{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,19]],"date-time":"2026-04-19T07:28:30Z","timestamp":1776583710747,"version":"3.51.2"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,12,24]],"date-time":"2012-12-24T00:00:00Z","timestamp":1356307200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Somatosensory <jats:styled-content style=\"fixed-case\">t<\/jats:styled-content>emporal <jats:styled-content style=\"fixed-case\">d<\/jats:styled-content>iscrimination <jats:styled-content style=\"fixed-case\">t<\/jats:styled-content>hreshold (<jats:styled-content style=\"fixed-case\">STDT<\/jats:styled-content>) is defined as the threshold at which two tactile stimuli applied to the skin are perceived as clearly distinct.<\/jats:p><jats:p>The aim of the study was to investigate whether the extent of <jats:styled-content style=\"fixed-case\">STDT<\/jats:styled-content> alterations differs between patients with parkinsonian type <jats:styled-content style=\"fixed-case\">m<\/jats:styled-content>ultiple <jats:styled-content style=\"fixed-case\">s<\/jats:styled-content>ystem <jats:styled-content style=\"fixed-case\">a<\/jats:styled-content>trophy (<jats:styled-content style=\"fixed-case\">MSA<\/jats:styled-content>\u2010P) and patients with <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>arkinson's <jats:styled-content style=\"fixed-case\">d<\/jats:styled-content>isease (<jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>). Possible differences between the two groups may help to differentiate <jats:styled-content style=\"fixed-case\">MSA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">P<\/jats:styled-content> from <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>STDT was investigated in 20 patients with <jats:styled-content style=\"fixed-case\">MSA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>, 21 patients with <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> and 18 age\u2010matched healthy subjects. The clinical evaluation included the <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>ini\u2010<jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>ental <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>tate <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>xamination, <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>oehn and <jats:styled-content style=\"fixed-case\">Y<\/jats:styled-content>ahr <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>cale, <jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>rontal <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>ssessment <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>attery, <jats:styled-content style=\"fixed-case\">U<\/jats:styled-content>nified <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>ultiple <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>ystem <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>trophy <jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>ating <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>cale for patients with <jats:styled-content style=\"fixed-case\">MSA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>, and <jats:styled-content style=\"fixed-case\">U<\/jats:styled-content>nified <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>arkinson's <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>isease <jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>ating <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>cale for patients with <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>. <jats:styled-content style=\"fixed-case\">STDT<\/jats:styled-content> was investigated by delivering paired electrical stimuli starting with an inter\u2010stimulus interval (<jats:styled-content style=\"fixed-case\">ISI<\/jats:styled-content>) of 0\u2005ms (simultaneous pair), and progressively increasing the <jats:styled-content style=\"fixed-case\">ISI<\/jats:styled-content>s in 10\u2010ms steps.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Between\u2010group <jats:sc>anova<\/jats:sc> showed that <jats:styled-content style=\"fixed-case\">STDT<\/jats:styled-content> statistically differed in <jats:styled-content style=\"fixed-case\">MSA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">P<\/jats:styled-content> versus patients with <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> and healthy subjects. <jats:italic>Post hoc<\/jats:italic> showed that <jats:styled-content style=\"fixed-case\">STDT<\/jats:styled-content> values in patients with <jats:styled-content style=\"fixed-case\">MSA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">P<\/jats:styled-content> were significantly higher than those in patients with <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> and healthy subjects. <jats:styled-content style=\"fixed-case\">Receiver operating characteristic<\/jats:styled-content> curve analysis showed that <jats:styled-content style=\"fixed-case\">STDT<\/jats:styled-content> testing yielded high diagnostic specificity and sensitivity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>STDT is abnormal in patients with <jats:styled-content style=\"fixed-case\">MSA<\/jats:styled-content>\u2010P and <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>. The degree of <jats:styled-content style=\"fixed-case\">STDT<\/jats:styled-content> abnormalities is higher in patients with <jats:styled-content style=\"fixed-case\">MSA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">P<\/jats:styled-content> than in patients with <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.12059","type":"journal-article","created":{"date-parts":[[2012,12,24]],"date-time":"2012-12-24T06:46:45Z","timestamp":1356331605000},"page":"714-719","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Somatosensory temporal discrimination threshold may help to differentiate patients with multiple system atrophy from patients with <scp>P<\/scp>arkinson's disease"],"prefix":"10.1111","volume":"20","author":[{"given":"L.","family":"Rocchi","sequence":"first","affiliation":[{"name":"Department of Neurology and Psychiatry 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