{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T21:16:41Z","timestamp":1790111801193,"version":"4.0.1"},"reference-count":23,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2013,5,5]],"date-time":"2013-05-05T00:00:00Z","timestamp":1367712000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2013,9]]},"abstract":"\n Background and purpose<\/jats:title>\n \n An association between high blood pressure (\n BP<\/jats:styled-content>\n ) in acute intracerebral hemorrhage (\n ICH<\/jats:styled-content>\n ) and hematoma growth (\n HG<\/jats:styled-content>\n ) has not been clearly demonstrated. Therefore, the impact of\n BP<\/jats:styled-content>\n changes and course on\n HG<\/jats:styled-content>\n and clinical outcome in patients with acute\n ICH<\/jats:styled-content>\n was determined.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n In total, 117 consecutive patients with acute (<6\u00a0h) supratentorial\n ICH<\/jats:styled-content>\n underwent baseline and 24\u2010h\n CT<\/jats:styled-content>\n scans,\n CT<\/jats:styled-content>\n angiography for the detection of the spot sign and non\u2010invasive\n BP<\/jats:styled-content>\n monitoring at 15\u2010min intervals over the first 24\u00a0h. Maximum and minimum\n BP<\/jats:styled-content>\n , maximum\n BP<\/jats:styled-content>\n increase and drop from baseline, and\n BP<\/jats:styled-content>\n variability values from systolic\n BP<\/jats:styled-content>\n (\n SBP<\/jats:styled-content>\n ), diastolic\n BP<\/jats:styled-content>\n and mean arterial pressure (\n MAP<\/jats:styled-content>\n ) were calculated.\n SBP<\/jats:styled-content>\n and\n MAP<\/jats:styled-content>\n loads were defined as the proportion of readings >180 and >130\u00a0mmHg, respectively.\n HG<\/jats:styled-content>\n (>33% or >6\u00a0ml), early neurological deterioration (\n END<\/jats:styled-content>\n ) and 3\u2010month mortality were recorded.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Baseline\n BP<\/jats:styled-content>\n variables were unrelated to either\n HG<\/jats:styled-content>\n or clinical outcome. Conversely,\n SBP<\/jats:styled-content>\n 180\u2010load independently predicted\n HG<\/jats:styled-content>\n (odds ratio 1.05, 95%\n CI<\/jats:styled-content>\n 1.010\u20131.097,\n P\u00a0<\/jats:italic>\n =\n \u00a0<\/jats:italic>\n 0.016), whilst both\n SBP<\/jats:styled-content>\n 180\u2010load (odds ratio 1.04, 95%\n CI<\/jats:styled-content>\n 1.001\u20131.076,\n P\u00a0<\/jats:italic>\n =\n \u00a0<\/jats:italic>\n 0.042) and\n SBP<\/jats:styled-content>\n variability (odds ratio 1.2, 95%\n CI<\/jats:styled-content>\n 1.047\u20131.380,\n P\u00a0<\/jats:italic>\n =\n \u00a0<\/jats:italic>\n 0.009) independently predicted\n END<\/jats:styled-content>\n . Although none of the\n BP<\/jats:styled-content>\n monitoring variables was associated with\n HG<\/jats:styled-content>\n in the spot\u2010sign\u2010positive group, higher maximum\n BP<\/jats:styled-content>\n increases from baseline and higher\n SBP<\/jats:styled-content>\n and\n MAP<\/jats:styled-content>\n loads were significantly related to\n HG<\/jats:styled-content>\n in the spot\u2010sign\u2010negative group.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n In patients with acute supratentorial\n ICH<\/jats:styled-content>\n ,\n SBP<\/jats:styled-content>\n 180\u2010load independently predicts\n HG<\/jats:styled-content>\n , whilst both\n SBP<\/jats:styled-content>\n 180\u2010load and\n SBP<\/jats:styled-content>\n variability predict\n END<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/ene.12180","type":"journal-article","created":{"date-parts":[[2013,5,5]],"date-time":"2013-05-05T05:42:40Z","timestamp":1367732560000},"page":"1277-1283","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":162,"title":["Impact of blood pressure changes and course on hematoma growth in acute intracerebral hemorrhage"],"prefix":"10.1111","volume":"20","author":[{"given":"D.","family":"Rodriguez\u2010Luna","sequence":"first","affiliation":[{"name":"Stroke Unit Department of Neurology Vall d'Hebron University Hospital Vall d'Hebron Research Institute Departament de Medicina Universitat Autonoma de Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Pi\u00f1eiro","sequence":"additional","affiliation":[{"name":"Stroke Unit Department of Neurology Vall d'Hebron University Hospital Vall d'Hebron Research Institute Departament de Medicina Universitat 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