signaling Pathways in Oxidative Stress\u2010Induced Neurodegenerative Diseases: A Review of Phytochemical Therapeutic Interventions","volume":"14","author":"Sebghatollahi Z.","year":"2025","journal-title":"Antioxidants (Basel)"},{"issue":"10","key":"e_1_2_22_186_1","doi-asserted-by":"crossref","first-page":"4473","DOI":"10.1172\/JCI75276","article-title":"The Arcuate Nucleus Mediates GLP\u20101 Receptor Agonist Liraglutide\u2010Dependent Weight Loss","volume":"124","author":"Secher A.","year":"2014","journal-title":"Journal of Clinical Investigation"},{"issue":"7","key":"e_1_2_22_187_1","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1080\/00207454.2016.1212854","article-title":"Neuroinflammation Pathways: A General Review","volume":"127","author":"Shabab T.","year":"2017","journal-title":"International Journal of Neuroscience"},{"issue":"12","key":"e_1_2_22_188_1","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1038\/s41423-025-01368-6","article-title":"Microglia Across Evolution: From Conserved Origins to Functional Divergence","volume":"22","author":"Shimizu T.","year":"2025","journal-title":"Cellular & Molecular Immunology"},{"issue":"4","key":"e_1_2_22_189_1","doi-asserted-by":"crossref","DOI":"10.3390\/antiox14040396","article-title":"Evaluation of Additive Neuroprotective Effect of Combination Therapy for Parkinson's Disease Using In\u00a0Vitro Models","volume":"14","author":"Shtilbans A.","year":"2025","journal-title":"Antioxidants (Basel)"},{"issue":"4","key":"e_1_2_22_190_1","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.neuron.2006.01.022","article-title":"Bone Marrow\u2010Derived Microglia Play a Critical Role in Restricting Senile Plaque Formation in Alzheimer's Disease","volume":"49","author":"Simard A. R.","year":"2006","journal-title":"Neuron"},{"issue":"1","key":"e_1_2_22_191_1","doi-asserted-by":"crossref","DOI":"10.1186\/s13578-022-00914-3","article-title":"Activation of Arcuate Nucleus Glucagon\u2010Like Peptide\u20101 Receptor\u2010Expressing Neurons Suppresses Food Intake","volume":"12","author":"Singh I.","year":"2022","journal-title":"Cell & Bioscience"},{"issue":"2","key":"e_1_2_22_192_1","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.jalz.2017.06.2637","article-title":"Obesity Trajectories and Risk of Dementia: 28 Years of Follow\u2010Up in the Whitehall II Study","volume":"14","author":"Singh\u2010Manoux A.","year":"2018","journal-title":"Alzheimers Dement"},{"issue":"2","key":"e_1_2_22_193_1","doi-asserted-by":"crossref","first-page":"S5","DOI":"10.3233\/JAD-2011-110899","article-title":"Metabolic Reserve as a Determinant of Cognitive Aging","volume":"30","author":"Stranahan A. M.","year":"2012","journal-title":"Journal of Alzheimer's Disease"},{"issue":"1","key":"e_1_2_22_194_1","doi-asserted-by":"crossref","DOI":"10.1186\/s12974-020-01845-x","article-title":"The CD200\/CD200R Signaling Pathway Contributes to Spontaneous Functional Recovery by Enhancing Synaptic Plasticity After Stroke","volume":"17","author":"Sun H.","year":"2020","journal-title":"Journal of Neuroinflammation"},{"issue":"2","key":"e_1_2_22_195_1","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1007\/s12035-014-9070-5","article-title":"Differential Roles of M1 and M2 Microglia in Neurodegenerative Diseases","volume":"53","author":"Tang Y.","year":"2016","journal-title":"Molecular Neurobiology"},{"issue":"1","key":"e_1_2_22_196_1","doi-asserted-by":"crossref","DOI":"10.3390\/receptors4010002","article-title":"Exploring the Role of GLP\u20101 Receptor Agonists in Alzheimer's Disease: A Review of Preclinical and Clinical Evidence","volume":"4","author":"Teixeira L. C. R.","year":"2025","journal-title":"Receptor"},{"issue":"17","key":"e_1_2_22_197_1","doi-asserted-by":"crossref","DOI":"10.3390\/ijms27177855","article-title":"Combination GLP\u20101RA and Low\u2010Dose IL\u20102 Modulates Peripheral Immune Activation and Attenuates CNS Inflammatory Transcript Signatures In\u00a0Vivo","volume":"27","author":"Thome A. D.","year":"2026","journal-title":"International Journal of Molecular Sciences"},{"issue":"9","key":"e_1_2_22_198_1","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25094972","article-title":"A Systematic Review of Semaglutide's Influence on Cognitive Function in Preclinical Animal Models and Cell\u2010Line Studies","volume":"25","author":"Tipa R. O.","year":"2024","journal-title":"International Journal of Molecular Sciences"},{"issue":"1","key":"e_1_2_22_199_1","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1146\/annurev-genet-022223-093643","article-title":"Microglial Transcriptional Signatures in the Central Nervous System: Toward a Future of Unraveling Their Function in Health and Disease","volume":"57","author":"Vecchiarelli H. A.","year":"2023","journal-title":"Annual Review of Genetics"},{"issue":"1","key":"e_1_2_22_200_1","doi-asserted-by":"crossref","DOI":"10.1186\/s12933-022-01686-3","article-title":"Protection Against Stroke With Glucagon\u2010Like Peptide\u20101 Receptor Agonists: A Comprehensive Review of Potential Mechanisms","volume":"21","author":"Verg\u00e8s B.","year":"2022","journal-title":"Cardiovascular Diabetology"},{"key":"e_1_2_22_201_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2024.176936","article-title":"Beyond Insulin: The Intriguing Role of GLP\u20101 in Parkinson's Disease","volume":"982","author":"Verma A.","year":"2024","journal-title":"European Journal of Pharmacology"},{"issue":"5","key":"e_1_2_22_202_1","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2020-047993","article-title":"Exenatide Once Weekly Over 2 Years as a Potential Disease\u2010Modifying Treatment for Parkinson's Disease: Protocol for a Multicentre, Randomised, Double Blind, Parallel Group, Placebo Controlled, Phase 3 Trial: The \u2018Exenatide\u2010PD3\u2019 Study","volume":"11","author":"Vijiaratnam N.","year":"2021","journal-title":"BMJ Open"},{"issue":"10479","key":"e_1_2_22_203_1","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/S0140-6736(24)02808-3","article-title":"Exenatide Once a Week Versus Placebo as a Potential Disease\u2010Modifying Treatment for People With Parkinson's Disease in the UK: A Phase 3, Multicentre, Double\u2010Blind, Parallel\u2010Group, Randomised, Placebo\u2010Controlled Trial","volume":"405","author":"Vijiaratnam N.","year":"2025","journal-title":"Lancet"},{"key":"e_1_2_22_204_1","first-page":"225","article-title":"Imaging Neurodegeneration and Neuroinflammation in Alzheimer's Disease","volume":"14","author":"Villemagne V.","year":"2018","journal-title":"Nature Reviews. Neurology"},{"key":"e_1_2_22_205_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.mam.2020.100889","article-title":"The NLRP3 Inflammasome: Mechanism of Action, Role in Disease and Therapies","volume":"76","author":"Wang L.","year":"2020","journal-title":"Molecular Aspects of Medicine"},{"issue":"2","key":"e_1_2_22_206_1","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1021\/acsptsci.1c00013","article-title":"Sustained Release GLP\u20101 Agonist PT320 Delays Disease Progression in a Mouse Model of Parkinson's Disease","volume":"4","author":"Wang V.","year":"2021","journal-title":"ACS Pharmacology & Translational Science"},{"issue":"12","key":"e_1_2_22_207_1","doi-asserted-by":"crossref","first-page":"8661","DOI":"10.1002\/alz.14313","article-title":"Associations of Semaglutide With First\u2010Time Diagnosis of Alzheimer's Disease in Patients With Type 2 Diabetes: Target Trial Emulation Using Nationwide Real\u2010World Data in the US","volume":"20","author":"Wang W.","year":"2024","journal-title":"Alzheimers Dement"},{"key":"e_1_2_22_208_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2024.110890","article-title":"Fisetin Suppresses Chondrocyte Senescence and Attenuates Osteoarthritis Progression by Targeting Sirtuin 6","volume":"390","author":"Wang X.","year":"2024","journal-title":"Chemico\u2010Biological Interactions"},{"issue":"6","key":"e_1_2_22_209_1","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/j.cell.2015.01.049","article-title":"TREM2 Lipid Sensing Sustains the Microglial Response in an Alzheimer's Disease Model","volume":"160","author":"Wang Y.","year":"2015","journal-title":"Cell"},{"key":"e_1_2_22_210_1","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.neuroscience.2024.11.022","article-title":"Semaglutide Promotes the Transition of Microglia From M1 to M2 Type to Reduce Brain Inflammation in APP\/PS1\/Tau Mice","volume":"563","author":"Wang Z. J.","year":"2024","journal-title":"Neuroscience"},{"key":"e_1_2_22_211_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2023.109716","article-title":"Semaglutide Ameliorates Cognition and Glucose Metabolism Dysfunction in the 3xTg Mouse Model of Alzheimer's Disease via the GLP\u20101R\/SIRT1\/GLUT4 Pathway","volume":"240","author":"Wang Z. J.","year":"2023","journal-title":"Neuropharmacology"},{"issue":"11","key":"e_1_2_22_212_1","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1016\/j.biopsych.2012.05.029","article-title":"A Randomized Trial to Examine the Effect of Mifepristone on Neuropsychological Performance and Mood in Patients With Bipolar Depression","volume":"72","author":"Watson S.","year":"2012","journal-title":"Biological Psychiatry"},{"issue":"4","key":"e_1_2_22_213_1","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1007\/s40120-025-00724-y","article-title":"Are Glucagon\u2010Like Peptide\u20101 (GLP\u20101) Receptor Agonists Central Nervous System (CNS) Penetrant: A Narrative Review","volume":"14","author":"West J.","year":"2025","journal-title":"Neurology and Therapy"},{"issue":"4","key":"e_1_2_22_214_1","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1007\/s40120-025-00724-y","article-title":"Are Glucagon\u2010Like Peptide\u20101 (GLP\u20101) Receptor Agonists Central Nervous System (CNS) Penetrant: A Narrative Review","volume":"14","author":"West J.","year":"2025","journal-title":"Neurology and Therapy"},{"issue":"1","key":"e_1_2_22_215_1","doi-asserted-by":"crossref","DOI":"10.1186\/s12933-025-02608-9","article-title":"Glucagon\u2010Like Peptide\u20101 Receptor Agonists (GLP\u20101RAs) and Cardiometabolic Protection: Historical Development and Future Challenges","volume":"24","author":"Westermeier F.","year":"2025","journal-title":"Cardiovascular Diabetology"},{"issue":"4","key":"e_1_2_22_216_1","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1111\/bph.15535","article-title":"The Diverse Effects of Brain Glucagon\u2010Like Peptide 1 Receptors on Ingestive Behaviour","volume":"179","author":"Williams D. L.","year":"2022","journal-title":"British Journal of Pharmacology"},{"issue":"5","key":"e_1_2_22_217_1","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1523\/JNEUROSCI.22-05-01763.2002","article-title":"Blockade of Microglial Activation Is Neuroprotective in the 1\u2010Methyl\u20104\u2010Phenyl\u20101,2,3,6\u2010Tetrahydropyridine Mouse Model of Parkinson Disease","volume":"22","author":"Wu D. C.","year":"2002","journal-title":"Journal of Neuroscience"},{"key":"e_1_2_22_218_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2021.114578","article-title":"GLP\u20101 Improves the Neuronal Supportive Ability of Astrocytes in Alzheimer's Disease by Regulating Mitochondrial Dysfunction via the cAMP\/PKA Pathway","volume":"188","author":"Xie Y.","year":"2021","journal-title":"Biochemical Pharmacology"},{"issue":"9","key":"e_1_2_22_219_1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1012168","article-title":"Microglia and Macrophages Alterations in the CNS During Acute SIV Infection: A Single\u2010Cell Analysis in rhesus Macaques","volume":"20","author":"Xu X.","year":"2024","journal-title":"PLoS Pathogens"},{"issue":"18","key":"e_1_2_22_220_1","doi-asserted-by":"crossref","first-page":"2237","DOI":"10.1001\/jama.292.18.2237","article-title":"The Metabolic Syndrome, Inflammation, and Risk of Cognitive Decline","volume":"292","author":"Yaffe K.","year":"2004","journal-title":"JAMA"},{"issue":"1","key":"e_1_2_22_221_1","doi-asserted-by":"crossref","DOI":"10.1186\/s12885-024-12131-x","article-title":"Knockdown of NCAPD3 Inhibits the Tumorigenesis of Non\u2010small Cell Lung Cancer by Regulation of the PI3K\/Akt Pathway","volume":"24","author":"Yang F.","year":"2024","journal-title":"BMC Cancer"},{"key":"e_1_2_22_222_1","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2026.1839620","article-title":"GLP\u20101 Receptor Agonists in Neurological Diseases: Mechanisms and Therapeutic Prospects From Metabolism to Neuroprotection","volume":"17","author":"Yang M.","year":"2026","journal-title":"Frontiers in Immunology"},{"key":"e_1_2_22_223_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2021.105290","article-title":"Microglia Reprogram Metabolic Profiles for Phenotype and Function Changes in Central Nervous System","volume":"152","author":"Yang S.","year":"2021","journal-title":"Neurobiology of Disease"},{"issue":"5","key":"e_1_2_22_224_1","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1080\/14728222.2022.2079492","article-title":"Therapeutic Application of GLP\u20101 and GIP Receptor Agonists in Parkinson's Disease","volume":"26","author":"Yang X.","year":"2022","journal-title":"Expert Opinion on Therapeutic Targets"},{"issue":"6","key":"e_1_2_22_225_1","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/j.molmed.2017.03.008","article-title":"TREM2, Microglia, and Neurodegenerative Diseases","volume":"23","author":"Yeh F. L.","year":"2017","journal-title":"Trends in Molecular Medicine"},{"key":"e_1_2_22_226_1","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.ejphar.2017.06.029","article-title":"A Novel GLP\u20101\/GIP Dual Agonist Is More Effective Than Liraglutide in Reducing Inflammation and Enhancing GDNF Release in the MPTP Mouse Model of Parkinson's Disease","volume":"812","author":"Yuan Z.","year":"2017","journal-title":"European Journal of Pharmacology"},{"issue":"7","key":"e_1_2_22_227_1","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1038\/s41591-018-0051-5","article-title":"Block of A1 Astrocyte Conversion by Microglia Is Neuroprotective in Models of Parkinson's Disease","volume":"24","author":"Yun S. P.","year":"2018","journal-title":"Nature Medicine"},{"key":"e_1_2_22_228_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.curpro.2025.100014","article-title":"Incretin Hormones: Mechanisms, Therapeutic Implications, and Future Directions in Glucose Regulation and Diabetes Management","volume":"22","author":"Zargar A. A.","year":"2025","journal-title":"Current Proteomics"},{"issue":"2","key":"e_1_2_22_229_1","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1177\/13872877251329439","article-title":"Semaglutide Improves Cognitive Function and Neuroinflammation in APP\/PS1 Transgenic Mice by Activating AMPK and Inhibiting TLR4\/NF\u2010KappaB Pathway","volume":"105","author":"Zhai Y.","year":"2025","journal-title":"Journal of Alzheimer's Disease"},{"issue":"11","key":"e_1_2_22_230_1","doi-asserted-by":"crossref","first-page":"243","DOI":"10.2147\/NDT.S75546","article-title":"Neuroinflammation in Alzheimer's Disease","volume":"30","author":"Zhang F.","year":"2015","journal-title":"Neuropsychiatric Disease and Treatment"},{"issue":"1","key":"e_1_2_22_231_1","doi-asserted-by":"crossref","first-page":"525","DOI":"10.18632\/aging.202162","article-title":"Liraglutide Improved the Cognitive Function of Diabetic Mice via the Receptor of Advanced Glycation End Products Down\u2010Regulation","volume":"13","author":"Zhang H.","year":"2020","journal-title":"Aging (Albany NY)"},{"issue":"2","key":"e_1_2_22_232_1","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.apsb.2020.08.006","article-title":"Recent Developments on PET Radiotracers for TSPO and Their Applications in Neuroimaging","volume":"11","author":"Zhang L.","year":"2021","journal-title":"Acta Pharmaceutica Sinica B"},{"issue":"14","key":"e_1_2_22_233_1","doi-asserted-by":"crossref","first-page":"2478","DOI":"10.1016\/j.cell.2022.05.007","article-title":"An Inter\u2010Organ Neural Circuit for Appetite Suppression","volume":"185","author":"Zhang T.","year":"2022","journal-title":"Cell"},{"key":"e_1_2_22_234_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.117540","article-title":"Semaglutide Ameliorates Alzheimer's Disease and Restores Oxytocin in APP\/PS1 Mice and Human Brain Organoid Models","volume":"180","author":"Zhang Y.","year":"2024","journal-title":"Biomedicine & Pharmacotherapy"},{"key":"e_1_2_22_235_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.nantod.2022.101457","article-title":"Regulation of Neuroinflammation With GLP\u20101 Receptor Targeting Nanostructures to Alleviate Alzheimer's Symptoms in the Disease Models","volume":"44","author":"Zhao Y.","year":"2022","journal-title":"Nano Today"},{"issue":"5","key":"e_1_2_22_236_1","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1016\/j.neuron.2018.01.031","article-title":"TREM2 Is a Receptor for Beta\u2010Amyloid That Mediates Microglial Function","volume":"97","author":"Zhao Y.","year":"2018","journal-title":"Neuron"},{"key":"e_1_2_22_237_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2019.06.001","article-title":"The Protective Effects of Liraglutide on AD\u2010Like Neurodegeneration Induced by Oxidative Stress in Human Neuroblastoma SH\u2010SY5Y Cells","volume":"310","author":"Zheng C.","year":"2019","journal-title":"Chemico\u2010Biological Interactions"},{"issue":"1","key":"e_1_2_22_238_1","doi-asserted-by":"crossref","DOI":"10.1038\/s41392-024-01931-z","article-title":"Glucagon\u2010Like Peptide\u20101 Receptor: Mechanisms and Advances in Therapy","volume":"9","author":"Zheng Z.","year":"2024","journal-title":"Signal Transduction and Targeted Therapy"},{"issue":"1","key":"e_1_2_22_239_1","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.bbrc.2019.01.103","article-title":"Dulaglutide Ameliorates STZ Induced AD\u2010Like Impairment of Learning and Memory Ability by Modulating Hyperphosphorylation of Tau and NFs Through GSK3beta","volume":"511","author":"Zhou M.","year":"2019","journal-title":"Biochemical and Biophysical Research Communications"},{"issue":"2","key":"e_1_2_22_240_1","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.neuron.2008.01.003","article-title":"The Blood\u2010Brain Barrier in Health and Chronic Neurodegenerative Disorders","volume":"57","author":"Zlokovic B. V.","year":"2008","journal-title":"Neuron"}],"container-title":["European Journal of Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ejn.70718","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ejn.70718","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ejn.70718","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T11:00:53Z","timestamp":1792580453000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ejn.70718"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":239,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1111\/ejn.70718"],"URL":"https:\/\/doi.org\/10.1111\/ejn.70718","archive":["Portico"],"relation":{},"ISSN":["0953-816X","1460-9568"],"issn-type":[{"value":"0953-816X","type":"print"},{"value":"1460-9568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"2026-06-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70718"}}