{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T20:41:21Z","timestamp":1765485681996,"version":"3.37.3"},"reference-count":40,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2013,4,14]],"date-time":"2013-04-14T00:00:00Z","timestamp":1365897600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000890","name":"National Multiple Sclerosis Society","doi-asserted-by":"crossref","award":["RG3743"],"award-info":[{"award-number":["RG3743"]}],"id":[{"id":"10.13039\/100000890","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Pediatric MS Center of Excellence Center"},{"name":"Department of Defense Multiple Sclerosis Program","award":["MS090122"],"award-info":[{"award-number":["MS090122"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>To evaluate the associations between retinal nerve fiber layer (<jats:styled-content style=\"fixed-case\">RNFL<\/jats:styled-content>) thickness and lipid profiles in multiple sclerosis (<jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study enrolled 136 patients with <jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content> (<jats:italic>n\u2005<\/jats:italic>=\u2005272 eyes; 108 females, 28 males, mean age: 46.7\u2005\u00b1\u20058.9\u2005years); 45% had a history of optic neuritis (ON). Subjects received optical coherence tomography (<jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content>) testing to assess <jats:styled-content style=\"fixed-case\">RNFL<\/jats:styled-content> thickness and visual acuity testing with <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>nellen charts. A subset of 88 patients received pattern reversal visual\u2010evoked potential (<jats:styled-content style=\"fixed-case\">PRVEP<\/jats:styled-content>) testing. Lipid profiles consisting of serum high\u2010density lipoprotein (<jats:styled-content style=\"fixed-case\">HDL<\/jats:styled-content>) cholesterol, low\u2010density lipoprotein (<jats:styled-content style=\"fixed-case\">LDL<\/jats:styled-content>) cholesterol and total cholesterol (TC) levels were obtained within \u00b1\u20056\u2005months of <jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content>. Regression analyses were used to assess the associations between <jats:styled-content style=\"fixed-case\">RNFL<\/jats:styled-content> thickness and lipid profile variables.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Low <jats:styled-content style=\"fixed-case\">RNFL<\/jats:styled-content> thickness (<jats:italic>P\u2005<\/jats:italic>=\u20050.008) and higher <jats:styled-content style=\"fixed-case\">PRVEP<\/jats:styled-content> latency (<jats:italic>P\u2005<\/jats:italic>=\u20050.017) were associated with high <jats:styled-content style=\"fixed-case\">LDL<\/jats:styled-content> cholesterol &gt;\u2005100\u2005mg\/dl status. Low <jats:styled-content style=\"fixed-case\">RNFL<\/jats:styled-content> thickness (<jats:italic>P\u2005<\/jats:italic>=\u20050.008) and higher <jats:styled-content style=\"fixed-case\">PRVEP<\/jats:styled-content> latency (<jats:italic>P\u2005<\/jats:italic>=\u20050.043) were associated with high <jats:styled-content style=\"fixed-case\">HDL<\/jats:styled-content> cholesterol levels. Low <jats:styled-content style=\"fixed-case\">RNFL<\/jats:styled-content> thickness was also associated with <jats:styled-content style=\"fixed-case\">HDL<\/jats:styled-content> cholesterol &gt;\u200560\u2005mg\/dl status (<jats:italic>P\u2005<\/jats:italic>=\u20050.001) and with TC &gt;\u2005200\u2005mg\/dl status (<jats:italic>P\u2005<\/jats:italic>=\u20050.015). The probability of average <jats:styled-content style=\"fixed-case\">RNFL<\/jats:styled-content> thickness in the lowest tertile (\u2264\u200533rd percentile) was associated with interactions between TC &gt;\u2005200\u2005mg\/dl status (<jats:italic>P\u2005<\/jats:italic>=\u20050.001, odds ratio\u2005=\u20057.5, 95% confidence interval\u2005=\u20052.7\u201321) with affected\/unaffected by ON status.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>High cholesterol adversely affects <jats:styled-content style=\"fixed-case\">RNFL<\/jats:styled-content> thickness in patients with <jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content> with ON.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.12162","type":"journal-article","created":{"date-parts":[[2013,4,14]],"date-time":"2013-04-14T15:58:42Z","timestamp":1365955122000},"page":"1264-1271","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Cholesterol affects retinal nerve fiber layer thickness in patients with multiple sclerosis with optic neuritis"],"prefix":"10.1111","volume":"20","author":[{"given":"A.","family":"Kardys","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Sciences State University of New York Buffalo NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Weinstock\u2010Guttman","sequence":"additional","affiliation":[{"name":"Department of Neurology State University of New York Buffalo NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Dillon","sequence":"additional","affiliation":[{"name":"Department of Neurology State University of New York Buffalo NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. 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