{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,26]],"date-time":"2026-04-26T09:22:02Z","timestamp":1777195322074,"version":"3.51.4"},"reference-count":43,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2013,5,17]],"date-time":"2013-05-17T00:00:00Z","timestamp":1368748800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"a Health and Labour Sciences Research"},{"name":"Ministry of Health, Labour and Welfare of Japan"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2013,9]]},"abstract":"Background and purpose<\/jats:title>The differences in the characteristics of thymus histology, coexisting autoimmune diseases and related autoantibodies between anti\u2010muscle\u2010specific receptor tyrosine kinase (M<\/jats:styled-content>uSK<\/jats:styled-content>)\u2010antibody (A<\/jats:styled-content>b)\u2010positive myasthenia gravis (MG<\/jats:styled-content>) patients, and anti\u2010acetylcholine receptor (AC<\/jats:styled-content>hR<\/jats:styled-content>)\u2010A<\/jats:styled-content>b\u2010positive MG<\/jats:styled-content> patients are not clearly defined.<\/jats:p><\/jats:sec>Methods<\/jats:title>The types of thymus histology, coexisting autoimmune diseases and associated Abs in 83 M<\/jats:styled-content>uSK<\/jats:styled-content>\u2010A<\/jats:styled-content>b\u2010positive patients nationwide were investigated and were compared with those in AC<\/jats:styled-content>hR<\/jats:styled-content>\u2010A<\/jats:styled-content>b\u2010positive patients followed at our institute (n<\/jats:italic>\u00a0=\u00a083). As for the autoantibodies associated with thymoma, titin Abs were measured.<\/jats:p><\/jats:sec>Results<\/jats:title>Thymoma was not present in any of the M<\/jats:styled-content>uSK<\/jats:styled-content>\u2010A<\/jats:styled-content>b\u2010positive patients but presented in 21 patients (25.3%) amongst the AC<\/jats:styled-content>hR<\/jats:styled-content>\u2010A<\/jats:styled-content>b\u2010positive patients. Titin Abs were absent in M<\/jats:styled-content>uSK<\/jats:styled-content>\u2010A<\/jats:styled-content>b\u2010positive patients but positive in 25 (30.1%) of the AC<\/jats:styled-content>hR<\/jats:styled-content>\u2010A<\/jats:styled-content>b\u2010positive patients. Concomitant autoimmune diseases were present in eight M<\/jats:styled-content>uSK<\/jats:styled-content>\u2010A<\/jats:styled-content>b\u2010positive patients (9.6%) amongst whom H<\/jats:styled-content>ashimoto's thyroiditis and rheumatoid arthritis predominated, whereas 22 AC<\/jats:styled-content>hR<\/jats:styled-content>\u2010A<\/jats:styled-content>b\u2010positive patients (26.5%) had one or more concomitant autoimmune diseases of which G<\/jats:styled-content>raves' disease predominated.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Differences in frequency of thymoma and thymic hyperplasia, coexisting autoimmune diseases and autoantibody positivity between M<\/jats:styled-content>uSK<\/jats:styled-content>\u2010A<\/jats:styled-content>b\u2010positive and AC<\/jats:styled-content>hR<\/jats:styled-content>\u2010A<\/jats:styled-content>b\u2010positive MG<\/jats:styled-content> were indicated, suggesting that, in contrast with AC<\/jats:styled-content>hR<\/jats:styled-content>\u2010A<\/jats:styled-content>b\u2010positive MG<\/jats:styled-content>, thymus does not seem to be involved in the pathogenic mechanisms of M<\/jats:styled-content>uSK<\/jats:styled-content>\u2010A<\/jats:styled-content>b\u2010positive MG<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.12169","type":"journal-article","created":{"date-parts":[[2013,5,17]],"date-time":"2013-05-17T06:41:16Z","timestamp":1368772876000},"page":"1272-1276","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Thymus histology and concomitant autoimmune diseases in J<\/scp>apanese patients with muscle\u2010specific receptor tyrosine kinase\u2010antibody\u2010positive myasthenia gravis"],"prefix":"10.1111","volume":"20","author":[{"given":"R.","family":"Nakata","sequence":"first","affiliation":[{"name":"Department of Clinical Neuroscience and Neurology Graduate School of 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