{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T05:27:09Z","timestamp":1788413229922,"version":"build-2803163510"},"reference-count":44,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2012,11,4]],"date-time":"2012-11-04T00:00:00Z","timestamp":1351987200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>A significant proportion of cryptogenic ischaemic strokes are due to paroxysmal atrial fibrillation (<jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content>). As paroxysmal <jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content> appears to inexorably progress to persistent or permanent <jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content>, this study with long\u2010term follow\u2010up was designed to establish the profile of patients who developed <jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content> after hospital discharge.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All patients with cryptogenic ischaemic stroke over a 1\u2010year period were included (<jats:italic>n<\/jats:italic>\u00a0=\u00a0164). Patients were prospectively followed up at the outpatient clinic. Information on long\u2010term outcome included the presence of newly diagnosed <jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">NDAF<\/jats:styled-content>). A specific <jats:styled-content style=\"fixed-case\">NDAF<\/jats:styled-content> assessment was performed at least 2\u00a0years after the index stroke using a structured telephone interview. Baseline clinical, laboratory, and echocardiographic data of these patients were retrospectively recorded. Independent predictive factors were then used to produce a predictive grading score for <jats:styled-content style=\"fixed-case\">NDAF<\/jats:styled-content>, derived by logistic regression analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>With a median follow\u2010up of 854\u00a0days, 22 cases of <jats:styled-content style=\"fixed-case\">NDAF<\/jats:styled-content> (13%) were observed. On multivariate analysis, factors associated with <jats:styled-content style=\"fixed-case\">NDAF<\/jats:styled-content> were age \u226572\u00a0years (two points), history of coronary artery disease (one point) or stroke (one point), and left atrial area \u226516\u00a0cm<jats:sup>2<\/jats:sup> (two points) (total score ranging from 0 to 6). Patients with a score \u22641 point did not have <jats:styled-content style=\"fixed-case\">NDAF<\/jats:styled-content> during follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In cryptogenic ischaemic stroke, the <jats:styled-content style=\"fixed-case\">NDAF<\/jats:styled-content> score can be used to target patients at high risk of developing <jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content> after hospital discharge, as a score of 0\u20131 was highly predictive of the absence of <jats:styled-content style=\"fixed-case\">NDAF<\/jats:styled-content> during follow\u2010up. These results need to be confirmed in prospective studies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.12017","type":"journal-article","created":{"date-parts":[[2012,11,5]],"date-time":"2012-11-05T01:27:12Z","timestamp":1352078832000},"page":"1352-1359","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Predictors of newly diagnosed atrial fibrillation in cryptogenic stroke: a cohort study"],"prefix":"10.1111","volume":"20","author":[{"given":"J.\u2010M.","family":"Bugnicourt","sequence":"first","affiliation":[{"name":"Department of Neurology Amiens University Hospital Amiens France"},{"name":"Laboratory of Functional Neurosciences and Pathology (EA 4559) Amiens France"},{"name":"INSERM U1088 Amiens France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Flament","sequence":"additional","affiliation":[{"name":"Department of Neurology Amiens University Hospital Amiens 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