{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T21:15:40Z","timestamp":1791839740386,"version":"4.3.4"},"reference-count":41,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,10,25]],"date-time":"2012-10-25T00:00:00Z","timestamp":1351123200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Amyotrophic lateral sclerosis (<jats:styled-content style=\"fixed-case\">ALS<\/jats:styled-content>) is characterized by rapidly progressive paralysis of striated muscles due to the loss of upper and lower motor neurons. The disease leads to death within 2\u20135\u00a0years, mainly due to respiratory failure. The pathogenesis of <jats:styled-content style=\"fixed-case\">ALS<\/jats:styled-content> is still unexplained for the most part. In this study, we aimed to determine the prevalence of different cardiovascular, metabolic, and neuropsychiatric comorbidities in a large <jats:styled-content style=\"fixed-case\">ALS<\/jats:styled-content> cohort and to evaluate their influence on the disease course.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A cohort of 514 patients with <jats:styled-content style=\"fixed-case\">ALS<\/jats:styled-content> of our <jats:styled-content style=\"fixed-case\">ALS<\/jats:styled-content> outpatient clinic was investigated retrospectively with reference to known prognostic factors and comorbidities. The prevalence of concomitant diseases was compared with the data from the German general population. Uni\u2010 and multivariate survival analyses were performed using the <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>ox proportional hazards model and <jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>aplan\u2013<jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>eier analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The prevalence of cardiovascular diseases and cardiovascular risk factors was significantly lower in patients with <jats:styled-content style=\"fixed-case\">ALS<\/jats:styled-content> compared to the <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>erman general population, whilst the prevalence of dementia, parkinsonism, and depressive symptoms was significantly higher in the <jats:styled-content style=\"fixed-case\">ALS<\/jats:styled-content> cohort. None of the investigated comorbidities had an influence on the disease course or on the survival of patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Persons with cardiovascular diseases or risk factors seem to be at lower risk of <jats:styled-content style=\"fixed-case\">ALS<\/jats:styled-content>. Although these diseases are apparently somehow protective regarding <jats:styled-content style=\"fixed-case\">ALS<\/jats:styled-content> susceptibility, their presence did not modify disease progression and survival in patients with <jats:styled-content style=\"fixed-case\">ALS<\/jats:styled-content>. Our study further confirms the well\u2010known continuum between <jats:styled-content style=\"fixed-case\">ALS<\/jats:styled-content> and dementia. It also suggests a link with other neurodegenerative diseases such as Parkinson's disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.12015","type":"journal-article","created":{"date-parts":[[2012,10,25]],"date-time":"2012-10-25T05:36:10Z","timestamp":1351143370000},"page":"647-654","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":87,"title":["Prevalence and prognostic impact of comorbidities in amyotrophic lateral sclerosis"],"prefix":"10.1111","volume":"20","author":[{"given":"S.","family":"K\u00f6rner","sequence":"first","affiliation":[{"name":"Department of Neurology Hannover Medical School Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Kollewe","sequence":"additional","affiliation":[{"name":"Department of Neurology Hannover Medical School Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Ilsemann","sequence":"additional","affiliation":[{"name":"Department of Neurology Hannover Medical School Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"M\u00fcller\u2010Heine","sequence":"additional","affiliation":[{"name":"Department of Biometry Hannover Medical School Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Dengler","sequence":"additional","affiliation":[{"name":"Department of Neurology Hannover Medical School Hannover Germany"},{"name":"Center for Systems Neuroscience (ZSN) Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Krampfl","sequence":"additional","affiliation":[{"name":"Department of Neurology Hannover Medical School Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Petri","sequence":"additional","affiliation":[{"name":"Department of Neurology Hannover Medical School Hannover Germany"},{"name":"Center for Systems Neuroscience (ZSN) Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,10,25]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(10)70224-6"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000055861.95202.8D"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.3109\/17482960902822960"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2010.236752"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2011-301161"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000285080.70324.27"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-010-5805-z"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000297193.53986.6f"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181c1df1e"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12031-011-9609-0"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2012.02.059"},{"key":"e_1_2_7_13_1","first-page":"397","article-title":"Depression and quality of life in patients with amyotrophic lateral sclerosis","volume":"105","author":"Lule D","year":"2008","journal-title":"Dtsch Arztebl Int"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000167187.14501.0c"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2008.07.016"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0920-1211(95)00007-W"},{"key":"e_1_2_7_17_1","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1136\/jnnp.2006.104828","article-title":"Descriptive epidemiology of amyotrophic lateral sclerosis: new evidence and unsolved issues","volume":"79","author":"Logroscino G","year":"2008","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.21936"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.54.1.53"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-006-0226-8"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2007.118018"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1991.00530150051017"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.22114"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/74.3.328"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0017985"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2007.01.007"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1997.tb00251.x"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(76)92199-1"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1985.tb03215.x"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000172914.08967.dc"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(98)00203-2"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1121189X00001974"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurpsy.2011.06.003"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.3109\/17482968.2010.536839"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(10)70195-2"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1353-8020(11)70059-1"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1159\/000078505"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.23200"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22611"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aws004"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2004.03765.x"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21620"}],"container-title":["European Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fene.12015","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.12015","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T11:33:53Z","timestamp":1700652833000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ene.12015"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10,25]]},"references-count":41,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,4]]}},"alternative-id":["10.1111\/ene.12015"],"URL":"https:\/\/doi.org\/10.1111\/ene.12015","archive":["Portico"],"relation":{},"ISSN":["1351-5101","1468-1331"],"issn-type":[{"value":"1351-5101","type":"print"},{"value":"1468-1331","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,10,25]]},"assertion":[{"value":"2012-07-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-09-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-10-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}