{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T11:24:43Z","timestamp":1775129083794,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,4,3]],"date-time":"2013-04-03T00:00:00Z","timestamp":1364947200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Pre\u2010clinical studies indicate a potential detrimental effect of ethanol on tissue sparing and locomotor recovery in animal models of spinal cord injury (<jats:styled-content style=\"fixed-case\">SCI<\/jats:styled-content>). Given this, an examination of whether blood alcohol concentration (<jats:styled-content style=\"fixed-case\">BAC<\/jats:styled-content>) is a potential determinant of survival and neurological and functional recovery after acute traumatic <jats:styled-content style=\"fixed-case\">SCI<\/jats:styled-content> was carried out.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All patients who were enrolled in the Third National Spinal Cord Injury Study (<jats:styled-content style=\"fixed-case\">NASCIS<\/jats:styled-content>\u20103) were included. The study population was divided into \u2018non\u2010alcohol\u2019 (<jats:styled-content style=\"fixed-case\">BAC<\/jats:styled-content> equal to 0\u2030), \u2018legal\u2019 (<jats:styled-content style=\"fixed-case\">BAC<\/jats:styled-content> greater than 0 up to 0.8\u2030) and \u2018illegal\u2019 (<jats:styled-content style=\"fixed-case\">BAC<\/jats:styled-content> greater than 0.8\u2030) subgroups. Outcome measures included survival, <jats:styled-content style=\"fixed-case\">NASCIS<\/jats:styled-content> motor and sensory scores, <jats:styled-content style=\"fixed-case\">NASCIS<\/jats:styled-content> pain scores and Functional Independence Measure (<jats:styled-content style=\"fixed-case\">FIM<\/jats:styled-content>) determinants at baseline and at 6\u00a0weeks, 6\u00a0months and 1\u00a0year post\u2010<jats:styled-content style=\"fixed-case\">SCI<\/jats:styled-content>. Analyses were adjusted for major potential confounders: age, sex, ethnicity, trial protocol, Glasgow coma score, and cause, level and severity of <jats:styled-content style=\"fixed-case\">SCI<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 499 patients (423 males and 76 females; ages from 14 to 92\u00a0years), the mean <jats:styled-content style=\"fixed-case\">BAC<\/jats:styled-content> was 0.054\u00a0\u00b1\u00a00.006\u2030 (range 0\u20131). The survival at 1\u00a0year (94.4%) was not associated with the <jats:styled-content style=\"fixed-case\">BAC<\/jats:styled-content> (<jats:italic>P\u00a0<\/jats:italic>=\u00a00.374). Moreover, <jats:styled-content style=\"fixed-case\">BAC<\/jats:styled-content> was not significantly correlated with motor recovery (<jats:italic>P\u00a0<\/jats:italic>&gt;\u00a00.166), sensory recovery (<jats:italic>P\u00a0<\/jats:italic>&gt;\u00a00.323), change in pain score (<jats:italic>P\u00a0<\/jats:italic>&gt;\u00a00.312) or functional recovery (<jats:italic>P\u00a0<\/jats:italic>&gt;\u00a00.133) at 6\u00a0weeks, 6\u00a0months and 1\u00a0year post\u2010<jats:styled-content style=\"fixed-case\">SCI<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results, for the first time, show that the <jats:styled-content style=\"fixed-case\">BAC<\/jats:styled-content> at emergency admission does not adversely affect the patients' mortality, neurological impairment or functional disability over the course of the first year after <jats:styled-content style=\"fixed-case\">SCI<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.12145","type":"journal-article","created":{"date-parts":[[2013,4,3]],"date-time":"2013-04-03T06:18:41Z","timestamp":1364969921000},"page":"1101-1106","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Blood alcohol concentration as a determinant of outcomes after traumatic spinal cord injury"],"prefix":"10.1111","volume":"20","author":[{"given":"J. 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