{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:39:13Z","timestamp":1788871153784,"version":"build-2803163510"},"reference-count":31,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,2,11]],"date-time":"2013-02-11T00:00:00Z","timestamp":1360540800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006775","name":"GE Healthcare","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100006775","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100008723","name":"Finnish Medical Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100008723","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2013,7]]},"abstract":"\n Background and purpose<\/jats:title>\n \n This study determined the correlation between uptake of the amyloid positron emission tomography (\n PET<\/jats:styled-content>\n ) imaging agent [\n 18<\/jats:sup>\n F]flutemetamol and amyloid\u2010\u03b2 measured by immunohistochemical and histochemical staining in a frontal cortical biopsy.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Fifteen patients with possible normal pressure hydrocephalus (\n NPH<\/jats:styled-content>\n ) and previous brain biopsy obtained during intracranial pressure monitoring underwent [\n 18<\/jats:sup>\n F]flutemetamol\n PET<\/jats:styled-content>\n . Seven of these patients also underwent [\n 11<\/jats:sup>\n C]\n P<\/jats:styled-content>\n ittsburgh compound\n B<\/jats:styled-content>\n (\n P<\/jats:styled-content>\n i\n B<\/jats:styled-content>\n )\n PET<\/jats:styled-content>\n . [\n 18<\/jats:sup>\n F]Flutemetamol and [\n 11<\/jats:sup>\n C]\n P<\/jats:styled-content>\n i\n B<\/jats:styled-content>\n uptake was quantified using standardized uptake value ratio (\n SUVR<\/jats:styled-content>\n ) with the cerebellar cortex as a reference region. Tissue amyloid\u2010\u03b2 was evaluated using the monoclonal antibody 4\n G<\/jats:styled-content>\n 8,\n T<\/jats:styled-content>\n hioflavin\u2010\n S<\/jats:styled-content>\n and\n B<\/jats:styled-content>\n ielschowsky silver stain.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n [\n 18<\/jats:sup>\n F]Flutemetamol and [\n 11<\/jats:sup>\n C]\n P<\/jats:styled-content>\n i\n B SUVR<\/jats:styled-content>\n s correlated with biopsy specimen amyloid\u2010\u03b2 levels contralateral (\n r\u2005<\/jats:italic>\n =\u20050.86,\n P\u2005<\/jats:italic>\n <\u20050.0001;\n r\u2005<\/jats:italic>\n =\u20050.96,\n P\u2005<\/jats:italic>\n =\u20050.0008) and ipsilateral (\n r\u2005<\/jats:italic>\n =\u20050.82,\n P\u2005<\/jats:italic>\n =\u20050.0002;\n r\u2005<\/jats:italic>\n =\u20050.87,\n P\u2005<\/jats:italic>\n =\u20050.01) to the biopsy site. Association between cortical composite [\n 18<\/jats:sup>\n F]flutemetamol\n SUVR<\/jats:styled-content>\n s and [\n 11<\/jats:sup>\n C]\n PiB SUVR<\/jats:styled-content>\n s was highly significant (\n r\u2005<\/jats:italic>\n =\u20050.97,\n P\u2005<\/jats:italic>\n =\u20050.0003).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n [\n 18<\/jats:sup>\n F]Flutemetamol detects brain amyloid\u2010\u03b2\n in vivo<\/jats:italic>\n with moderate to high sensitivity and high specificity. This agent, therefore, represents a valuable new tool to study and verify the presence of amyloid\u2010\u03b2 pathology, both in patients with possible\n NPH<\/jats:styled-content>\n and among the wider population.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/ene.12102","type":"journal-article","created":{"date-parts":[[2013,2,11]],"date-time":"2013-02-11T07:39:06Z","timestamp":1360568346000},"page":"1043-1052","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Positron emission tomography with [\n 18<\/sup>\n F]flutemetamol and [\n 11<\/sup>\n C]\n PiB<\/scp>\n for\n in vivo<\/i>\n detection of cerebral cortical amyloid in normal pressure hydrocephalus patients"],"prefix":"10.1111","volume":"20","author":[{"given":"V.","family":"Leinonen","sequence":"first","affiliation":[{"name":"Department of Neurosurgery KUH NeuroCenter Kuopio University Hospital and Neurosurgery Institute of Clinical Medicine University of Eastern Finland Kuopio Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. O.","family":"Rinne","sequence":"additional","affiliation":[{"name":"Turku PET Centre University of Turku Turku University Hospital Turku Finland"},{"name":"Department of Neurology Turku University Hospital Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. A.","family":"Virtanen","sequence":"additional","affiliation":[{"name":"Turku PET Centre University of Turku Turku University Hospital Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Eskola","sequence":"additional","affiliation":[{"name":"Turku PET Centre University of Turku Turku University Hospital Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Rummukainen","sequence":"additional","affiliation":[{"name":"Department of Pathology Kuopio University Hospital Kuopio Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Huttunen","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery KUH NeuroCenter Kuopio University Hospital and Neurosurgery Institute of Clinical Medicine University of Eastern Finland Kuopio Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"von und zu Fraunberg","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery KUH NeuroCenter Kuopio University Hospital and Neurosurgery Institute of Clinical Medicine University of Eastern Finland Kuopio Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Nerg","sequence":"additional","affiliation":[{"name":"Department of Neurology KUH NeuroCenter Kuopio University Hospital Kuopio Finland"},{"name":"Unit of Neurology Institute of Clinical Medicine University of Eastern Finland Kuopio Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. M.","family":"Koivisto","sequence":"additional","affiliation":[{"name":"Department of Neurology KUH NeuroCenter Kuopio University Hospital Kuopio Finland"},{"name":"Unit of Neurology Institute of Clinical Medicine University of Eastern Finland Kuopio Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Rinne","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery KUH NeuroCenter Kuopio University Hospital and Neurosurgery Institute of Clinical Medicine University of Eastern Finland Kuopio Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. E.","family":"J\u00e4\u00e4skel\u00e4inen","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery KUH NeuroCenter Kuopio University Hospital and Neurosurgery Institute of Clinical Medicine University of Eastern Finland Kuopio Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Buckley","sequence":"additional","affiliation":[{"name":"Medical Diagnostics GE Healthcare Amersham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Smith","sequence":"additional","affiliation":[{"name":"Medical Diagnostics GE Healthcare Amersham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. 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