{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T16:13:44Z","timestamp":1789229624368,"version":"build-2803163510"},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,1,7]],"date-time":"2013-01-07T00:00:00Z","timestamp":1357516800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>To evaluate the association between systolic, diastolic and pulse pressure, and increase in ventricular size (VS). Observations in laboratory animals suggest intraventricular pulse pressure (systolic\u2013diastolic) may play a role in ventricular enlargement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Initial magnetic resonance (<jats:styled-content style=\"fixed-case\">MR<\/jats:styled-content>) scans and vascular risk factors evaluation were performed in 1812 Atherosclerosis Risk in Communities participants in 1994\u20131995. In 2004\u20132006, 1130 participants underwent repeat <jats:styled-content style=\"fixed-case\">MR<\/jats:styled-content>. VS was rated using a validated nine\u2010point scale. Multiple logistic regression analysis assessed association between blood pressure measures and pulse pressure, and the change between the <jats:styled-content style=\"fixed-case\">MR<\/jats:styled-content> scans of VS controlling for age, sex and race.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At baseline 1112 participants (385 black women, 200 black men, 304 white women and 223 white men) had a mean age of 61.7\u2005\u00b1\u20054.3\u2005years. In adjusted models pulse pressure at baseline was associated with an increase in VS [odds ratio (OR) 1.19, 95% confidence interval (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>) 1.01\u20131.40], as was systolic pressure (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 1.28, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.03\u20131.58).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Systolic pressure and pulse pressure are associated with future development of increased VS. The findings are consistent with the animal literature that increased pulse pressure predisposes to risk of future increased VS. High pulse pressure might play a role in the pathogenesis of normal pressure hydrocephalus.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.12067","type":"journal-article","created":{"date-parts":[[2013,1,7]],"date-time":"2013-01-07T14:14:40Z","timestamp":1357568080000},"page":"720-724","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Do systolic <scp>BP<\/scp> and pulse pressure relate to ventricular enlargement?"],"prefix":"10.1111","volume":"20","author":[{"given":"N. R.","family":"Graff\u2010Radford","sequence":"first","affiliation":[{"name":"Department of Neurology Mayo Clinic Jacksonville FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. S.","family":"Knopman","sequence":"additional","affiliation":[{"name":"Department of Neurology Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. D.","family":"Penman","sequence":"additional","affiliation":[{"name":"Department of Medicine Medical Center University of Mississippi Jackson MS USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. H.","family":"Coker","sequence":"additional","affiliation":[{"name":"University of North Carolina Chapel Hill NC USA"},{"name":"Division of Public Health Sciences Wake Forest School of Medicine Winston\u2010Salem NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. H.","family":"Mosley","sequence":"additional","affiliation":[{"name":"Department of Medicine Medical Center University of Mississippi Jackson MS USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,1,7]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1962.19.5.0405"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1967.00470300056010"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01918814"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(86)90488-9"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.37.5.868"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.27.1.24"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01400556"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10143-004-0349-2"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1989.00520430038014"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31821d753f"},{"key":"e_1_2_6_12_1","first-page":"1625","article-title":"A method for using MR to evaluate the effects of cardiovascular disease on the brain: the cardiovascular health study","volume":"15","author":"Bryan RN","year":"1994","journal-title":"Am J Neuroradiol"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.202.1.8988189"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000368814"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/105.1.65"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1999.90.2.0221"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.3171\/2010.11.JNS10967"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2008.09.020"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A0739"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2011.02.043"},{"key":"e_1_2_6_21_1","volume-title":"Review of Medical Physiology","author":"Ganong M","year":"2005"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.56.12.1746"}],"container-title":["European Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fene.12067","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.12067","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T11:33:21Z","timestamp":1700652801000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ene.12067"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1,7]]},"references-count":21,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,4]]}},"alternative-id":["10.1111\/ene.12067"],"URL":"https:\/\/doi.org\/10.1111\/ene.12067","archive":["Portico"],"relation":{},"ISSN":["1351-5101","1468-1331"],"issn-type":[{"value":"1351-5101","type":"print"},{"value":"1468-1331","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,1,7]]},"assertion":[{"value":"2012-08-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-11-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-01-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}