{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T04:27:00Z","timestamp":1791606420854,"version":"4.3.4"},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,3,21]],"date-time":"2013-03-21T00:00:00Z","timestamp":1363824000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Essential tremor (<jats:styled-content style=\"fixed-case\">ET<\/jats:styled-content>) is a chronic, progressive neurological disorder in which disease burden may slowly accrue. There are few long\u2010term studies, and the clinical and functional status of patients, with each decade of disease duration, has not been documented in detail. We used cross\u2010sectional data on 335 patients with <jats:styled-content style=\"fixed-case\">ET<\/jats:styled-content> (disease duration 1\u201381\u2005years) to produce clinical snapshots of the disease at each 10\u2010year milestone (i.e. &lt;\u200510, 10\u201319, 20\u201329, 30\u201339, \u2265\u200540\u2005years). We hope these data will be of value in clinical\u2010prognostic settings both to patients and their treating physicians.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this cross\u2010sectional, clinical\u2010epidemiological study at Columbia\u2010University Medical Center, each patient underwent a single evaluation, including self\u2010reported measures of tremor\u2010related disability, performance\u2010based measures of function, and neurologist\u2010assessments of tremor type, location and severity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A variety of metrics of tremor severity increased across the 10\u2010year time intervals. By \u2265\u200540\u2005years duration, one\u2010third of patients had tremor in at least two cranial locations (neck, voice, jaw), and the proportion with high\u2010amplitude tremor reached 20.3% (while drawing spirals), 33.8% (spilling while drinking) and 60.8% (spilling while using a spoon). Yet even in the longest tremor duration group, very few (&lt;\u200510%) were incapacitated (i.e. completely unable to perform the above\u2010mentioned tasks), and one\u2010third continued to exhibit no cranial tremor.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These data paint a picture of progressive decade\u2010by\u2010decade decline in <jats:styled-content style=\"fixed-case\">ET<\/jats:styled-content>. Yet patients with long disease duration did not relentlessly converge at the same end\u2010stage of severe, functionally incapacitating, diffuse tremor. In this respect, long\u2010duration <jats:styled-content style=\"fixed-case\">ET<\/jats:styled-content> patients presented a heterogeneous picture.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.12123","type":"journal-article","created":{"date-parts":[[2013,3,22]],"date-time":"2013-03-22T15:34:53Z","timestamp":1363966493000},"page":"949-954","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":60,"title":["Essential tremor 10, 20, 30, 40: clinical snapshots of the disease by decade of duration"],"prefix":"10.1111","volume":"20","author":[{"given":"E. D.","family":"Louis","sequence":"first","affiliation":[{"name":"G.H. Sergievsky Center College of Physicians and Surgeons Columbia University New York NY USA"},{"name":"Department of Neurology College of Physicians and Surgeons Columbia University New York NY USA"},{"name":"Taub Institute for Research on Alzheimer's Disease and the Aging Brain College of Physicians and Surgeons Columbia University New York NY USA"},{"name":"Department of Epidemiology Mailman School of Public Health Columbia University New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Gerbin","sequence":"additional","affiliation":[{"name":"G.H. Sergievsky Center College of Physicians and Surgeons Columbia University New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Galecki","sequence":"additional","affiliation":[{"name":"G.H. 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