{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T04:07:14Z","timestamp":1790482034017,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,2,9]],"date-time":"2013-02-09T00:00:00Z","timestamp":1360368000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>The pathogenesis of multiple sclerosis (<jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content>) is still not fully understood, but multiple infections are known to be crucial in the development of the disease. Periodontitis caused by periodontopathic polymicrobial infections is among the most common chronic infectious disorders. This case\u2013control study aimed to investigate the association between chronic periodontitis (<jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content>) and <jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content> using a population\u2010based dataset in <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>aiwan.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study included 316 cases who had a diagnosis of <jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content> and 1580 randomly selected controls. We performed conditional logistic regressions to investigate the association between <jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content> and having been previously diagnosed with <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The results reveal that the prevalence of earlier <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content> was 25.6% and 15.4% for cases and controls, respectively (<jats:italic>P\u2005<\/jats:italic>&lt;\u20050.001). Conditional logistic regression analysis revealed that cases were 1.86 [95% confidence interval (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>)\u2005=\u20051.39\u20132.48] times as likely as controls to have been previously diagnosed with <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content>, after adjusting for sociodemographic characteristics as well as hyperlipidemia, hypertension, coronary heart disease, alcohol abuse\/alcohol\u2010dependence syndrome, tobacco use disorder and chronic obstructive pulmonary disease. After analyzing by gender, it was realized that while female cases had a higher chance than female controls of having earlier <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content> (adjusted odds ratio =\u20052.08; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\u2005=\u20051.49\u20132.95), there was no statistical association detected between these two conditions in men.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study provides evidence for an association between <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content> in female, but not male, subjects. Further epidemiological studies are needed to confirm the association and gender\u2010specific differences found in the present study.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.12103","type":"journal-article","created":{"date-parts":[[2013,2,9]],"date-time":"2013-02-09T06:17:23Z","timestamp":1360390643000},"page":"1053-1059","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":73,"title":["Association between multiple sclerosis and chronic periodontitis: a population\u2010based pilot study"],"prefix":"10.1111","volume":"20","author":[{"given":"J.\u2010J.","family":"Sheu","sequence":"first","affiliation":[{"name":"Department of Neurology Taipei Medical University Hospital Taipei Taiwan"},{"name":"Neuroscience Research Center Taipei Medical University Hospital Taipei Taiwan"},{"name":"Department of Neurology School of Medicine College of Medicine Taipei Medical University Taipei 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