{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T02:36:30Z","timestamp":1789526190633,"version":"build-2803163510"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,4,22]],"date-time":"2013-04-22T00:00:00Z","timestamp":1366588800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Although Parkinson's disease (PD) is characterized by typical motor manifestations, non\u2010motor symptoms (NMS) are an outstanding part of the disease. At present, several specific instruments for assessment of NMS are available. The objective of our study was to determine the performance of the Movement Disorder Society\u2010Unified Parkinson's Disease Rating Scale (MDS\u2010UPDRS): Part I \u2013 Non\u2010Motor Aspects of Experiences of Daily Living (nM\u2010EDL) compared with the Non\u2010Motor Symptoms Scale (NMSS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>To this purpose, 434 consecutive patients with <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> were included in an international, observational, cross\u2010sectional study. The association between scores of both scales was determined by the Spearman rank correlation coefficient. Equations for transformation of total score of a scale to the other were constructed from weighted regression models and both, transformed and observed score, contrasted by means of the Lin's Concordance Correlation Coefficient (<jats:styled-content style=\"fixed-case\">LCCC<\/jats:styled-content>) and Bland\u2013Altman plot.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>As a whole, the prevalence of the NMS according to each scale was quite similar, and most of the correlations between their corresponding components were high (<jats:italic>r<\/jats:italic><jats:sub>S\u2005<\/jats:sub>&gt;\u20050.60). The total score correlation of the MDS\u2010UPDRS Part I with the NMSS was high (<jats:italic>r<\/jats:italic><jats:sub>S\u2005<\/jats:sub>=\u20050.81). Concerning the transformed scores, estimated scores only partially approach the observed ones (sharing about 60\u201364% of the variance) because residual variance increased with increasing magnitudes of the scores, i.e. the most severe patients (Bland\u2013Altman plot; LCCC\u2005&lt;\u20050.60 for severe patients).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>(i) MDS\u2010UPDRS Part I (<jats:styled-content style=\"fixed-case\">nM<\/jats:styled-content>\u2010EDL) and NMSS showed a strong convergent validity; (ii) however, transformed scores using the equations from weighted regression models showed that for patients with the most severe NMS they are not concordant.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.12165","type":"journal-article","created":{"date-parts":[[2013,4,22]],"date-time":"2013-04-22T13:29:42Z","timestamp":1366637382000},"page":"37-43","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":94,"title":["Assessing the non\u2010motor symptoms of Parkinson's disease: <scp>MDS<\/scp>\u2010<scp>UPDRS<\/scp> and <scp>NMS<\/scp> Scale"],"prefix":"10.1111","volume":"22","author":[{"given":"P.","family":"Martinez\u2010Martin","sequence":"first","affiliation":[{"name":"Alzheimer Center Reina Sofia Foundation and CIBERNED Carlos III Institute of Health Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. R.","family":"Chaudhuri","sequence":"additional","affiliation":[{"name":"National Parkinson Foundation Centre of Excellence Kings College Hospital and Kings College (Denmark Hill Campus) and University Hospital Lewisham London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. M.","family":"Rojo\u2010Abuin","sequence":"additional","affiliation":[{"name":"Department of Statistics Center of Human and Social Sciences, Spanish Council for Scientific Research Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Rodriguez\u2010Blazquez","sequence":"additional","affiliation":[{"name":"National Center of Epidemiology and CIBERNED Carlos III Institute of Health Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Alvarez\u2010Sanchez","sequence":"additional","affiliation":[{"name":"Department of Movement Disorders and Neurodegeneration CIREN La Habana Cuba"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Arakaki","sequence":"additional","affiliation":[{"name":"Department of Neurology Hospital Ramos Mejia Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Bergareche\u2010Yarza","sequence":"additional","affiliation":[{"name":"Department of Neurology Donostia Hospital, Biodonostia Institute and CIBERNED Sen Sebastian Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Chade","sequence":"additional","affiliation":[{"name":"Movement Disorders Unit Institute of Neurosciences Favaloro University INECO Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Garretto","sequence":"additional","affiliation":[{"name":"Department of Neurology Hospital Ramos Mejia Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Gershanik","sequence":"additional","affiliation":[{"name":"Movement Disorders Unit Institute of Neurosciences Favaloro University INECO Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. M.","family":"Kurtis","sequence":"additional","affiliation":[{"name":"Movement Disorders Program Department of Neurology Hospital Ruber Internacional Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. C.","family":"Martinez\u2010Castrillo","sequence":"additional","affiliation":[{"name":"Movement Disorders Unit Department of Neurology Hospital Ramon y Cajal IRYCIS Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Mendoza\u2010Rodriguez","sequence":"additional","affiliation":[{"name":"Department of Neurology Complejo Asistencial de Segovia Segovia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. P.","family":"Moore","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Miami Miami FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Rodriguez\u2010Violante","sequence":"additional","affiliation":[{"name":"Movement Disorders Unit Instituto Nacional de Neurologia y Neurocirugia Mexico DF Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Singer","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Miami Miami FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. 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