{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T23:41:18Z","timestamp":1792712478620,"version":"4.5.0"},"reference-count":42,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T00:00:00Z","timestamp":1792627200000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J of Neuroscience"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Organization and specification of the nervous system start in the embryo and are largely controlled by a cluster of transcription factors known as HOX genes, which control body patterning and morphogenesis at the transcriptional level. However, this entire process requires the influence of multiple pathways, including cell signalling, genomic and post\u2010genomic pathways. These include the Wnt (wingless) pathway, which controls neuronal development and polarity, and the small miRNA pathway, which regulates genes post\u2010transcriptionally. In this study, we investigated\n                    <jats:italic>mir\u201057<\/jats:italic>\n                    , the homolog of human miR\u201010 in\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Caenorhabditis elegans<\/jats:italic>\n                    <\/jats:styled-content>\n                    and its role in influencing motor neuron function.\n                    <jats:italic>mir\u201057<\/jats:italic>\n                    is expressed posteriorly throughout development and enriched in motor neurons. Absence of\n                    <jats:italic>mir\u201057<\/jats:italic>\n                    results in decreased movement and abnormal axonal projections of posterior motor neurons. Moreover, the Wnt pathway genes\n                    <jats:italic>cam\u20101<\/jats:italic>\n                    and\n                    <jats:italic>mom\u20105<\/jats:italic>\n                    are\n                    <jats:italic>mir\u201057<\/jats:italic>\n                    targets and show elevated expression at the post\u2010transcriptional level in\n                    <jats:italic>mir\u201057<\/jats:italic>\n                    deletion mutants. Taken together this study suggests that\n                    <jats:italic>mir\u201057<\/jats:italic>\n                    influences Wnt receptor expression to maintain posterior motor neuron axon morphology.\n                  <\/jats:p>","DOI":"10.1111\/ejn.70736","type":"journal-article","created":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T23:36:08Z","timestamp":1792712168000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<i>mir\u201057<\/i>\n                    Influences Posterior Motor Neuron Axon Morphology in\n                    <i>Caenorhabditis elegans<\/i>"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-9373-6231","authenticated-orcid":false,"given":"Nethma","family":"Waduge","sequence":"first","affiliation":[{"name":"Department of Health Sciences and Biostatistics Swinburne University of Technology  Hawthorn Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah R.","family":"Tatnell","sequence":"additional","affiliation":[{"name":"Institute of Innovation, Science and Sustainability Federation University  Churchill Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9308-9790","authenticated-orcid":false,"given":"Gregory M.","family":"Davis","sequence":"additional","affiliation":[{"name":"Department of Health Sciences and Biostatistics Swinburne University of Technology  Hawthorn Australia"},{"name":"Institute of Innovation, Science and Sustainability Federation University  Churchill Victoria Australia"},{"name":"Department of Biochemistry and Molecular Biology, Development and Stem Cells Program Monash Biomedicine Discovery Institute  Clayton Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,22]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1155\/2024\/2408355"},{"key":"e_1_2_11_3_1","article-title":"Altered, miR\u201024a, miR\u2010124, and miR\u201021 Expression in Peripheral Blood Mononuclear Cells of Patients With Multiple Sclerosi","author":"Abolghasemi M.","year":"2022","journal-title":"Research Square"},{"key":"e_1_2_11_4_1","unstructured":"Altun Z. andD.Hall.2011. \u201cNervous System General Description Worm Atlas\u201d."},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crphar.2022.100133"},{"key":"e_1_2_11_6_1","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2024.1457704","article-title":"Upregulated b\u20105p as a Potential miRNA Signature in Amyotrophic Lateral Sclerosis Patients","volume":"18","author":"Dash B. 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