{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T17:19:19Z","timestamp":1791220759968,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2013,1,7]],"date-time":"2013-01-07T00:00:00Z","timestamp":1357516800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Antibodies against gastrointestinal antigens may indicate altered microbiota and immune responses in the gut. Recent experimental data suggest a connection between gastrointestinal immune responses and <jats:styled-content style=\"fixed-case\">CNS<\/jats:styled-content> autoimmunity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Antibodies against gliadin, tissue transglutaminase (t<jats:styled-content style=\"fixed-case\">TG<\/jats:styled-content>), intrinsic factor (<jats:styled-content style=\"fixed-case\">IF<\/jats:styled-content>), parietal cells (<jats:styled-content style=\"fixed-case\">PC<\/jats:styled-content>) and <jats:italic><jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>accharomyces cerevisiae<\/jats:italic> (<jats:styled-content style=\"fixed-case\">ASCA<\/jats:styled-content>) were screened in the sera of 45 patients with <jats:styled-content style=\"fixed-case\">AQP<\/jats:styled-content>4\u2010seropositive neuromyelitis optica (<jats:styled-content style=\"fixed-case\">NMO<\/jats:styled-content>) and <jats:styled-content style=\"fixed-case\">NMO<\/jats:styled-content> spectrum diseases (<jats:styled-content style=\"fixed-case\">NMO<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">NMO<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>), 17 patients with <jats:styled-content style=\"fixed-case\">AQP<\/jats:styled-content>4\u2010seronegative <jats:styled-content style=\"fixed-case\">NMO<\/jats:styled-content>, 85 patients with clinically definite multiple sclerosis (<jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content>), and 48 healthy controls (<jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010seven percentages of patients with <jats:styled-content style=\"fixed-case\">AQP<\/jats:styled-content>4\u2010seropositive <jats:styled-content style=\"fixed-case\">NMO<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">NMO<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content> and 28% of patients with <jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content> had at least one particular antibody in contrast to 8% of <jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content> (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01, respectively). Antibodies were most common (46%) in <jats:styled-content style=\"fixed-case\">AQP<\/jats:styled-content>4\u2010seropositive myelitis (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.01 versus <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content>,<jats:italic> P<\/jats:italic>\u00a0=\u00a00.05 versus <jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content>). Anti\u2010gliadin and <jats:styled-content style=\"fixed-case\">ASCA<\/jats:styled-content> were more frequent in the <jats:styled-content style=\"fixed-case\">AQP<\/jats:styled-content>4\u2010seropositive <jats:styled-content style=\"fixed-case\">NMO<\/jats:styled-content>\u2010spectrum compared to controls (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.01 and <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Antibody responses against gastrointestinal antigens are common in <jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">AQP<\/jats:styled-content>4\u2010seropositive <jats:styled-content style=\"fixed-case\">NMO<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">NMO<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>, especially in longitudinally extensive myelitis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.12072","type":"journal-article","created":{"date-parts":[[2013,1,7]],"date-time":"2013-01-07T14:13:30Z","timestamp":1357568010000},"page":"1492-1495","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":56,"title":["Antibody response against gastrointestinal antigens in demyelinating diseases of the central nervous system"],"prefix":"10.1111","volume":"20","author":[{"given":"M.","family":"Banati","sequence":"first","affiliation":[{"name":"Department of Neurology University of Pecs Pecs Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Csecsei","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Pecs Pecs Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Koszegi","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Pecs Pecs Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. 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