{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:49:14Z","timestamp":1787014154898,"version":"build-2736575974"},"reference-count":6,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,2,11]],"date-time":"2013-02-11T00:00:00Z","timestamp":1360540800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2014,1]]},"abstract":"\n Background and purpose<\/jats:title>\n \n Acute severe exacerbations of myasthenia gravis (\n MG<\/jats:styled-content>\n ) are common in both early and late onset\n MG<\/jats:styled-content>\n . We wished to examine the current management in the intensive care unit (\n ICU<\/jats:styled-content>\n ) of severe exacerbations of\n MG<\/jats:styled-content>\n and to study the long\u2010term prognosis of\n MG<\/jats:styled-content>\n following discharge from the\n ICU<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n We retrospectively reviewed the medical records of all patients admitted to a specialist neuro\u2010\n ICU<\/jats:styled-content>\n with acute exacerbations of\n MG<\/jats:styled-content>\n over a 12\u2010year period.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n We identified 38 patients. Over 60% were over the age of 50\u00a0years, and\n MG<\/jats:styled-content>\n was newly diagnosed in over 40%. Intubation was required in 63%, and over 90% of patients were treated with prednisolone and\/or intravenous immunoglobulin. Four patients died in hospital. The remainder of patients were followed up for a mean of 4\u00a0years, and the majority were either asymptomatic or had mild symptoms of\n MG<\/jats:styled-content>\n at clinical review.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Despite the significant morbidity and mortality associated with severe exacerbations of\n MG<\/jats:styled-content>\n , specialized neurointensive care can result in a good long\u2010term prognosis in both early\u2010 and late\u2010onset\n MG<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/ene.12115","type":"journal-article","created":{"date-parts":[[2013,2,11]],"date-time":"2013-02-11T07:39:18Z","timestamp":1360568358000},"page":"171-173","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Myasthenia gravis \u2013 treatment of acute severe exacerbations in the intensive care unit results in a favourable long\u2010term prognosis"],"prefix":"10.1111","volume":"21","author":[{"given":"J.","family":"Spillane","sequence":"first","affiliation":[{"name":"UCL Institute of Neurology London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. P.","family":"Hirsch","sequence":"additional","affiliation":[{"name":"ICU National Hospital for Neurology and Neurosurgery London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. M.","family":"Kullmann","sequence":"additional","affiliation":[{"name":"UCL Institute of Neurology London UK"},{"name":"ICU National Hospital for Neurology and Neurosurgery London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Taylor","sequence":"additional","affiliation":[{"name":"ICU National Hospital for Neurology and Neurosurgery London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. S.","family":"Howard","sequence":"additional","affiliation":[{"name":"ICU National Hospital for Neurology and Neurosurgery London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,2,11]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.48.5.1253"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2007.04.045"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1981.tb33765.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181a41211"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-1331.1998.520137.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31821e5505"}],"container-title":["European Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fene.12115","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.12115","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T22:21:46Z","timestamp":1696285306000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ene.12115"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,2,11]]},"references-count":6,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,1]]}},"alternative-id":["10.1111\/ene.12115"],"URL":"https:\/\/doi.org\/10.1111\/ene.12115","archive":["Portico"],"relation":{},"ISSN":["1351-5101","1468-1331"],"issn-type":[{"value":"1351-5101","type":"print"},{"value":"1468-1331","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,2,11]]},"assertion":[{"value":"2012-11-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-01-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-02-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}